US3948918A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-[1-(Indol-3-ylethyl)-piperazin-4-yl]-3-substituted ureas
Assignee: CNA Holdings LLC
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Filing: 1974-05-31
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Granted: 1976-04-06
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Expires: 1994-05-31
Abstract
Abstract 1-[1-(Indol-3-ylethyl)-piperazin-4-yl]-3-substituted urea compounds, their physiologically tolerable acid addition salts, and a process for the preparation thereof are described. The compounds are useful as antihypertensive agents.
Inventors
- 👤 Edward J. Glamkowski
- 👤 Philip A. Reitano
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:37
CPC Classifications
C; C07; C07D; C07D403/00; C07D403/02; C07D403/04; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
92 words
A compound of the formula: ##SPC6## wherein R 1 and R 2 are hydrogen or alkoxy of from 1 to 3 carbon atoms; R 3 is hydrogen or alkyl of from 1 to 3 carbon atoms; and R 4 is alkyl of from 1 to 4 carbon atoms, cycloalkyl of from 3 to 8 carbon atoms; phenyl; or phenyl mono-, di-, or tri-substituted by halogen, alkyl of from 1 to 3 carbon atoms, alkoxy of from 1 to 2 carbon atoms, trifluoromethyl or nitro; and the physiologically tolerable acid addition salts thereof.
Claim 2
Dependent Claim
92 words
A compound of the formula: ##SPC6## wherein R 1 and R 2 are hydrogen or alkoxy of from 1 to 3 carbon atoms; R 3 is hydrogen or alkyl of from 1 to 3 carbon atoms; and R 4 is alkyl of from 1 to 4 carbon atoms, cycloalkyl of from 3 to 8 carbon atoms; phenyl; or phenyl mono-, di-, or tri-substituted by halogen, alkyl of from 1 to 3 carbon atoms, alkoxy of from 1 to 2 carbon atoms, trifluoromethyl or nitro; and the physiologically tolerable acid addition salts thereof.
Claim 3
Dependent Claim
41 words
A compound as defined in claim 1 in which R 1 and R 2 are hydrogen or methoxy, R 3 is hydrogen, methyl or ethyl, and R 4 is ethyl, butyl or cyclohexy, and the physiologically tolerable acid addition salts thereof.
Claim 4
Dependent Claim
40 words
A compound as defined in claim 1 in which R 1 and R 2 are hydrogen or methoxy, R 3 is hydrogen or methyl, and R 4 is phenyl, chlorophenyl, fluorophenyl, tolyl, and the physiologically tolerable acid addition salts thereof.
Claim 5
Dependent Claim
17 words
The compound defined in claim 2 which is 1-[1-(indol-3-ylethyl)piperazin-4-yl]-3-ethylurea and the physiologically tolerable acid addition salts thereof.
Claim 6
Dependent Claim
17 words
The compound defined in claim 3 which is 1-[1-(indol-3-ylethyl)piperazin-4-yl]-3-phenylurea and the physiologically tolerable acid addition salts thereof.
Claim 7
Dependent Claim
17 words
The compound defined in claim 3 which is 1-[1-(indol-3-ylethyl)piperazin-4-yl]-3-p-fluorophenylurea and the physiologically tolerable acid addition salts thereof.
Claim 8
Dependent Claim
17 words
The compound defined in claim 3 which is 1-[1-(5,6-dimethoxy-2-methylindol-3-ylethyl)piperazin-4-yl]-3-phenylurea and the physiologically tolerable acid addition salts thereof.
References Cited (Backward Citations)
US2663707A
Cited
US3188313A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-06 | 1979-10-06 | 1980-04-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-06 | 1983-10-06 | 1984-04-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-06 | 1987-10-06 | 1988-04-06 | $7700.00 | Window Closed / Lapsed |