US4210557A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Non-high density lipoprotein precipitant
Assignee: Beckman Coulter Inc
•
Filing: 1978-12-15
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Granted: 1980-07-01
•
Expires: 1998-12-15
Abstract
Abstract A reagent, of the type comprising a precipitator capable of precipitating low density lipoproteins, very low density lipoproteins, and other non-high density lipoproteins, is improved by the addition thereto of a non-interfering suitable agent capable of enhancing the flocculation of a precipitant formed by the precipitator and the various non-high density lipoprotein fractions in highly lipemic serum.
Inventors
- 👤 Gerald J. Handschuh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 19:59
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/92; G01N2800/00; G01N2800/04; G01N2800/044; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/104165; Y10T436/107497
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
67 words
In a reagent comprising a non-high density lipoprotein precipitator capable of precipitating low density lipoproteins, very low density lipoproteins, and other non-high density lipoproteins, the improvement wherein said reagent further comprises an inert, water-insoluble, adsorptive agent which is non-interfering with analysis of HDL cholesterol and capable of enhancing the flocculation of a precipitant formed by said precipitator and said non-high density lipoprotein fractions in highly lipemic serum.
Claim 2
Dependent Claim
67 words
In a reagent comprising a non-high density lipoprotein precipitator capable of precipitating low density lipoproteins, very low density lipoproteins, and other non-high density lipoproteins, the improvement wherein said reagent further comprises an inert, water-insoluble, adsorptive agent which is non-interfering with analysis of HDL cholesterol and capable of enhancing the flocculation of a precipitant formed by said precipitator and said non-high density lipoprotein fractions in highly lipemic serum.
Claim 3
Dependent Claim
31 words
The reagent of claim 1 wherein said inert, insoluble, adsorptive agent is selected from a group consisting of silicic acid; kaolin; calcined alumina; talc; activated charcoal; powdered glass; and mixtures thereof.
Claim 4
Dependent Claim
23 words
The reagent of claim 2 wherein said inert, insoluble, adsorptive agent is selected from the group consisting of talc, kaolin, and mixtures thereof.
Claim 5
Dependent Claim
13 words
The reagent of claim 3 wherein said inert, insoluble, adsorptive agent is talc.
Claim 6
Dependent Claim
14 words
The reagent of claim 1 wherein said precipitator comprises dextran sulfate and magnesium cations.
Claim 7
Dependent Claim
14 words
The reagent of claim 2 wherein said precipitator comprises dextran sulfate and magnesium cations.
Claim 8
Dependent Claim
14 words
The reagent of claim 3 wherein said precipitator comprises dextran sulfate and magnesium cations.
Claim 9
Dependent Claim
14 words
The reagent of claim 4 wherein said precipitator comprises dextran sulfate and magnesium cations.
Claim 10
Dependent Claim
10 words
A powdered reagent prepared from the reagent of claim 1.
Claim 11
Dependent Claim
10 words
A powdered reagent prepared from the reagent of claim 2.
Claim 12
Dependent Claim
10 words
A powdered reagent prepared from the reagent of claim 3.
Claim 13
Dependent Claim
10 words
A powdered reagent prepared from the reagent of claim 4.
Claim 14
Dependent Claim
10 words
A powdered reagent prepared from the reagent of claim 5.
Claim 15
Dependent Claim
10 words
A powdered reagent prepared from the reagent of claim 6.
Claim 16
Dependent Claim
10 words
A powdered reagent prepared from the reagent of claim 7.
Claim 17
Dependent Claim
10 words
A powdered reagent prepared from the reagent of claim 8.
Claim 18
Dependent Claim
9 words
A granular reagent comprising the reagent of claim 1.
Claim 19
Dependent Claim
9 words
A granular reagent comprising the reagent of claim 2.
Claim 20
Dependent Claim
9 words
A granular reagent comprising the reagent of claim 3.
Claim 21
Dependent Claim
9 words
A granular reagent comprising the reagent of claim 4.
Claim 22
Dependent Claim
9 words
A granular reagent comprising the reagent of claim 5.
Claim 23
Dependent Claim
9 words
A granular reagent comprising the reagent of claim 6.
Claim 24
Dependent Claim
9 words
A granular reagent comprising the reagent of claim 7.
Claim 25
Dependent Claim
9 words
A granular reagent comprising the reagent of claim 8.
Claim 26
Dependent Claim
8 words
A tablet comprising the reagent of claim 1.
Claim 27
Dependent Claim
8 words
A tablet comprising the reagent of claim 2.
Claim 28
Dependent Claim
8 words
A tablet comprising the reagent of claim 3.
Claim 29
Dependent Claim
8 words
A tablet comprising the reagent of claim 4.
Claim 30
Dependent Claim
8 words
A tablet comprising the reagent of claim 5.
Claim 31
Dependent Claim
8 words
A tablet comprising the reagent of claim 6.
Claim 32
Dependent Claim
8 words
A tablet comprising the reagent of claim 7.
Claim 33
Dependent Claim
8 words
A tablet comprising the reagent of claim 8.
Claim 34
Dependent Claim
36 words
The tablet of claim 25 comprising about 15 mg anhydrous magnesium acetate, about 1 mg of dextran sulfate, about 40 mg of talc, about 6 mg of derivatized starch, and about 38 mg of microcrystalline cellulose.
Claim 35
Dependent Claim
98 words
In a method of precipitating non-HDL cholesterol comprising contacting a non-HDL precipitator with a serum sample to be assayed, the improvement wherein said pre non-HDL precipitator employed therein is the reagent of claims 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-07-01 | 1983-12-31 | 1984-07-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-07-01 | 1987-12-31 | 1988-07-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-07-01 | 1991-12-31 | 1992-07-01 | $7700.00 | Window Closed / Lapsed |