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Method for the early diagnosis of cancer

Assignee: Nauchno-Proizvodstveno Obedinenie Po Veterinarno Delo
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Filing: 1976-05-03
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Granted: 1977-12-20
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Expires: 1996-05-03
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Abstract

Abstract A method of detecting cancer in humans in which a blood sample is processed to recover the plasma from cellular matter and is then treated with aluminum oxide adsorbent and diluted. The diluted sample is subjected to spectrophotometric analysis at wavelengths of 562, 576 and 610 nm before and after dilution. The decrease in the extinction value A of the measurement at 576 mn, the difference B between the extinction values at 562 and 610 nm of the diluted sample and the value C constituting the difference between the changes in extinction values at 576 to 562 nm in the two measurements is determined and a coefficient is obtained where K = (A × B/C). A value K of less than 95 is indicative of a statistically significant possibility of cancer while a value above 105 has a statistically significant probability of lack of neoplasm.

Inventors

  • 👤 Vassil Ivanov Vassilev
  • 👤 Hristo Vladimirov Goranov
  • 👤 Sivcho Hristov Sivchev

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-04 16:00
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 245 words
A method of detecting cancer in humans which comprises the steps of: a. obtaining a blood sample from a patient to be screened for cancer; b. separating cellular matter from the blood plasma of said sample; c. treating said blood plasma with Brockmann aluminum oxide; d. subjecting a portion of the plasma treated with Brockmann aluminum oxide to spectrophotometric analysis at wavelengths of 562, 576 and 610 nm to obtain first extinction values at each of said wavelengths; e. diluting another portion of the plasma treated with Brockmann aluminum oxide to dilution with a standard diluent to produce a diluted specimen; f. subjecting said diluted specimen to spectrophotometric analysis at wavelengths of 562, 576 and 610 nm to obtain respective second values of total extinction at said wavelengths; g. deriving a value A corresponding to the percentage decrease in the first and second values at said wavelengths of 576 nm deriving a value B corresponding to the difference in the extinction of second values between the wavelengths of 562nm and 610 nm, and deriving a value C corresponding to the difference between the change in first extinction values at 576 nm to 562 nm and the change in said second values from 576 nm to 562 nm; and h. deriving a coefficient K = (A + B/C) where a K value less than 95 represents a statistically significant probability of cancer and a K value above 105 represents a statistically significant probability absence of cancer.
Claim 2
Independent Claim 245 words
A method of detecting cancer in humans which comprises the steps of: a. obtaining a blood sample from a patient to be screened for cancer; b. separating cellular matter from the blood plasma of said sample; c. treating said blood plasma with Brockmann aluminum oxide; d. subjecting a portion of the plasma treated with Brockmann aluminum oxide to spectrophotometric analysis at wavelengths of 562, 576 and 610 nm to obtain first extinction values at each of said wavelengths; e. diluting another portion of the plasma treated with Brockmann aluminum oxide to dilution with a standard diluent to produce a diluted specimen; f. subjecting said diluted specimen to spectrophotometric analysis at wavelengths of 562, 576 and 610 nm to obtain respective second values of total extinction at said wavelengths; g. deriving a value A corresponding to the percentage decrease in the first and second values at said wavelengths of 576 nm deriving a value B corresponding to the difference in the extinction of second values between the wavelengths of 562nm and 610 nm, and deriving a value C corresponding to the difference between the change in first extinction values at 576 nm to 562 nm and the change in said second values from 576 nm to 562 nm; and h. deriving a coefficient K = (A + B/C) where a K value less than 95 represents a statistically significant probability of cancer and a K value above 105 represents a statistically significant probability absence of cancer.
Claim 3
Dependent Claim 12 words
The method defined in claim 1 wherein said diluent is distilled water.
Claim 4
Dependent Claim 62 words
The method defined in claim 1 wherein the diluent used represents a natural liquid product having approximately the following composition: ______________________________________ mg/1 meq V % ______________________________________ ANIONS Fluorine 3.2 0.41 Chlorine 66.8 4.60 Sulphate 313.4 15.92 Bicarbonate 1977.1 79.07 CATIONS Sodium 576.8 61.20 Potassium 30.0 1.87 Calcium 297.1 27.89 Magnesium 45.0 9.04 Ac metasalicylicum 91.0 Ac metaboricum 5.2 pH = 6.10. ______________________________________

References Cited (Backward Citations)

US3327119A Cited
US3999944A Cited
US3988115A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-12-19 1981-06-20 1981-12-20 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-12-19 1985-06-20 1985-12-20 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-12-19 1989-06-20 1989-12-20 $7700.00 Window Closed / Lapsed

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