US4166115A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Syn 7-oxoimino substituted derivatives of cephalosporanic acid
Assignee: Astellas Pharma Inc
•
Filing: 1977-02-11
•
Granted: 1979-08-28
•
Expires: 1997-02-11
Abstract
Abstract The present invention relates to new syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof. More particularly, it relates to new syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have antibacterial activities and to processes for the preparation thereof, to pharmaceutical composition comprising the same, and to a method of using the same therapeutically in the treatment of infectious diseases in human beings and animals.
Inventors
- 👤 Takao Takaya
- 👤 Takashi Masugi
- 👤 Hisashi Takasugi
- 👤 Hiromu Kochi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 16:16
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/02; C07D277/20; C07D277/32; C07D277/38; C07D277/44; C07D277/46; C07D277/48; C07D277/587; C07D333/00; C07D333/02; C07D333/04; C07D333/06; C07D333/14; C07D333/16; C07D501/00; C07D501/14; C07D501/16; C07D501/18
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
33 words
Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds of the formula: ##STR24## wherein R 2 is lower alkyl; R 3 is carboxy or protected carboxy; and R 4 is lower alkanoyloxymethyl; and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
33 words
Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds of the formula: ##STR24## wherein R 2 is lower alkyl; R 3 is carboxy or protected carboxy; and R 4 is lower alkanoyloxymethyl; and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
11 words
The compounds of claim 1, in which R 3 is carboxy.
Claim 4
Dependent Claim
11 words
The compounds of claim 2, in which R 1 is ##STR25##
Claim 5
Dependent Claim
15 words
The compound of claim 3, which is 7-[2-methoxyimino-2-(3-hydroxyphenyl)acetamido]cephalosporanic acid (syn isomer) and its sodium salt.
Claim 6
Dependent Claim
20 words
A pharmaceutical composition comprising a compound of claim 1 in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient.
References Cited (Backward Citations)
US3641021A
Cited
DE2204060A1
Cited
US3867380A
Cited
DE2223375A1
Cited
US4024137A
Cited
US3946001A
Cited
DE2556736A1
Cited
US4091213A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-27 | 1983-02-26 | 1983-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-27 | 1987-02-26 | 1987-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-27 | 1991-02-26 | 1991-08-28 | $7700.00 | Window Closed / Lapsed |