US4060601A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines
Assignee: Merck and Co Inc
•
Filing: 1976-06-15
•
Granted: 1977-11-29
•
Expires: 1996-06-15
Abstract
Abstract Novel substituted (3-loweralkylamino-2-R 1 O-propoxy)pyridines, their pharmaceutically acceptable salts and their preparation are disclosed. These pyridines have pharmaceutical properties such as anti-hypertensive activity of rapid onset.
Inventors
- 👤 John J. Baldwin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 01:22
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/62; C07D213/63; C07D213/64; A; A61; A61P; A61P9/00; A61P9/08; A61P9/12; C07D213/61; C07D213/70; C07D213/71
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
26 words
Compound having the formula ##STR15## wherein R is C 3 -C 4 branched alkyl and R 2 is selected from trihalomethyl, ##STR16## pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
26 words
Compound having the formula ##STR15## wherein R is C 3 -C 4 branched alkyl and R 2 is selected from trihalomethyl, ##STR16## pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
9 words
Compound of claim 1 wherein R is tert. butyl.
Claim 4
Dependent Claim
8 words
Compound of claim 1 having the formula ##STR17##
Claim 5
Dependent Claim
11 words
Compound of claim 3 wherein R 2 is in the 2-position.
Claim 6
Dependent Claim
9 words
Compound of claim 3 wherein R is tert. butyl.
Claim 7
Dependent Claim
8 words
Compound of claim 1 having the formula ##STR18##
Claim 8
Dependent Claim
9 words
Compound of claim 6 wherein R is tert. butyl.
Claim 9
Dependent Claim
15 words
Compound of claim 6 wherein R 2 is in the 3, 4 or 6 position.
Claim 10
Dependent Claim
14 words
Compound of claim 6 wherein R 2 is in the 3 or 4 position.
Claim 11
Dependent Claim
8 words
Compound of claim 6 having the formula ##STR19##
Claim 12
Dependent Claim
10 words
The compound of claim 10 wherein R is tert. butyl.
Claim 13
Dependent Claim
15 words
The compound of claim 10 wherein R 2 is selected from --CF 3 , ##STR20##
Claim 14
Dependent Claim
15 words
The compound of claim 12 wherein R 1 is hydrogen and R is tert. butyl.
Claim 15
Dependent Claim
12 words
The compound of claim 13 wherein R 2 is --CF 3 .
Claim 16
Dependent Claim
10 words
The compound of claim 13 wherein R 2 is ##STR21##
Claim 17
Dependent Claim
10 words
The compound of claim 13 wherein R 2 is ##STR22##
Claim 18
Dependent Claim
10 words
The compound of claim 13 wherein R 2 is ##STR23##
Claim 19
Dependent Claim
9 words
The compound of claim 1 having the S-isomer configuration.
Claim 20
Dependent Claim
9 words
The compound of claim 1 having the R-isomer configuration.
Claim 21
Dependent Claim
21 words
Compound having the formula ##STR24## wherein R and R 2 are defined as in claim 1 and pharmaceutically acceptable salt thereof.
Claim 22
Dependent Claim
26 words
A method of treating hypertension in hypertensive humans which comprises oral, inhalation, suppository or parenteral administration of an effective amount of a compound of claim 1.
Claim 23
Dependent Claim
22 words
A pharmaceutical composition for treating hypertension comprising a therapeutically effective amount of a compound of claim 1 and pharmaceutically suitable compounding ingredient.
Claim 24
Dependent Claim
9 words
The compound of claim 14 having the S-isomer configuration.
Claim 25
Dependent Claim
9 words
The compound of claim 15 having the S-isomer configuration.
Claim 26
Dependent Claim
9 words
The compound of claim 16 having the S-isomer configuration.
Claim 27
Dependent Claim
9 words
The compound of claim 17 having the S-isomer configuration.
References Cited (Backward Citations)
US3946009A
Cited
US4000282A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-28 | 1981-05-30 | 1981-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-28 | 1985-05-30 | 1985-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-28 | 1989-05-30 | 1989-11-29 | $7700.00 | Window Closed / Lapsed |