6-phenyl-s-triazolo{8 4,3-a{9 {8 1,4{9 {0 benzodiazepines

Abstract

Abstract This invention relates to novel 6-phenyl-s-triazolo (4,3-a) (1,4)benzodiazepines embraced by the formulas WHEREIN R is selected from the group consisting of hydrogen, lower alkyl of one through three carbon atoms, phenyl, benzyl, nitromethyl, cyanomethyl, lower alkoxymethyl having an alkoxy moiety of one through three carbon atoms IN WHICH N IS AN INTEGER OF 1 THROUGH 2, R'' and R'''' are each selected from the group consisting of hydrogen and alkyl of one through three carbon atoms and when combined is an alkylidene bridge of four through five carbon atoms; R1 is selected from the group consisting of hydroxy and lower acyloxy; R2, R3, R4 and R5 are selected from the group consisting of hydrogen, lower alkyl of one through three carbon atoms, halogen, nitro, cyano, trifluoromethyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, amino, lower alkanoylamino and lower dialkylamino; and a pharmacologically acceptable acid addition sat thereof. It also relates to novel processes for the preparation of the aforesaid compounds. The new products of Formulas I, II, III and IV are useful as sedatives, hypnotics, tranquilizers, muscle relaxants and anticonvulsants. Also, as feed additives for increasing growth rate and feed efficiency of livestock.

Inventors

• 👤 Jackson B Hester Jr

Bibliographic Details