US3853834A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4-alanine lh-rh analog
Assignee: Eli Lilly and Co
•
Filing: 1972-10-19
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Granted: 1974-12-10
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Expires: 1992-10-19
Abstract
Abstract An analog of LH-RH having the formula PyroGlu-His-Trp-Ala-TyrGly-Leu-Arg-Pro-Gly-NH2 as well as its pharmaceutically acceptable acid addition salts exhibit luteinizing hormone release activity and are useful in stimulating fertility in humans and synchronizing estrous in farm animals.
Inventors
- 👤 J Shields
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 18:26
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; C07K5/08; C07K5/0802; C07K5/0804; C07K5/0806; C07K7/00; C07K7/04; C07K7/23; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 2
Dependent Claim
5 words
A COMPOUND OF THE FORMULA
Claim 3
Dependent Claim
18 words
Compound of claim 1, in which R is ethyl, R2 is t-butyl, and R1 is H- or CBz-.
Claim 4
Dependent Claim
18 words
Compound of claim 1, in which R is p-nitrobenzyl, R2 is benzyl, and R1 is H- or BOC-.
Claim 5
Dependent Claim
62 words
A compound of the formula R1-L-Trp-L-Ala-L-Tyr(R2)-Gly(R) in which R is hydrogen, methyl, ethyl, p-nitrobenzyl, or benzyl; R2 is t-butyl, benzyl, or 2,6-dichlorobenzyl; and, when R2 is t-butyl, R1 is H-, Cbz-, or (AdOC)2-L-His-; and, when R2 is benzyl or 2,6-dichlorobenzyl, R1 is H-, CBz-, AdOC-, BOC-, AOC-, or (AdOC)2-L-His-; or an acid addition salt of those compounds in which R1 is H-.
Claim 6
Dependent Claim
62 words
A compound of the formula R1-L-Trp-L-Ala-L-Tyr(R2)-Gly(R) in which R is hydrogen, methyl, ethyl, p-nitrobenzyl, or benzyl; R2 is t-butyl, benzyl, or 2,6-dichlorobenzyl; and, when R2 is t-butyl, R1 is H-, Cbz-, or (AdOC)2-L-His-; and, when R2 is benzyl or 2,6-dichlorobenzyl, R1 is H-, CBz-, AdOC-, BOC-, AOC-, or (AdOC)2-L-His-; or an acid addition salt of those compounds in which R1 is H-.
Claim 7
Dependent Claim
21 words
Compound of claim 4, in which R is hydrogen or ethyl, R2 is t-butyl, and R1 is H-, CBz-, or (AdOC)2-L-His-.
Claim 8
Dependent Claim
18 words
Compound of claim 4, in which R is hydrogen or p-nitrobenzyl, R2 is benzyl, and R1 is BOC-.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-09 | 1978-06-10 | 1978-12-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-09 | 1982-06-10 | 1982-12-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-09 | 1986-06-10 | 1986-12-10 | $7700.00 | Window Closed / Lapsed |