Patent US4183916A successfully refreshed from Google Patents.
US4183916A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oral compositions
Assignee: GlaxoSmithKline LLC
•
Filing: 1978-03-31
•
Granted: 1980-01-15
•
Expires: 1998-03-31
Abstract
Abstract Oral compositions useful for controlling dental plaque and gingivitis and for preventing caries are produced comprising a cationic antimicrobial agent and an anti-stain agent which reduces the staining effect of the cationic antimicrobial.
Inventors
- 👤 Maria Rodon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 23:08
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/36; A61K8/365; A61K8/40; A61K8/41; A61K8/416; A61K8/43; A61K8/49; A61K8/4906; A61K8/4926; A61Q; A61Q11/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
82 words
An oral composition useful for controlling dental plaque and gingivitis and for preventing caries which comprises from 0.1% to about 1.0% w/w or w/v of a cationic antimicrobial agent otherwise tending to stain teeth, and useful for controlling dental plaque and gingivitis and for preventing caries selected from the group consisting of a bisbiguanide or quaternary ammonium compound and from 0.1% to 10.0% w/w or w/v of malic acid effective to inhibit said teeth staining, in combination with a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
82 words
An oral composition useful for controlling dental plaque and gingivitis and for preventing caries which comprises from 0.1% to about 1.0% w/w or w/v of a cationic antimicrobial agent otherwise tending to stain teeth, and useful for controlling dental plaque and gingivitis and for preventing caries selected from the group consisting of a bisbiguanide or quaternary ammonium compound and from 0.1% to 10.0% w/w or w/v of malic acid effective to inhibit said teeth staining, in combination with a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
20 words
A composition according to claim 1 wherein the amount of malic acid is from 0.1% to 1.0% w/w or w/v.
Claim 4
Dependent Claim
19 words
A composition according to claim 1 wherein the pH of the composition is from about 5.0 to about 8.0.
Claim 5
Dependent Claim
36 words
A composition according to claim 1 wherein the bisbiguanide is 1,6-bis(2-ethylhexyl diguanido hexane)dihydrochloride; 1,6-bis(2-ethylhexyl diguanido hexane)dihydrofluoride; 1,6-bis(2-ethylhexyl diguanido octane)dihydrochloride; 1,6-bis(2-ethylhexyl diguanido nonane)dihydrochloride; 1,6-bis(2-ethylhexyl diguanido dodecane)dihydrochloride; or 1,6-di(4-chlorophenyl diguanido hexane)dihydrochloride or the diacetate or digluconate salt thereof.
Claim 6
Dependent Claim
37 words
A composition according to claim 1 wherein the quaternary ammonium compound is dodecyl dimethyl-(2-phenoxyethyl)-ammonium; benzyldimethyl(2-)2-(p-1,3,3-tetramethyl butyl phenoxy)ethoxyl)ethyl)ammonium; p-bromobenzyl-dimethyl-γ-(2'-isopropyl, 4'-chloro, 5'-methyl phenoxy)-propyl ammonium; 1-hexadecyl-pyridinium salt; acylcholaminoformyl-methyl pyridinium chloride-iodide complex; 1-alkyl-4-aminoquinaldinium salt; decamethylene bis(4-aminoquinaldinum chloride) or hexadecamethylene bis(isoquinolinium chloride).
Claim 7
Dependent Claim
13 words
A composition according to claim 1 wherein the antimicrobial agent is alexidine dihydrochloride.
Claim 8
Dependent Claim
9 words
A composition according to claim 1 in mouthwash form.
Claim 9
Dependent Claim
10 words
A composition according to claim 1 in oral rinse form.
Claim 10
Dependent Claim
9 words
A composition according to claim 1 in dentifrice form.
Claim 11
Dependent Claim
9 words
A composition according to claim 1 in toothpowder form.
Claim 12
Dependent Claim
10 words
A composition according to claim 1 in oral solution form.
Claim 13
Dependent Claim
9 words
A composition according to claim 1 in gel form.
Claim 14
Dependent Claim
16 words
A composition according to claim 1 in a form suitable for dispensing through a water jet.
Claim 15
Dependent Claim
11 words
A composition according to claim 1 in a breath freshener form.
Claim 16
Dependent Claim
10 words
A composition according to claim 1 in an aerosol form.
Claim 17
Dependent Claim
10 words
A composition according to claim 1 in a gargle form.
Claim 18
Dependent Claim
12 words
A composition according to claim 1 in the form of a troche.
Claim 19
Dependent Claim
9 words
A composition according to claim 1 in lozenge form.
Claim 20
Dependent Claim
34 words
A composition according to claim 1 which comprises 0.035% w/v alexidine dihydrochloride, 0.382% w/v malic acid and purified water as the pharmaceutically acceptable carrier, the pH of the composition being between 5.0 and 8.0.
Claim 21
Dependent Claim
51 words
A composition according to claim 1 which comprises 0.035% w/v alexidine dihydrochloride, 15.0% w/v alcohol USP. 10.0% w/v glycerin USP, 0.04% w/v flavoring agent, 0.02% w/v sodium saccharin, 0.382% w/v malic acid, sufficient buffering agent to maintain the pH of the composition between 5.0 and 8.0 and purified water UPS, q.s.
References Cited (Backward Citations)
US3124506A
Cited
US1275275A
Cited
US3151028A
Cited
US3934002A
Cited
US4001393A
Cited
US3937807A
Cited
US3925543A
Cited
US3887701A
Cited
US4051234A
Cited
US4067962A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-01-14 | 1983-07-16 | 1984-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-01-14 | 1987-07-16 | 1988-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-01-14 | 1991-07-16 | 1992-01-15 | $7700.00 | Window Closed / Lapsed |