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US4089872A
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Antibiotics steffimycinol and 7-deoxysteffimycinol and process for preparing the same
Assignee: Pharmacia and Upjohn Co
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Filing: 1977-03-09
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Granted: 1978-05-16
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Expires: 1997-03-09
Abstract
Abstract Antibiotics steffimycinol and 7-deoxysteffimycinol produced by reduction of the antibiotic steffimycinone. Steffimycinol is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Streptococcus pyogenes; 7-deoxysteffimycinol is active against Sarcina lutea, Bacillus cereus, and B. subtilis. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.
Inventors
- 👤 James M. Koert
- 👤 Paul F. Wiley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 10:53
CPC Classifications
C; C07; C07C; C07C46/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
16 words
Steffimycinol, a compound having the following structure: ##STR3## and alkali and alkaline earth metal salts thereof.
Claim 2
Dependent Claim
16 words
Steffimycinol, a compound having the following structure: ##STR3## and alkali and alkaline earth metal salts thereof.
Claim 3
Dependent Claim
16 words
7-Deoxysteffimycinol, a compound having the following structure: ##STR4## and alkali and alkaline earth metal salts thereof.
Claim 4
Dependent Claim
16 words
7-Deoxysteffimycinol, a compound having the following structure: ##STR4## and alkali and alkaline earth metal salts thereof.
Claim 5
Dependent Claim
48 words
Tetra-O-acylates of the compound defined in claim 1 wherein said acyl group consists of a hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive; halo-, nitro-, hydroxy-, amino-, cyano-, thiocyano-, and lower alkoxy-substituted hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive.
Claim 6
Dependent Claim
48 words
Tri-O-acylates of the compound defined in claim 2 wherein said acyl group consists of a hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive; halo-, nitro-, hydroxy-, amino-, cyano-, thiocyano-, and lower alkoxy-substituted hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive.
Claim 7
Dependent Claim
26 words
A process for preparing the compound of claim 1 which comprises reduction of steffimycinone with one mole or less of a metal hydride or aluminum isopropoxide.
Claim 8
Dependent Claim
13 words
A process, according to claim 5, wherein NaBH 4 is the metal hydride.
Claim 9
Dependent Claim
21 words
A process, according to claim 5, wherein one mole or less of the metal hydride is used per mole of steffimycinone.
Claim 10
Dependent Claim
25 words
A process for preparing the compound of claim 2 which comprises reduction of steffimycinone with a large excess of a metal hydride or aluminum isopropoxide.
Claim 11
Dependent Claim
13 words
A process, according to claim 8, wherein NaBH 4 is the metal hydride.
Claim 12
Dependent Claim
20 words
A process, according to claim 8, wherein about 5 moles of the metal hydride is used per mole of steffimycinone.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-15 | 1981-11-14 | 1982-05-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-15 | 1985-11-14 | 1986-05-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-15 | 1989-11-14 | 1990-05-16 | $7700.00 | Window Closed / Lapsed |