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US4228077A
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N-[2-(mercaptoalkyl)-3-mercaptoalkanoyl]-l-tryptophanes
Assignee: ER Squibb and Sons LLC
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Filing: 1978-03-24
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Granted: 1980-10-14
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Expires: 1998-03-24
Abstract
Abstract New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors. The compounds claimed in this application are those wherein B is indolyl-lower alkylene.
Inventors
- 👤 Miguel A. Ondetti
- 👤 Frank L. Weisenborn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 10:33
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/60; C07C; C07C323/00; C07C327/00; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
74 words
A compound of the formula ##STR19## and physiologically acceptable basic salts thereof, wherein R 1 is hydroxy or lower alkoxy; R 2 is hydrogen, lower alkyl or lower alkanoyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkanoyl, or benzoyl A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is ##STR20## X is oxygen or sulfur; m is zero, 1, 2, 3 or 4; and n is zero or 1.
Claim 2
Dependent Claim
74 words
A compound of the formula ##STR19## and physiologically acceptable basic salts thereof, wherein R 1 is hydroxy or lower alkoxy; R 2 is hydrogen, lower alkyl or lower alkanoyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkanoyl, or benzoyl A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is ##STR20## X is oxygen or sulfur; m is zero, 1, 2, 3 or 4; and n is zero or 1.
Claim 3
Dependent Claim
8 words
A compound as in claim 1 wherein ##STR21##
Claim 4
Dependent Claim
57 words
A compound as in claim 1 wherein R 1 is hydroxy; R 2 is hydrogen, lower alkyl, or lower akanoyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkanoyl or benzoyl; X is oxygen or sulfur; A is hydrogen; B is ##STR22## m is zero or 1; and n is zero or 1.
Claim 5
Dependent Claim
10 words
A compound as in claim 1 wherein X is oxygen.
Claim 6
Dependent Claim
10 words
A compound as in claim 1 wherein X is sulfur.
Claim 7
Dependent Claim
36 words
A compound as in claim 1 wherein R 1 is hydroxy; A, R 2 , R 3 and R 4 each is hydrogen; B is indol-3-ylmethyl; X is sulfur; and m and n each is 1.
References Cited (Backward Citations)
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Cited
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US3624143A
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US3843796A
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Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-14 | 1984-04-14 | 1984-10-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-14 | 1988-04-14 | 1988-10-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-14 | 1992-04-14 | 1992-10-14 | $7700.00 | Window Closed / Lapsed |