US3873523A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Derivatives of ampicillin
Assignee: Parke Davis and Co LLC
•
Filing: 1972-12-15
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Granted: 1975-03-25
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Expires: 1992-12-15
Abstract
Abstract Novel organic amide compounds which are substituted N-(1,2dihydro-2-oxonicotinyl)-ampicillins, -cephalexins and cephaloglycins having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid ampicillin, cephalexin or cephaloglycin or the acid salt or silyated derivative thereof with a reactive derivative of the corresponding 1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-aminopenicillanic acid, 7-aminocephalosporanic acid or 7-amino-3-methylceph-3-em-4-carboxylic acid or the acid salt or silyated derivative thereof with a reactive derivative of the corresponding N-(1,2-dihydro-2-oxonicotinyl)-2phenylglycine.
Inventors
- 👤 Leonard Doub
- 👤 James S Kaltenbronn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 09:00
CPC Classifications
C; C07; C07D; C07D499/00; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/79; C07D213/80; C07D213/84; C07D213/85; C07D221/00; C07D221/02; C07D221/04; C07D221/06; C07D221/16
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
5 words
AMIDE COMPOUNDS HAVING THE FORMULA
Claim 2
Dependent Claim
5 words
AMIDE COMPOUNDS HAVING THE FORMULA
Claim 3
Dependent Claim
14 words
A compound according to claim 1 in the form of a free carboxylic acid.
Claim 4
Dependent Claim
14 words
A compound according to claim 1 in the form of an alkali metal salt.
Claim 5
Dependent Claim
11 words
A compound according to claim 1 which is N-(6-(2-cyclopentenylmethyl)-1,2-dihydro-2-oxonicotinyl)ampicillin, sodium salt.
Claim 6
Dependent Claim
12 words
A compound according to claim 1 which is N-(6-(2-pyridyl)-1, 2-dihydro-2-oxonicotinyl)ampicillin, sodium salt.
Claim 7
Dependent Claim
12 words
A compound according to claim 1 which is N-(6-(3-pyridyl)-1, 2-dihydro-2-oxonicotinyl)ampicillin, sodium salt.
Claim 8
Dependent Claim
12 words
A compound according to claim 1 which is N-(6-(4-pyridyl)-1, 2-dihydro-2-oxonicotinyl)ampicillin, sodium salt.
Claim 9
Dependent Claim
12 words
A compound according to claim 1 which is N-(6-(2-thienyl)-1, 2-dihydro-2-oxonicotinyl)ampicillin, triethylamine salt.
Claim 10
Dependent Claim
12 words
A compound according to claim 1 which is N-(6-(2-thienyl)-1, 2-dihydro-2-oxonicotinyl)ampicillin, sodium salt.
References Cited (Backward Citations)
US3697507A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-24 | 1978-09-23 | 1979-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-24 | 1982-09-23 | 1983-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-24 | 1986-09-23 | 1987-03-25 | $7700.00 | Window Closed / Lapsed |