US4000282A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
Assignee: Merck and Co Inc
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Filing: 1974-12-16
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Granted: 1976-12-28
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Expires: 1994-12-16
Abstract
Abstract Novel 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines, their pharmaceutically their preparation are disclosed. These pyridines are vasodilators having anti-hypertensive activity of rapid onset and extended duration and reduced tendency to cause undesirable tachychardia; they are also β-adrenergic blocking agents.
Inventors
- 👤 John J. Baldwin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 16:07
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/84; C07D213/85; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
17 words
Compounds having the formula ##STR6## wherein R is isopropyl or tert. butyl, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
17 words
Compounds having the formula ##STR6## wherein R is isopropyl or tert. butyl, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
8 words
Compounds of claim 1 wherein R is isopropyl.
Claim 4
Dependent Claim
9 words
Compounds of claim 1 wherein R is tert. butyl.
Claim 5
Dependent Claim
9 words
Compounds of claim 3 wherein said compounds are racemates.
Claim 6
Dependent Claim
12 words
Compounds of claim 3 wherein said compounds are in the rectus configuration.
Claim 7
Dependent Claim
12 words
Compounds of claim 3 wherein said compounds are in the sinister configuration.
Claim 8
Dependent Claim
11 words
The sinister form of 2-(3-tert. butylamino-2-hydroxypropoxy)-3-cyanopyridine and the hydrochloride salt thereof.
Claim 9
Dependent Claim
11 words
The sinister form of 2-(3-tert. butylamino-2-hydroxypropoxy)-3-cyanopyridine and the hydrochloride salt thereof.
Claim 10
Dependent Claim
18 words
Pharmaceutical composition comprising an antihypertensive amount of compound of claim 1 in combination with an acceptable pharmaceutical carrier.
Claim 11
Dependent Claim
22 words
Method of reducing blood pressure in hypertensive animals which comprises administering to said animals an effective amount of compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-12-28 | 1980-06-28 | 1980-12-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-12-28 | 1984-06-28 | 1984-12-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-12-28 | 1988-06-28 | 1988-12-28 | $7700.00 | Window Closed / Lapsed |