Tetrahydrobenzothienodiazepinone compounds
Abstract
Abstract AND SALTS THEREOF; WHERE R1 IS HYDROGEN OR METHYL, AND AR IS PHENYL, O-FLUOROPHENYL, O-CHLOROPHENYL, OR 2-TRIENYL; AND THEIR PRODUCTION BY (A) REACTING A 3-AROYL-2-(2-HALOACETAMIDO)TETRAHYDROBENZOTHIOPHENE OR A SALT THEREOF WITH AMMONIA, (B) REACTING A 3-AROYL-2-(2-PHTHALIMIDOACETAMIDO)TETRAHYDROBENZOTHIOPHENE WITH ANHYDROUS HYDRAZINE, (C) REACTING A 2-(2-AMINOACETAMIDO)-3-AROYLTETRAHYDROBENZOTHIOPHENE SALT WITH A BASE, AND (D) REACTING ONE OF THE TETRAHYDROBENZOTHIENODIAZEPINONE COMPOUNDS WHEREIN R1 IS HYDROGEN WITH A METHHLATING AGENT IN THE PRESENCE OF A BASE. THE COMPOUNDS OF THE INVENTION ARE USEFUL AS ANTICONVULSANT AND ANTI-ANXIETY AGENTS. 1,4-DIAZEPIN-2-ONE 1-R1,5-AR-2,3,6,7,8,9-HEXAHYDRO-1H-1-BENZOTHIENO(2,3-E)- TETRAHYDROBENZOTHIENODIAZEPINONE COMPOUNDS HAVING THE FORMULA
Inventors
- 👤 Francis J Tinney
Bibliographic Details
Claims Analysis
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