Patent US4094984A successfully refreshed from Google Patents.
US4094984A
Expired / Lapsed
US
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6-Phenyl-8-bromo-4H-s-triazolo-[3,4C]-thieno-[2,3E]-1,4-diazepines and salts thereof
Assignee: Boehringer Ingelheim GmbH
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Filing: 1977-10-06
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Granted: 1978-06-13
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Expires: 1997-10-06
Abstract
Abstract Compounds of the formula <IMAGE> wherein R1 is hydrogen, chlorine, bromine or alkyl of 1 to 4 carbon atoms; R2 is hydrogen, fluorine, chlorine, bromine, nitro or trifluoromethyl; and R3 is chlorine, bromine, alkoxy of 1 to 3 carbon atoms, alkylmercapto of 1 to 3 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloalkenyl of 3 to 6 carbon atoms, or a saturated or unsaturated 5- to 6-membered heterocycle comprising an oxygen, sulfur or nitrogen heteroatom, where a substitutable nitrogen heteroatom may optionally have a lower akyl substituent attached thereto; and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as tranquilizers, muscle-relaxants and anticonvulsants.
Inventors
- 👤 Karl-Heinz Weber
- 👤 Adolf Bauer
- 👤 Peter Danneberg
- 👤 Franz Josef Kuhn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:59
CPC Classifications
C; C07; C07D; C07D495/00; C07D495/02; C07D495/04; A; A61; A61P; A61P25/00; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/30; C07D333/36; C07D495/12; C07D495/14
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
46 words
A compound of the formula ##STR17## wherein R 1 is hydrogen, fluorine, chlorine, bromine, nitro or trifluoromethyl; and R 2 is hydrogen, alkyl of 1 to 4 carbon atoms or hydroalkyl of 1 to 4 carbon atoms; or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
46 words
A compound of the formula ##STR17## wherein R 1 is hydrogen, fluorine, chlorine, bromine, nitro or trifluoromethyl; and R 2 is hydrogen, alkyl of 1 to 4 carbon atoms or hydroalkyl of 1 to 4 carbon atoms; or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
26 words
A compound of claim 1, where R 1 is chlorine or bromine, and R 2 is methyl or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
17 words
A compound of claim 2, which is 8-bromo-6-(o-chloro-phenyl)-1-methyl-4H-s-triazolo-[3,4c]-thieno-[2,3e]-1,4-diazepine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
17 words
A compound of claim 2, which is 8-bromo-6-(o-bromo-phenyl)-1-methyl-4H-s-triazolo-[3,4c]-thieno-[2,33]-1,4-diazepine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
17 words
A compound of claim 2, which is 8-bromo-6-(o-fluoro-phenyl)-1-methyl-4H-s-triazolo-[3,4c]-thieno-[2,33]-1,4-diazepine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
17 words
A compound of claim 2, which is 8-bromo-6-(o-chloro-phenyl)-1-hydroxyethyl-4H-s-triazolo-[3,4c]-thieno[2,3e]-1,4-diazepine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
27 words
A pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective anxiolytic, tension-relieving, muscle-relaxing or anticonvulsive amount of a compound of claim 1.
Claim 9
Dependent Claim
42 words
The method of relieving anxiety, relieving tension, relaxing the muscles or suppressing convulsions in a warm-blooded animal, which comprises perorally, parenterally or rectally administering to said animal an effective anxiolytic, tension-relieving, muscle relaxing or anticonvulsive amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-12 | 1981-12-12 | 1982-06-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-12 | 1985-12-12 | 1986-06-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-12 | 1989-12-12 | 1990-06-13 | $7700.00 | Window Closed / Lapsed |