Patent US4152418A successfully refreshed from Google Patents.
US4152418A
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Zinc and enzyme mouthwash and mouthwash concentrate for reducing dental plaque and calculus formation
Assignee: Lever Brothers Co
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Filing: 1977-12-01
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Granted: 1979-05-01
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Expires: 1997-12-01
Abstract
Abstract There is disclosed in this specification an improved composition for reducing dental plaque and calculus formation, comprising zinc ions and an organoleptically acceptable enzyme, which may be a protease, carbohydrase, or lipase, or mixtures of these enzymes.
Inventors
- 👤 Morton Pader
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 20:56
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61K8/66; A61K8/19; A61K8/27; A61Q; A61Q11/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
120 words
A fluoride-free mouthwash capable or reducing dental plaque and calculus consisting essentially of: (a) about 0.01% to about 5% of a non-enzyme bound, pharmaceutically acceptable zinc compound selected from the group consisting of zinc acetate, benzoate, borate, carbonate, citrate, dl-lactate trihydrate, phenolsulfonate, silicate, an alkanoate having 8 to 18 carbon atoms, salicylate, stannate, sulfate, tannate and titanate; (b) about 0.0001% to about 5% of an enzyme preparation selected from the group consisting of a protease, a carbohydrase, a lipase and mixtures thereof; (c) 0 to about 50% of a non-aqueous liquid selected from the group consisting of ethyl alcohol, propylene glycol, 1,3-butylene glycol and mixtures threof; (d) 0 to 2% of surfactants and suspending agents; and (e) the balance water.
Claim 2
Dependent Claim
120 words
A fluoride-free mouthwash capable or reducing dental plaque and calculus consisting essentially of: (a) about 0.01% to about 5% of a non-enzyme bound, pharmaceutically acceptable zinc compound selected from the group consisting of zinc acetate, benzoate, borate, carbonate, citrate, dl-lactate trihydrate, phenolsulfonate, silicate, an alkanoate having 8 to 18 carbon atoms, salicylate, stannate, sulfate, tannate and titanate; (b) about 0.0001% to about 5% of an enzyme preparation selected from the group consisting of a protease, a carbohydrase, a lipase and mixtures thereof; (c) 0 to about 50% of a non-aqueous liquid selected from the group consisting of ethyl alcohol, propylene glycol, 1,3-butylene glycol and mixtures threof; (d) 0 to 2% of surfactants and suspending agents; and (e) the balance water.
Claim 3
Dependent Claim
12 words
The mouthwash of claim 1 wherein said zinc salt is zinc phenolsulfonate.
Claim 4
Dependent Claim
12 words
The mouthwash of claim 1 wherein said zinc .salt is zinc citrate.
Claim 5
Dependent Claim
12 words
The mouthwash of claim 1 wherein said non-aqueous liquid is ethyl alcohol.
Claim 6
Dependent Claim
16 words
The mouthwash of claim 1 wherein said enzyme preparation is a protease derived from Bacillus subtilis.
Claim 7
Dependent Claim
16 words
The mouthwash of claim 1 wherein said enzyme preparation is a lipase derived from animal pancreas.
Claim 8
Dependent Claim
12 words
The mouthwash of claim 1 wherein said enzyme preparation is an amylase.
Claim 9
Dependent Claim
103 words
A substantially water-free and fluoride-free fluid suspension for use as a mouthwash concentrate comprising: (a) about 0.01% to about 15% zinc ions furnished by a non-enzyme bound, pharmaceutically acceptable zinc compound selected from the group consisting of zinc acetate, benzoate, borate, carbonate, citrate, dl-lactate trihydrate, phenolsulfonate, silicate, an alkanoate having 8 to 18 carbon atoms, salicylate, stannate, sulfate, tannate and titanate; (b) about 0.01% to about 30% of a cosmetically acceptable enzyme preparation selected from the group consisting of protease, a carbohydrase, a lipase and mixtures thereof; and (c) a non-aqueous liquid base selected from the group consisting of glycerol and ethyl alcohol.
Claim 10
Dependent Claim
103 words
A substantially water-free and fluoride-free fluid suspension for use as a mouthwash concentrate comprising: (a) about 0.01% to about 15% zinc ions furnished by a non-enzyme bound, pharmaceutically acceptable zinc compound selected from the group consisting of zinc acetate, benzoate, borate, carbonate, citrate, dl-lactate trihydrate, phenolsulfonate, silicate, an alkanoate having 8 to 18 carbon atoms, salicylate, stannate, sulfate, tannate and titanate; (b) about 0.01% to about 30% of a cosmetically acceptable enzyme preparation selected from the group consisting of protease, a carbohydrase, a lipase and mixtures thereof; and (c) a non-aqueous liquid base selected from the group consisting of glycerol and ethyl alcohol.
Claim 11
Dependent Claim
12 words
The fluid suspension of claim 8 wherein said liquid base is glycerol.
Claim 12
Dependent Claim
15 words
The fluid suspension as in claim 8 wherein said zinc compound is zinc phenol sulfonate.
Claim 13
Dependent Claim
17 words
The fluid suspension of claim 8 wherein said enzyme preparation is a protease derived from Bacillus subtilis.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-30 | 1982-10-30 | 1983-05-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-30 | 1986-10-30 | 1987-05-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-30 | 1990-10-30 | 1991-05-01 | $7700.00 | Window Closed / Lapsed |