US3954733A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Naphthyridine-3-carboxamido-benzylpenicillins and salts thereof
Assignee: Sumitomo Chemical Co Ltd
•
Filing: 1973-12-13
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Granted: 1976-05-04
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Expires: 1993-12-13
Abstract
Abstract Novel penicillins of the formula:
Inventors
- 👤 Hisao Tobiki
- 👤 Hirotada Yamada
- 👤 Iwao Nakatsuka
- 👤 Kozo Shimago
- 👤 Shigeru Okano
- 👤 Takenari Nakagome
- 👤 Toshiaki Komatsu
- 👤 Akio Izawa
- 👤 Hiroshi Noguchi
- 👤 Yasuko Eda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:40
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; C07D499/00
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
93 words
A compound of the formula: ##SPC24## wherein the ring A is an unsubstituted pyridine ring or a pyridine ring having one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, lower haloalkyl, lower alkylenedioxy, halogen, hydroxyl, nitro, amino, lower alkoxycarbonylamino, lower alkylamino, di(lower) alkylamino and lower alkanoylamino, X is oxygen or sulfur, Y is hydrogen, lower alkoxycarbonyl or lower alkanoyl, R 1 is hydroxyl, lower alkanoyloxy, lower alkoxycarbonyloxy or benzyloxycarbonyloxy and R 2 and R 3 are each hydrogen or halogen, and nontoxic pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
93 words
A compound of the formula: ##SPC24## wherein the ring A is an unsubstituted pyridine ring or a pyridine ring having one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, lower haloalkyl, lower alkylenedioxy, halogen, hydroxyl, nitro, amino, lower alkoxycarbonylamino, lower alkylamino, di(lower) alkylamino and lower alkanoylamino, X is oxygen or sulfur, Y is hydrogen, lower alkoxycarbonyl or lower alkanoyl, R 1 is hydroxyl, lower alkanoyloxy, lower alkoxycarbonyloxy or benzyloxycarbonyloxy and R 2 and R 3 are each hydrogen or halogen, and nontoxic pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
33 words
The compound according to claim 1, wherein the ring A is an unsubstituted pyridine ring or a pyridine ring substituted with one or more of dimethylamino, methyl, methylthio, methoxy, hydroxyl, acetylamino and amino.
Claim 4
Dependent Claim
32 words
The compound according to claim 2, wherein R 1 is a hydroxyl group or an ethoxycarbonyloxy group and R 2 and R 3 are each a hydrogen atom or a chlorine atom.
Claim 5
Dependent Claim
79 words
A compound of the formula: ##SPC25## wherein the ring A is an unsubstituted pyridine ring or a pyridine ring having one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, lower haloalkyl, lower alkylenedioxy, halogen, hydroxyl, nitro, amino, lower alkoxycarbonylamino, lower alkylamino, di(lower)alkylamino and lower alkanoylamino, R 1 is hydroxyl, lower alkanoyloxy, lower alkoxycarbonyloxy or benzyloxycarbonyloxy and R 2 and R 3 are each hydrogen or halogen, and nontoxic pharmaceutically acceptable salts thereof.
Claim 6
Dependent Claim
79 words
A compound of the formula: ##SPC25## wherein the ring A is an unsubstituted pyridine ring or a pyridine ring having one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, lower haloalkyl, lower alkylenedioxy, halogen, hydroxyl, nitro, amino, lower alkoxycarbonylamino, lower alkylamino, di(lower)alkylamino and lower alkanoylamino, R 1 is hydroxyl, lower alkanoyloxy, lower alkoxycarbonyloxy or benzyloxycarbonyloxy and R 2 and R 3 are each hydrogen or halogen, and nontoxic pharmaceutically acceptable salts thereof.
Claim 7
Dependent Claim
80 words
A compound of the formula: ##SPC26## wherein the ring A is an unsubstituted pyridine ring or a pyridine ring having one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, lower alkanoylamino, hydroxyl, di(lower)alkylamino and amino, X is oxygen or sulfur, Y is hydrogen, lower alkoxycarbonyl or lower alkanoyl, R 1 is hydroxyl, lower alkoxycarbonyloxy or benzyloxycarbonyloxy and R 2 and R 3 are each hydrogen or halogen, and non-toxic pharmaceutically acceptable salts thereof.
Claim 8
Dependent Claim
80 words
A compound of the formula: ##SPC26## wherein the ring A is an unsubstituted pyridine ring or a pyridine ring having one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, lower alkanoylamino, hydroxyl, di(lower)alkylamino and amino, X is oxygen or sulfur, Y is hydrogen, lower alkoxycarbonyl or lower alkanoyl, R 1 is hydroxyl, lower alkoxycarbonyloxy or benzyloxycarbonyloxy and R 2 and R 3 are each hydrogen or halogen, and non-toxic pharmaceutically acceptable salts thereof.
Claim 9
Dependent Claim
12 words
The compound according to claim 1, wherein Y is a hydrogen atom.
Claim 10
Dependent Claim
39 words
The compound according to claim 1, wherein R 1 is a hydroxyl group, a C 1 -C 6 alkoxycarbonyloxy group or a benzyloxycarbonyloxy group and R 2 and R 3 are each a hydrogen atom or a chlorine atom.
Claim 11
Dependent Claim
7 words
D-α-(4-Hydroxy-1,5-naphthyridine-3-carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 12
Dependent Claim
7 words
D-α-(4-Hydroxy-1,5-naphthyridine-3-carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 13
Dependent Claim
7 words
D-α-(4-Ethoxycarbonyloxy-1,5-naphthyridine-3-carboxamido)-p-benzyloxycarbonyloxybenzylpenicillin and nontoxic, pharmaceutically acceptable salts thereof.
Claim 14
Dependent Claim
7 words
D-α-(4-Ethoxycarbonyloxy-1,5-naphthyridine-3-carboxamido)-p-benzyloxycarbonyloxybenzylpenicillin and nontoxic, pharmaceutically acceptable salts thereof.
Claim 15
Dependent Claim
7 words
D-α-(4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 16
Dependent Claim
7 words
D-α-(4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 17
Dependent Claim
7 words
D-α-(4-Hydroxy-1,5-naphthyridine-3-carboxamido)-p-ethoxycarbonyloxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 18
Dependent Claim
7 words
D-α-(4-Hydroxy-1,5-naphthyridine-3-carboxamido)-p-ethoxycarbonyloxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 19
Dependent Claim
7 words
D-α-(4-Hydroxy-1,5-naphthyridine-3-carboxamido)-m-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 20
Dependent Claim
7 words
D-α-(4-Hydroxy-1,5-naphthyridine-3-carboxamido)-m-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 21
Dependent Claim
7 words
D-α-(4-Hydroxy-6-methyl-1,5-naphthyridine-3carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 22
Dependent Claim
7 words
D-α-(4-Hydroxy-6-methyl-1,5-naphthyridine-3carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 23
Dependent Claim
7 words
D-α-(4,6-Dihydroxy-1,5-naphthyridine-3-carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 24
Dependent Claim
7 words
D-α-(4,6-Dihydroxy-1,5-naphthyridine-3-carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 25
Dependent Claim
7 words
D-α-(6-Amino-4-hydroxy-1,5-naphthyridine-3-carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 26
Dependent Claim
7 words
D-α-(6-Amino-4-hydroxy-1,5-naphthyridine-3-carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 27
Dependent Claim
7 words
D-α-(4-Hydroxy-1,5-naphthyridine-3-carboxamido)-m-chloro-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salt thereof.
Claim 28
Dependent Claim
7 words
D-α-(4-Hydroxy-1,5-naphthyridine-3-carboxamido)-m-chloro-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salt thereof.
Claim 29
Dependent Claim
7 words
D-α-(4-Ethoxycarbonyloxy-1,5-naphthyridine-3-carboxamido)-p-ethoxycarbonyloxybenzylpenicillin and nontoxic, pharmaceutically acceptable salts thereof.
Claim 30
Dependent Claim
7 words
D-α-(4-Ethoxycarbonyloxy-1,5-naphthyridine-3-carboxamido)-p-ethoxycarbonyloxybenzylpenicillin and nontoxic, pharmaceutically acceptable salts thereof.
Claim 31
Dependent Claim
7 words
D-α-(4-Mercapto-1,5-naphthyridine-3-carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
Claim 32
Dependent Claim
7 words
D-α-(4-Mercapto-1,5-naphthyridine-3-carboxamido)-p-hydroxybenzylpenicillin and non-toxic, pharmaceutically acceptable salts thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-04 | 1979-11-03 | 1980-05-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-04 | 1983-11-03 | 1984-05-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-04 | 1987-11-03 | 1988-05-04 | $7700.00 | Window Closed / Lapsed |