Patent US4242347A successfully refreshed from Google Patents.
US4242347A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hypotensive indolylalkylpiperidyl guanidines and isoureas
Assignee: Novartis Corp
•
Filing: 1979-06-18
•
Granted: 1980-12-30
•
Expires: 1999-06-18
Abstract
Abstract 1-(Indolyl-3-alkyl)-3 or 4-(ureido or guanidino)-piperidines, e.g. those of the formula ##STR1## R=H; alkyl; free, etherified or esterified OH or SH; CF 3 , NO 2 or NH 2 m=1-4; n=2 or 3; X=O, S or NH acyl derivatives and salts thereof are antihypertensive agents.
Inventors
- 👤 Charles F. Huebner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:37
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/75; C07C; C07C29/00; C07C29/132; C07C29/136; C07C29/147; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/12; C07D209/30; C07D209/32; C07D209/34; C07D209/42; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/56; C07D211/58; C07D211/68; C07D211/72
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
99 words
A compound of the formula ##STR14## wherein Ph is unsubstituted 1,2-phenylene or 1,2-phenylene substituted by one member selected from lower alkyl, hydroxy, mercapto, lower alkoxy, lower alkylenedioxy having 1 or 2 carbon atoms, benzyloxy, lower alkylmercapto, halogeno, trifluoromethyl, nitro and amino; each of R 1 , R 2 , R 3 and R 4 is hydrogen or lower alkyl; X' is O-lower alkyl, S-lower alkyl, NH 2 or NH-lower-alkyl; m is an integer from 1 to 7; each of p and q is an integer from 1 to 3, but (p+q)=4; or a therapeutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
99 words
A compound of the formula ##STR14## wherein Ph is unsubstituted 1,2-phenylene or 1,2-phenylene substituted by one member selected from lower alkyl, hydroxy, mercapto, lower alkoxy, lower alkylenedioxy having 1 or 2 carbon atoms, benzyloxy, lower alkylmercapto, halogeno, trifluoromethyl, nitro and amino; each of R 1 , R 2 , R 3 and R 4 is hydrogen or lower alkyl; X' is O-lower alkyl, S-lower alkyl, NH 2 or NH-lower-alkyl; m is an integer from 1 to 7; each of p and q is an integer from 1 to 3, but (p+q)=4; or a therapeutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
21 words
A hypotensive pharmaceutical composition comprising a pharmacologically effective amount of a compound claimed in claim 1, together with a pharmaceutical excipient.
Claim 4
Dependent Claim
27 words
A method for reducing the blood pressure in mammals, which comprises administering to them enterally or parenterally an effective amount of a composition claimed in claim 2.
References Cited (Backward Citations)
US3188313A
Cited
US3527761A
Cited
US3642803A
Cited
US3655674A
Cited
DE2302717A1
Cited
GB1424354A
Cited
DE2447947A1
Cited
US4061641A
Cited
US4039670A
Cited
US3948918A
Cited
US4147786A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-30 | 1984-06-30 | 1984-12-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-30 | 1988-06-30 | 1988-12-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-30 | 1992-06-30 | 1992-12-30 | $7700.00 | Window Closed / Lapsed |