Patent US4174277A successfully refreshed from Google Patents.
US4174277A
Expired / Lapsed
US
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Resin and method for removing antimicrobials from body fluids
Assignee: Individual
•
Filing: 1978-09-25
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Granted: 1979-11-13
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Expires: 1998-09-25
Abstract
Abstract Microporous anionic exchange and non-ionic adsorbent resins which are capable of adsorbing an antibiotic and which have been coated with a non-ionic detergent are disclosed. When contacted with bacterially infected body-fluid specimens, the disclosed resins remove antibiotics from the specimen while exhibiting diminished bacterial adsorption. A combination of a disclosed detergent-coated non-functional adsorbent resin with a cationic resin removes other bacterial inhibitors, as well as antibiotics, from bacterially infected body fluid specimens while permitting the bacteria to remain in the specimens. By removing bacterial inhibitors while sparing the bacteria, the disclosed resins make possible rapid isolation and identification of an infecting organism.
Inventors
- 👤 Joseph L. Melnick
- 👤 Craig Wallis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 13:23
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/22; B01J20/26; B01J20/261; B01J20/262; B01J20/264; B01J20/28; B01J20/28054; B01J20/28078; B01J20/2808; B01J20/30; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3206; B01J20/3208; B01J20/321; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/3272; B01J47/00; B01J47/014; B01J47/016; C; C12; C12Q; C12Q1/00; C12Q1/02; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; B01J2220/00; B01J2220/50; B01J2220/58; Y; Y10; Y10S; Y10S424/00; Y10S424/07
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
62 words
A method for selectively removing an antibiotic from a bacterially infected body fluid specimen which comprises coating a microporous resin which is capable of adsorbing an antibiotic and is selected from the group consisting of anion exchange resins and non-functional adsorbent resins with a non-ionic detergent by fluidizing the resin with the non-ionic detergent, and thereafter contacting the specimen with the resin.
Claim 2
Independent Claim
62 words
A method for selectively removing an antibiotic from a bacterially infected body fluid specimen which comprises coating a microporous resin which is capable of adsorbing an antibiotic and is selected from the group consisting of anion exchange resins and non-functional adsorbent resins with a non-ionic detergent by fluidizing the resin with the non-ionic detergent, and thereafter contacting the specimen with the resin.
Claim 3
Dependent Claim
16 words
The method of claim 1 wherein the non-ionic detergent is a polyethylene glycol alkyl aryl ether.
Claim 4
Dependent Claim
14 words
The method of claim 1 wherein the resin is a non-functional polymeric resin adsorbent.
Claim 5
Dependent Claim
30 words
The method of claim 1 wherein the step of contacting the specimen with the resin is carried out by tumbling the resin with the specimen in a vertically rotating container.
Claim 6
Dependent Claim
13 words
The method of claim 1 wherein the resin is an anionic exchange resin.
Claim 7
Dependent Claim
20 words
The method of claim 1 wherein the resin is a non-functional copolymer of styrene and divinylbenzene having a macroreticular structure.
Claim 8
Dependent Claim
12 words
The method of claim 1 wherein the body fluid specimen is blood.
Claim 9
Dependent Claim
12 words
The method of claim 1 wherein the body fluid specimen is urine.
Claim 10
Dependent Claim
13 words
The method of claim 1 wherein the body fluid specimen is spinal fluid.
Claim 11
Independent Claim
69 words
A method for selectively removing an antibiotic from a bacterially infected body fluid specimen which comprises coating a microporous resin which is capable of adsorbing an antiobiotic and is selected from the group consisting of anion exchange resins and non-functional adsorbent resins with a non-ionic detergent by fluidizing the resin with non-ionic detergent and thereafter contacting the specimen with the detergent-coated resin, in combination with a cationic exchange resin.
Claim 12
Independent Claim
69 words
A method for selectively removing an antibiotic from a bacterially infected body fluid specimen which comprises coating a microporous resin which is capable of adsorbing an antiobiotic and is selected from the group consisting of anion exchange resins and non-functional adsorbent resins with a non-ionic detergent by fluidizing the resin with non-ionic detergent and thereafter contacting the specimen with the detergent-coated resin, in combination with a cationic exchange resin.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-11-12 | 1983-05-14 | 1983-11-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-11-12 | 1987-05-14 | 1987-11-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-11-12 | 1991-05-14 | 1991-11-13 | $7700.00 | Window Closed / Lapsed |