US3873727A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stabilization of molded sublingual nitroglycerin tablets
Assignee: Parke Davis and Co LLC
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Filing: 1973-11-08
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Granted: 1975-03-25
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Expires: 1993-11-08
Abstract
Abstract Methods for preparing nitroglycerin containing pharmaceutical compositions in the form of tablets suitable for sublingual administration, are disclosed, which comprises wetting a substantially dry mixture of the nitroglycerin and a solid, water-soluble pharmaceutical carrier with a solvent mixture containing a non-volatile, water-soluble solvent and a volatile solvent, forming the wetted mixture into tablets, and removing the volatile solvent.
Inventors
- 👤 Salvatore A Fusari
- 👤 Leslie M Lueck
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 02:27
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/04; A61K9/00; A61K9/20; A61K9/2004; A61K9/2013; A61K9/2018
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
147 words
IN A PROCESS FOR THE PRODUCTION OF MOLDED TABLETS CAPABLE OF GIVING A RAPID RELEASE OF NITROGLYCERIN UPON SUBLINGUAL ADMINISTRATION, WHEREIN THE IMPROVEMENT IN STABILITY IS THE RETAINING OF THE ORIGINAL POTENCY IN EACH TABLET DURING STORAGE IN SEALED CONTAINERS CONTAINING A PLURALITY OF SUCH TABLETS AND CONTAINER STUFFING CAPABLE OF ABSORBING NITROGLYCERIN, CONSISTING OF THE STEPS A. PREPARING A SUBSTANTIALLY DRY MIXTURE OF ONE PART BY WEIGHT OF NITROGLYCERIN AND 20 TO 200 PARTS BY WEIGHT OF A SOLID, WATER-SOLUBLE PHARMACEUTICAL CARRIER OF THE CLASS CONSISTING OF LACTOSE, GLUCOSE, SUCROSE, MANNITOL AND SORBITOL B. WETTING THAT SUBSTANTIALLY DRY MIXTURE WITH A SOLVENT MIXTURE CONTAINING 0.5 TO 0.9 PARTS BY WEIGHT OF A NONVOLATILE, WATER-SOLUBLE SOLVENT AND A SUFFICIENT QUANTITY OF A VOLATILE SOLVENT SELECTED FROM THE GROUP CONSISTING OF POLYETHYLENE GLYCOLS HAVING AN AVERAGE MOLECULAR WEIGHT OF FROM 300 TO 7,500, TETRAMETHYLENE GLYCOL, AND PENTAMETHYLENE GLYCOL.
Claim 2
Dependent Claim
147 words
IN A PROCESS FOR THE PRODUCTION OF MOLDED TABLETS CAPABLE OF GIVING A RAPID RELEASE OF NITROGLYCERIN UPON SUBLINGUAL ADMINISTRATION, WHEREIN THE IMPROVEMENT IN STABILITY IS THE RETAINING OF THE ORIGINAL POTENCY IN EACH TABLET DURING STORAGE IN SEALED CONTAINERS CONTAINING A PLURALITY OF SUCH TABLETS AND CONTAINER STUFFING CAPABLE OF ABSORBING NITROGLYCERIN, CONSISTING OF THE STEPS A. PREPARING A SUBSTANTIALLY DRY MIXTURE OF ONE PART BY WEIGHT OF NITROGLYCERIN AND 20 TO 200 PARTS BY WEIGHT OF A SOLID, WATER-SOLUBLE PHARMACEUTICAL CARRIER OF THE CLASS CONSISTING OF LACTOSE, GLUCOSE, SUCROSE, MANNITOL AND SORBITOL B. WETTING THAT SUBSTANTIALLY DRY MIXTURE WITH A SOLVENT MIXTURE CONTAINING 0.5 TO 0.9 PARTS BY WEIGHT OF A NONVOLATILE, WATER-SOLUBLE SOLVENT AND A SUFFICIENT QUANTITY OF A VOLATILE SOLVENT SELECTED FROM THE GROUP CONSISTING OF POLYETHYLENE GLYCOLS HAVING AN AVERAGE MOLECULAR WEIGHT OF FROM 300 TO 7,500, TETRAMETHYLENE GLYCOL, AND PENTAMETHYLENE GLYCOL.
Claim 3
Dependent Claim
19 words
Process of claim 1 wherein the solid, water soluble pharmaceutical carrier is substantially a mixture of lactose and sucrose.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-24 | 1978-09-23 | 1979-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-24 | 1982-09-23 | 1983-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-24 | 1986-09-23 | 1987-03-25 | $7700.00 | Window Closed / Lapsed |