Enhancing tissue penetration of certain antimicrobial agents with dimethyl sulfoxide
Abstract
Abstract A METHOD OF ENCHANCING TISSUE PENETRATION OF ANTIMICROBIAL AGENTS SELECTED FROM THE GROUP CONSISTING OF SULFONAMIDES, PENICILLINS, ANTIVIRAL AGENTS AND ANTIBIOTICS PRODUCED BY SPECIES OF STREPTOMYCERS BY CONJOINTLY APPLYING THE AGENT TO THE TISSUE WITH DIMETHYL SULFOXIDE. PENETRATION OF THE SKIN AND THE MUCOUS MEMBRANES OF THE BODY CAVITIES BY THESE AGENTS MAY BE ENCHANCED BY CONJOINT APPLICATION OF SUCH AGENTS AND DIMETHYL SULFOXIDE (DMSO) DIRECTLY TO SUCH MEMBRANES. PREFERABLY, FOR PENETRATION OF AGENTS THROUGH THE SKIN COMPOSITIONS OF DMSO AT CONCENTRATIONS OF 50% AND ABOVE ARE EMPLOYED AND FOR PENETRATION THROUGH MUSCOUS MEMBRANES COMPOSITIONS INCLUDING DMSO AT CONCENTRATIONS OF 10% AND ABOVE ARE EMPLOYED.
Inventors
- 👤 R Herschler
Bibliographic Details
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