US4279913A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines
Assignee: Merck and Co Inc
•
Filing: 1979-01-29
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Granted: 1981-07-21
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Expires: 1999-01-29
Abstract
Abstract Novel substituted (3-loweralkylamino-2-R1O-propoxy)pyridines, their pharmaceutically acceptable salts, certain intermediates and their preparation are disclosed. These pyridines have pharmaceutically useful properties such as beta -adrenergic blocking activity.
Inventors
- 👤 John J. Baldwin
- 👤 Gerald S. Ponticello
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 08:51
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/73; C07D213/61; C07D213/62; C07D213/63; C07D213/64; C07D213/78; C07D213/79; C07D213/80; C07D213/84; C07D213/85; C07D217/00; C07D217/22; C07D217/24; C07D217/26; C07D221/00; C07D221/02; C07D221/04
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
72 words
A compound having the formula ##STR99##l wherein n' is 3 or 4, R is C 3 -C 4 branched alkyl, R 1 is H or ##STR100## wherein L is selected from C 1 -C 10 alkyl, phenyl and substituted phenyl having up to two substituents which are independently selected from C 1 -C 4 alkyl, C 1 -C 4 alkoxy and halo, and R 2 is CN, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
72 words
A compound having the formula ##STR99##l wherein n' is 3 or 4, R is C 3 -C 4 branched alkyl, R 1 is H or ##STR100## wherein L is selected from C 1 -C 10 alkyl, phenyl and substituted phenyl having up to two substituents which are independently selected from C 1 -C 4 alkyl, C 1 -C 4 alkoxy and halo, and R 2 is CN, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
8 words
Compound of claim 1 having the S-isomer configuration.
Claim 4
Dependent Claim
9 words
Compound of claim 1 wherein R 1 is H.
Claim 5
Dependent Claim
16 words
A compound of claim 1 wherein R 1 is H and R is isopropyl or t-butyl.
Claim 6
Dependent Claim
9 words
A compound of claim 4 wherein n' is 3.
Claim 7
Dependent Claim
9 words
A compound of claim 4 wherein n' is 4.
Claim 8
Dependent Claim
9 words
A compound of claim 1 having the formula ##STR101##
Claim 9
Dependent Claim
20 words
A pharmaceutical composition for effecting β-adrenergic blockade containing an effective amount of a compound of claim 1 and a diluent.
Claim 10
Dependent Claim
19 words
A pharmaceutical composition for treating hypertension containing an effective amount of a compound of claim 1 and a diluent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-07-20 | 1985-01-19 | 1985-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-07-20 | 1989-01-19 | 1989-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-07-20 | 1993-01-19 | 1993-07-21 | $7700.00 | Window Closed / Lapsed |