US4091091A — Stabilized nitroglycerin tablets

Claim 1

Independent Claim 94 words

A sublingual pharmaceutical composition consisting essentially of nitroglycerin, polyvinylpyrrolidone and at least one conventional pharmacologically inert, non-toxic, water-soluble sublingual pharmaceutical excipient chemically compatible with nitroglycerin, said sublingual pharmaceutical composition having a stabilized nitroglycerin content as compared to sublinqual pharmaceutical compositions prepared only from nitroglycerin and at least one of said conventional sublingual pharmaceutical excipients, or a combination of said excipients, and wherein nitroglycerin is the sole pharmacologically active agent, and polyvinylpyrrolidone is the sole stabilizer therefor, and wherein the nitroglycerin is admixed with the polyvinylpyrrolidone in a weight ratio of about 10:1 to 1:4.

Claim 2

Dependent Claim 94 words

A sublingual pharmaceutical composition consisting essentially of nitroglycerin, polyvinylpyrrolidone and at least one conventional pharmacologically inert, non-toxic, water-soluble sublingual pharmaceutical excipient chemically compatible with nitroglycerin, said sublingual pharmaceutical composition having a stabilized nitroglycerin content as compared to sublinqual pharmaceutical compositions prepared only from nitroglycerin and at least one of said conventional sublingual pharmaceutical excipients, or a combination of said excipients, and wherein nitroglycerin is the sole pharmacologically active agent, and polyvinylpyrrolidone is the sole stabilizer therefor, and wherein the nitroglycerin is admixed with the polyvinylpyrrolidone in a weight ratio of about 10:1 to 1:4.

Claim 3

Dependent Claim 53 words

A stabilized pharmaceutical tablet containing nitroglycerin comprising from about 0.5 to about 5 percent of nitroglycerin, from about 0.5 to about 2 percent polyvinylpyrrolidone, and from about 93 to about 99 percent of an excipient or excipients selected from the group consisting of lactose, beta-lactose, milk sugar, fructose, maltose, sucrose, mannitol, and sorbitol.

Claim 4

Dependent Claim 53 words

A stabilized pharmaceutical tablet containing nitroglycerin comprising from about 0.5 to about 5 percent of nitroglycerin, from about 0.5 to about 2 percent polyvinylpyrrolidone, and from about 93 to about 99 percent of an excipient or excipients selected from the group consisting of lactose, beta-lactose, milk sugar, fructose, maltose, sucrose, mannitol, and sorbitol.

Claim 5

Dependent Claim 29 words

The pharmaceutical tablet of claim 1 wherein said tablet is comprised of about 0.5 percent nitroglycerin, about 1 percent polyvinylpyrrolidone, about 4.5 percent beta-lactose and about 94 percent lactose.

Claim 6

Dependent Claim 29 words

The pharmaceutical tablet of claim 1 wherein said tablet is comprised of about 1 percent nitroglycerin, about 1 percent polyvinylpyrrolidone, about 9 percent beta-lactose and about 89 percent lactose.

Claim 7

Dependent Claim 29 words

The pharmaceutical tablet of claim 1 wherein said tablet is comprised of about 1.25 percent nitroglycerin, about 1 percent polyvinylpyrrolidone, about 11.25 percent beta-lactose and about 86.5 percent lactose.

Claim 8

Dependent Claim 29 words

The pharmaceutical tablet of claim 1 wherein said tablet is comprised of about 2 percent nitroglycerin, and 1 percent polyvinylpyrrolidone, about 18 percent beta-lactose, and about 79 percent lactose.

Claim 9

Independent Claim 108 words

The method of stabilizing a pharmaceutical tablet of nitroglycerin against the migration of nitroglycerin between such tablets when in contact with each other comprising combining an alcohol-water dispersion of polyvinylpyrrolidone with a nitroglycerin tablet trituration comprised of nitroglycerin and an excipient or excipients selected from the group consisting of beta-lactose, lactose, milk sugar, sucrose, fructose, maltose, mannitol and sorbitol prior to the forming of said tablet, said dispersion being combined with said trituration in an amount to provide for a polyvinylpyrrolidone content of from about 0.5 to about 2.0 percent of the final dry tablet weight, and removing the alcohol-water from the tablets after the latter are formed.

Claim 10

Independent Claim 108 words

The method of stabilizing a pharmaceutical tablet of nitroglycerin against the migration of nitroglycerin between such tablets when in contact with each other comprising combining an alcohol-water dispersion of polyvinylpyrrolidone with a nitroglycerin tablet trituration comprised of nitroglycerin and an excipient or excipients selected from the group consisting of beta-lactose, lactose, milk sugar, sucrose, fructose, maltose, mannitol and sorbitol prior to the forming of said tablet, said dispersion being combined with said trituration in an amount to provide for a polyvinylpyrrolidone content of from about 0.5 to about 2.0 percent of the final dry tablet weight, and removing the alcohol-water from the tablets after the latter are formed.

Claim 11

Dependent Claim 30 words

The method of claim 7 wherein the polyvinylpyrrolidone is dispersed in an approximately 2:1 alcohol-water solution in a ratio of about 1 part polyvinylpyrrolidone to about 10 parts alcohol-water solution.

Claim 12

Dependent Claim 31 words

The method of claim 8 wherein the polyvinylpyrrolidone is admixed with the nitroglycerin trituration in an amount that will represent about 1 percent of the final dry weight of the tablets.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1981-05-22	1981-11-21	1982-05-23	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1985-05-22	1985-11-21	1986-05-23	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1989-05-22	1989-11-21	1990-05-23	$7700.00	Window Closed / Lapsed

Stabilized nitroglycerin tablets

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