Abstract Cephalosporin antibiotics of the general formula <IMAGE> (I) (wherein Ra and Rb, which may be the same or different, each represent a C1-4 alkyl group or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene group; and R4 represents hydrogen or a 3- or 4-carbamoyl group) exhibit broad spectrum antibiotic activity, the activity being unusually high against gram-negative organisms such as strains of Pseudomonas organisms. A particular antibiotic compound of formula (I) possessing excellent antibacterial activity against strains of Pseudomonas organisms, as well as other valuable therapeutic properties, is (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimono) acetamido]-3-(1-pyridiniummethyl)-ceph-3-em-4 carboxylate. The invention also includes the non-toxic salts and non-toxic metabolically labile esters of compounds of formula (I). Also described are compositions containing the antibiotics of the invention and processes for the preparation of such antibiotics.
A cephalosporin antibiotic compound which is (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)acetamido]-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate or a non-toxic salt thereof.
Claim 2
Dependent Claim
12 words
A cephalosporin antibiotic compound which is (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)acetamido]-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate or a non-toxic salt thereof.
Claim 3
Dependent Claim
9 words
A non-toxic salt of the compound of claim 1.
Claim 4
Dependent Claim
9 words
The mono-sodium salt of the compound of claim 1.
Claim 5
Dependent Claim
8 words
The compound of claim 1 which is (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)acetamido]-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate.
Claim 6
Dependent Claim
29 words
A pharmaceutical composition for use in human or veterinary medicine comprising an effective amount of an antibiotic compound of claim 1 in association with a pharmaceutical carrier or excipient.
Claim 7
Dependent Claim
24 words
A method of combatting bacterial infection in a human or an animal comprising administering an antibacterially effective amount of a compound of claim 1.