US4231928A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibacterial agents
Assignee: Bristol Myers Co
•
Filing: 1979-04-24
•
Granted: 1980-11-04
•
Expires: 1999-04-24
Abstract
Abstract The penicillins of the formulae ##STR1## in which R 1 is phenyl, 2-thienyl, 3-thienyl, cyclohexyl, cyclohexen-1-yl, cyclohexa-1,4-dienyl, cyclohexa-1,4-dienylmethyl, 4-methoxycyclohexa-1,4-dienylmethyl or one of certain 4-substituted or 3,4-disubstituted phenyl moieties, and their pharmaceutically acceptable salts and physiologically hydrolyzed esters possess antibacterial activity and are particularly valuable in treating Pseudomonas infections.
Inventors
- 👤 Takayuki Naito
- 👤 Jun Okumura
- 👤 Hajime Kamachi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 13:42
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; C07D499/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
17 words
A compound having the formula ##STR35## or a pharmaceutically acceptable salt or conventional physiologically hydrolyzed ester thereof.
Claim 2
Dependent Claim
17 words
A compound having the formula ##STR35## or a pharmaceutically acceptable salt or conventional physiologically hydrolyzed ester thereof.
Claim 3
Dependent Claim
28 words
A compound of claim 1 having the structure Ib and having the D-configuration in the 6-side chain, or a pharmaceutically acceptable salt or conventional physiologically hydrolyzed ester thereof.
Claim 4
Dependent Claim
2 words
6-[D-(-)-α-Phenyl-α-(7-hydroxy-4-oxo-4H-pyrimido[1,2-b]pyridazin-3-ylcarboxamido)acetamido]penicillanic acid.
Claim 5
Dependent Claim
2 words
6-[D-(-)-α-Phenyl-α-(7-hydroxy-4-oxo-4H-pyrimido[1,2-b]pyridazin-3-ylcarboxamido)acetamido]penicillanic acid.
Claim 6
Dependent Claim
9 words
The sodium salt of the compound of claim 3.
Claim 7
Dependent Claim
9 words
The potassium salt of the compound of claim 3.
Claim 8
Dependent Claim
9 words
The pivaloyloxymethyl ester of the compound of claim 3.
Claim 9
Dependent Claim
9 words
The acetoxymethyl ester of the compound of claim 3.
Claim 10
Dependent Claim
9 words
The methoxymethyl ester of the compound of claim 3.
Claim 11
Dependent Claim
9 words
The phthalidyl ester of the compound of claim 3.
Claim 12
Dependent Claim
2 words
6-[D-(-)-α-(4-Hydroxyphenyl)-α-(7-hydroxy-4-oxo-4H-pyrimido[1,2-b]pyridazin-3-ylcarboxamido)acetamido]-penicillanic acid.
Claim 13
Dependent Claim
2 words
6-[D-(-)-α-(4-Hydroxyphenyl)-α-(7-hydroxy-4-oxo-4H-pyrimido[1,2-b]pyridazin-3-ylcarboxamido)acetamido]-penicillanic acid.
Claim 14
Dependent Claim
9 words
The sodium salt of the compound of claim 10.
Claim 15
Dependent Claim
9 words
The potassium salt of the compound of claim 10.
Claim 16
Dependent Claim
9 words
The pivaloyloxymethyl ester of the compound of claim 10.
Claim 17
Dependent Claim
9 words
The acetoxymethyl ester of the compound of claim 10.
Claim 18
Dependent Claim
9 words
The methoxymethyl ester of the compound of claim 10.
Claim 19
Dependent Claim
9 words
The phthalidyl ester of the compound of claim 10.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-04 | 1984-05-05 | 1984-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-04 | 1988-05-05 | 1988-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-04 | 1992-05-05 | 1992-11-04 | $7700.00 | Window Closed / Lapsed |