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US4173514A
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High mannitol process (enzymatic isomerization)
Assignee: SPI Polyols Inc
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Filing: 1977-06-02
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Granted: 1979-11-06
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Expires: 1997-06-02
Abstract
Abstract Mannitol-rich aqueous solutions of sorbitol and mannitol are prepared by a process which includes (1) epimerizing glucose in aqueous solution to obtain an epimerizate containing approximately 30 percent mannose and 70 percent glucose on the dry basis, (2) contacting this glucose-mannose epimerizate with a glucose isomerase enzyme to produce a glucose-fructose-mannose solution, and (3) hydrogenating this glucose-fructose-mannose solution to produce an aqueous solution of sorbitol and mannitol.
Inventors
- 👤 Walter M. Kruse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 05:46
CPC Classifications
C; C07; C07C; C07C31/00; C07C31/18; C07C31/26; C12; C12P; C12P19/00; C12P19/24
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
120 words
A process for obtaining a mannitol-rich solution of sorbitol and mannitol from glucose which comprises: (a) catalytically epimerizing glucose in an acidic aqueous solution in the presence of a hexa- valent molybdenum catalyst at a temperature not exceeding about 100° C., thereby obtaining a mixture of glucose and mannose in aqueous solution; (b) contacting said mixture of glucose and mannose in aqueous solution with a glucose isomerase enzyme under enzymatic isomerization conditions, whereby a portion of the glucose content of said mixture is isomerized and a mixture of glucose, fructose, and mannose in aqueous solution is formed; and (c) catalytically hydrogenating said mixture of glucose, fructose, and mannose in aqueous solution, thereby forming an aqueous solution containing sorbitol and mannitol.
Claim 2
Dependent Claim
120 words
A process for obtaining a mannitol-rich solution of sorbitol and mannitol from glucose which comprises: (a) catalytically epimerizing glucose in an acidic aqueous solution in the presence of a hexa- valent molybdenum catalyst at a temperature not exceeding about 100° C., thereby obtaining a mixture of glucose and mannose in aqueous solution; (b) contacting said mixture of glucose and mannose in aqueous solution with a glucose isomerase enzyme under enzymatic isomerization conditions, whereby a portion of the glucose content of said mixture is isomerized and a mixture of glucose, fructose, and mannose in aqueous solution is formed; and (c) catalytically hydrogenating said mixture of glucose, fructose, and mannose in aqueous solution, thereby forming an aqueous solution containing sorbitol and mannitol.
Claim 3
Dependent Claim
19 words
A process according to claim 1 in which said glucose is epimerized at a temperature of about 90°-100° C.
Claim 4
Dependent Claim
15 words
A process according to claim 2 in which said hexavalent molybdenum catalyst is molybdic acid.
Claim 5
Dependent Claim
31 words
A process according to claim 1 in which said mixture of glucose and mannose in aqueous solution is passed through a column of whole Arthrobacter cells containing said glucose isomerase enzyme.
Claim 6
Dependent Claim
21 words
A process according to claim 1 in which said mixture of glucose, fructose and mannose is catalytically hydrogenated under non-alkaline conditions.
Claim 7
Dependent Claim
24 words
A process according to claim 1 in which said mixture of glucose, fructose, and mannose is hydrogenated in the presence of a nickel catalyst.
Claim 8
Dependent Claim
61 words
A process according to claim 1 in which: said glucose is epimerized in an acidic solution, (a) said mixture of glucose and mannose in aqueous solution is passed through a column of whole Arthrobacter cells containing said glucose isomerase enzyme, and (b) said mixture of glucose, fructose, and mannose is hydrogenated under non-alkaline conditions in the presence of a nickel catalyst.
Claim 9
Dependent Claim
18 words
A process according to claim 7 in which said hexavalent molybdenum catalyst is dissolved in said acidic solution.
Claim 10
Dependent Claim
35 words
A process according to claim 7 in which said mixture of glucose and mannose is treated with an ion exchange resin prior to contact with said Arthrobacter cells in order to remove said molybdenum catalyst.
Claim 11
Dependent Claim
106 words
A process for obtaining a mixture of glucose, fructose, and mannose in aqueous solution which comprises: (a) catalytically epimerizing glucose in an acidic aqueous solution in the presence of a hexavalent molybdenum catalyst at a temperature not exceeding about 100° C., thereby obtaining a mixture of glucose and mannose in aqueous solution; and (b) contacting said mixture of glucose and mannose in aqueous solution with a glucose isomerase enzyme under enzymatic isomerization conditions, whereby a portion of the glucose content but no substantial portion of the mannose content of said mixture is isomerized and a mixture of glucose, fructose, and mannose in aqueous solution is formed.
Claim 12
Dependent Claim
106 words
A process for obtaining a mixture of glucose, fructose, and mannose in aqueous solution which comprises: (a) catalytically epimerizing glucose in an acidic aqueous solution in the presence of a hexavalent molybdenum catalyst at a temperature not exceeding about 100° C., thereby obtaining a mixture of glucose and mannose in aqueous solution; and (b) contacting said mixture of glucose and mannose in aqueous solution with a glucose isomerase enzyme under enzymatic isomerization conditions, whereby a portion of the glucose content but no substantial portion of the mannose content of said mixture is isomerized and a mixture of glucose, fructose, and mannose in aqueous solution is formed.
Claim 13
Dependent Claim
19 words
A process according to claim 10 in which said glucose is epimerized at a temperature of about 90°-100° C.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-11-05 | 1983-05-07 | 1983-11-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-11-05 | 1987-05-07 | 1987-11-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-11-05 | 1991-05-07 | 1991-11-06 | $7700.00 | Window Closed / Lapsed |