Naphthacene derivatives
Abstract
Abstract New derivatives of 4-methoxy-5,12-dioxo-6,9,11-trihydroxy-9acetyl-5,7,8,9,10,12 -hexahydronaphthacene with a substituent -OCO-R in the 7-position, wherein R represents cyclohexyl substituted by an aminomethyl group, or by at least one amino group, monoalkylamino group of which the alkyl radical contains one to five carbon atoms, dialkylamino group of which each alkyl radical contains one to five carbon atoms, or sulphomethylamino group, or R represents a said substituted-cyclohexyl group also substituted by at least one hydroxy group or alkanoyloxy group of which the alkanoyl radical contains one to five carbon atoms, or R represents a phenylalkyl group of which the alkyl radical contains one to four carbon atoms and is substituted by a bis(2chlorethyl)amino group, or a piperidyl group, and non-toxic salts thereof, have useful properties against leukaemia L1210 in mice, combined with a low toxicity.
Inventors
- 👤 Georges Jolles
Bibliographic Details
Claims Analysis
Total Claims: 10References Cited (Backward Citations)
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