US4296104A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutic dimethyl sulfoxide composition and methods of use
Assignee: Individual
•
Filing: 1979-08-30
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Granted: 1981-10-20
•
Expires: 1999-08-30
Abstract
Abstract The use of urea and/or ethanol with pharmaceutical compositions containing DMSO is disclosed. The result is a reduction in the undesirable side-effects normally associated with the application of DMSO compositions, enhancement of the desired physiological effects produced by DMSO compositions, and other benefits. Specific compositions contain DMSO with urea and/or alcohol and may also contain NaCl, KCl and/or acetamide. The use of DMSO to reduce the mortality rate of fish treated by hyperosmotic delivery is also disclosed.
Inventors
- 👤 Robert J. Herschler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:46
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/46; A61K31/00; A61K31/095; A61K31/10; A61K31/16; A61K31/17; A61K33/00; A61K33/14; A61K8/40; A61K8/42; A61P; A61P29/00; A61Q; A61Q19/00; A61Q3/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
69 words
In a method for administrating dimethyl sulfoxide to a host, the improvement comprising reducing the side effects of malodorous breath and skin reactions normally associated with such dimethyl sulfoxide administration, comprising the step of: administrating to said host a composition comprising dimethyl sulfoxide and a side-effect reducing agent taken from the group consisting of urea, or ethanol or mixtures thereof in an amount which is effective for said purpose.
Claim 2
Dependent Claim
69 words
In a method for administrating dimethyl sulfoxide to a host, the improvement comprising reducing the side effects of malodorous breath and skin reactions normally associated with such dimethyl sulfoxide administration, comprising the step of: administrating to said host a composition comprising dimethyl sulfoxide and a side-effect reducing agent taken from the group consisting of urea, or ethanol or mixtures thereof in an amount which is effective for said purpose.
Claim 3
Dependent Claim
12 words
A method according to claim 1 wherein said composition further includes acetamide.
Claim 4
Dependent Claim
13 words
The method according to claim 1 wherein said composition further includes sodium chloride.
Claim 5
Dependent Claim
13 words
The method according to claim 1 wherein said composition further includes potassium chloride.
Claim 6
Dependent Claim
12 words
The method according to claim 1 wherein said composition further includes water.
Claim 7
Dependent Claim
19 words
The method according to claim 1 wherein the weight ratio of urea to dimethyl sulfoxide is greater than 1:99.
Claim 8
Dependent Claim
18 words
The method according to claim 1 wherein the ratio of urea to dimethyl sulfoxide is greater than 1:9.
Claim 9
Dependent Claim
48 words
The method according to claim 1 wherein said composition has the following formulation: ______________________________________
dimethyl sulfoxide
about 19 grams;
urea about 9 grams;
sodium chloride about 1 gram; and
water at least about 6 grams;
______________________________________ whereby the aforementioned composition formulation is provided with the weight ratios noted.
References Cited (Backward Citations)
US4177267A
Cited
US3499961A
Cited
US3549770A
Cited
US3334012A
Cited
US3549771A
Cited
US3558434A
Cited
US3361555A
Cited
US3740420A
Cited
US3551554A
Cited
US3711606A
Cited
US3711602A
Cited
US3743727A
Cited
US4112946A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-19 | 1985-04-20 | 1985-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-19 | 1989-04-20 | 1989-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-19 | 1993-04-20 | 1993-10-20 | $7700.00 | Window Closed / Lapsed |