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US4072668A
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LH-RH Analogs
Assignee: Salk Institute for Biological Studies
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Filing: 1974-09-27
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Granted: 1978-02-07
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Expires: 1994-09-27
Abstract
Abstract Peptides have been synthesized which influence the secretion of gonadotropins by the pituitary gland of mammalians, including humans. Some of the peptides promote the release of gonadotropins, while other peptides inhibit the release.
Inventors
- 👤 Max S. Amoss
- 👤 Michael W. Monahan
- 👤 Wylie W. Vale, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 09:11
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/23; C07K7/16; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
41 words
A peptide which influences the release of gonadotropins by the pituitary gland, said peptide being pGlu-R 1 -Trp-Ser-Tyr-R 2 -Leu-Arg-Pro-Gly-NH 2 wherein R 1 is either deleted or selected from His, Gly, Asp, Cys and D-Ala and R 2 is D-Ala.
Claim 2
Dependent Claim
41 words
A peptide which influences the release of gonadotropins by the pituitary gland, said peptide being pGlu-R 1 -Trp-Ser-Tyr-R 2 -Leu-Arg-Pro-Gly-NH 2 wherein R 1 is either deleted or selected from His, Gly, Asp, Cys and D-Ala and R 2 is D-Ala.
Claim 3
Dependent Claim
17 words
A peptide in accordance with claim 1 wherein R 1 is His and R 2 is D-Ala.
Claim 4
Dependent Claim
17 words
A peptide in accordance with claim 1 wherein R 1 is deleted and R 2 is D-Ala.
Claim 5
Dependent Claim
17 words
A peptide in accordance with claim 1 wherein R 1 is Gly and R 2 is D-Ala.
Claim 6
Dependent Claim
45 words
A peptide which influences the release of gonadotropins by the pituitary gland, said peptide being pGlu-R 1 -Trp-Ser-Tyr-R 2 -Leu-Arg-Pro-NHCH 2 CH 2 CH 3 wherein R 1 is either deleted or selected from His, Gly, Asp, Cys, and D-Ala and R 2 is D-Ala.
Claim 7
Dependent Claim
45 words
A peptide which influences the release of gonadotropins by the pituitary gland, said peptide being pGlu-R 1 -Trp-Ser-Tyr-R 2 -Leu-Arg-Pro-NHCH 2 CH 2 CH 3 wherein R 1 is either deleted or selected from His, Gly, Asp, Cys, and D-Ala and R 2 is D-Ala.
Claim 8
Dependent Claim
17 words
A peptide in accordance with claim 5 wherein R 1 is His and R 2 is D-Ala.
Claim 9
Dependent Claim
17 words
A peptide in accordance with claim 1 wherein R 1 is Gly and R 2 is D-Ala.
References Cited (Backward Citations)
US3853834A
Cited
US3896104A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-02-06 | 1981-08-08 | 1982-02-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-02-06 | 1985-08-08 | 1986-02-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-02-06 | 1989-08-08 | 1990-02-07 | $7700.00 | Window Closed / Lapsed |