3-Carbamoyloxymethyl-7-substituted oximino acetamido cephalosporanic acid derivatives

Abstract

Abstract 3-Carbamoyloxymethyl and 3-N-methylcarbamoyloxymethyl cephalosporin antibiotics in which the 7β-acylamido group has the structure ##STR1## where R is thienyl, furyl or phenyl; R a is C 1-4 alkyl, C 2-4 alkenyl, C 3-7 cycloalkyl or phenyl, and R b is hydrogen, carboxy, C 2 -C 5 carbalkoxy or any of the groups designated for R a , or R a and R b together with the carbon atom to which they are attached form a C 3-7 cycloalkylidene or cycloalkenylidene group; exhibit broad spectrum antibiotic activity characterized by particularly high activity against gram negative microorganisms, including those which produce β-lactamases. The compounds, which are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer, have particularly high in vitro activity against strains of Escherichia coli, Haemophilus influenzae and Proteus organisms; and also shown unusually high activity against Pseudomonas organisms.

Inventors

• 👤 Janice Bradshaw
• 👤 Martin C. Cook
• 👤 Gordon I. Gregory

Bibliographic Details