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US4061641A Expired / Lapsed US ⏱️ 0.0 years remaining

Ureidopiperidino-ketoalkyl indoles

Assignee: John Wyeth and Brother Ltd
•
Filing: 1976-07-15
•
Granted: 1977-12-06
•
Expires: 1996-07-15
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Abstract

Abstract The invention provides compounds of general formula I ##STR1## and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R represents hydrogen or lower alkyl, R 1 represents hydrogen or lower alkyl, R 2 represents hydrogen or lower alkyl, R 3 represents hydrogen, halogen, lower alkoxy, hydroxy, or lower alkyl, R 4 represents hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, thienyl, furyl, phenyl; phenyl mono- or disubstituted by halogen, lower alkyl, lower alkoxy, hydroxy or trifluoromethyl; or benzoyl, halobenzoyl, lower alkanoyl, cycloalkanoyl of 6 to 8 carbon atoms, or thienoyl, A represents an alkylene, mono- or diketo- or hydroxy-alkylene radical having from 1 to 5 carbon atoms and X is oxygen or sulphur. The compounds exhibit action on the cardiovascular system particularly hypotensive and/or anti-hypertensive activity.

Inventors

  • 👤 John Leheup Archibald
  • 👤 John Lambert Jackson

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-08 04:56
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/445

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 109 words
A compound of formula I ##STR13## and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R represents hydrogen or lower alkyl, R 1 represents hydrogen or lower alkyl, R 2 represents hydrogen or lower alkyl, R 3 represents hydrogen, halogen, lower alkoxy, hydroxy, or lower alkyl, R 4 represents hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, thienyl, furyl, phenyl; phenyl mono- or disubstituted by halogen, lower alkyl, lower alkoxy, hydroxy, or trifluoromethyl; or benzoyl, halobenzoyl, lower alkanoyl, cycloalkanoyl of 6 to 8 carbon atoms, or thienoyl, A represents a monoketoalkylene radical having from 1 to 5 carbon atoms and X is oxygen or sulphur.
Claim 2
Dependent Claim 109 words
A compound of formula I ##STR13## and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R represents hydrogen or lower alkyl, R 1 represents hydrogen or lower alkyl, R 2 represents hydrogen or lower alkyl, R 3 represents hydrogen, halogen, lower alkoxy, hydroxy, or lower alkyl, R 4 represents hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, thienyl, furyl, phenyl; phenyl mono- or disubstituted by halogen, lower alkyl, lower alkoxy, hydroxy, or trifluoromethyl; or benzoyl, halobenzoyl, lower alkanoyl, cycloalkanoyl of 6 to 8 carbon atoms, or thienoyl, A represents a monoketoalkylene radical having from 1 to 5 carbon atoms and X is oxygen or sulphur.
Claim 3
Dependent Claim 18 words
A compound as claimed in claim 1, which is 1-benzoyl-3-[1-(4-[3-indolyl]-4-oxobutyl)piperid-4-yl]urea or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim 18 words
A compound as claimed in claim 1, which is 1-(2-thienoyl)-3-[1-(4-[3-indolyl]oxobutyl-piperid-4-yl]urea or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim 18 words
A compound as claimed in claim 1, which is 1-[1(4-[3-indolyl]-4-oxobutyl)piperid-4-yl]-3-phenylurea or a pharmaceutically acceptable acid addition salt thereof.

References Cited (Backward Citations)

US3183235A Cited
US3527761A Cited
US3217011A Cited
US3655674A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-12-05 1981-06-06 1981-12-06 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-12-05 1985-06-06 1985-12-06 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-12-05 1989-06-06 1989-12-06 $7700.00 Window Closed / Lapsed

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