Ampicillin derivatives substituted by heterocyclic acyl group

Abstract

Abstract The ampicillin derivatives represented by the general formula WHEREIN R represents WHEREIN R' represents a hydrogen atom, a methyl group, or an ethyl group and A and B each represents a hydrogen atom, a hydroxyl group, a methyl group, a methoxy group, a nitro group, or a halogen atom and further said B may combine with A on the carbon atom at the position to form GROUP (WHERE IN Z represents -CH=N- or -CH=CH- and an R2 represents a hydrogen atom, a hydroxyl group, a phenyl group, a methyl group, an ethyl group, a methoxy group, an ethoxyl group, a methylthio group, a trifluoromethyl group, a halogen atom, a nitro group, an acetyl group, an acetamido group, a ethoxycarbonyloxy group, or a methylsulfonyl group and further R2 and MAY FORM A THIAZOLE, ISOTHIAZOLO, PYRROLO, FURO, OR BENZO FUSED RING WHICH MAY BE SUBSTITUTED BY AN OXO GROUP, A METHYL GROUP, OR AN ACETYL GROUP) AND THE DOTTED LINE MEANS AN ARBITRARY DOUBLE BOND, WHEREIN R3 and R4 each represents a hydrogen atom or a methyl group, WHEREIN R5 represents a halogen atom, a methoxy group, a nitro group, or a hydroxyl group and R6 represents a hydrogen atom, a methoxy group, a halogen atom, a nitro group, or a hydroxyl group, or WHEREIN R7 represents a hydrogen atom or a hydroxyl group, Y represents O or S, and the dotted line means an arbitrary double bond, said substituent group, being bonded to the ampicillin molecule through -CO- at the 2-position, 3-position, 5-position or 6-position when the oxo group (+0) is at the 4-portion and being bonded to the ampicillin molecule through the -CO- group at the 2-position, 4-position, or 5-position when the oxy group is at the 6-position, and salts of the ampicillin derivatives.

Inventors

• 👤 Masuo Murakami
• 👤 Ichiro Isaka
• 👤 Akio Koda
• 👤 Norio Kawahara
• 👤 Teruya Ashiwagi
• 👤 Yukiyasu Murakami
• 👤 Kuniichiro Yano
• 👤 Kohzi Nakano
• 👤 Isao Souzo

Bibliographic Details