US3999944A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Detection of breast cancer
Assignee: Hoffmann La Roche Inc
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Filing: 1975-02-28
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Granted: 1976-12-28
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Expires: 1995-02-28
Abstract
Abstract The detection of breast cancer in humans by evaluating antigen induced leukocyte adherence inhibition caused by tumor specific cell mediated immunity by incubating a measured amount of a patients blood leukocytes with aqueous basic extracts of human breast tumor, then determining whether the leukocyte adherence inhibition measured by the non-adherence index as compared to a control of a non-specific antigen is high, indicating the presence of breast cancer, or low, indicating the absence of breast cancer.
Inventors
- 👤 Norman Grosser
- 👤 David Marshall Parks Thomson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:43
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/575; G01N33/57515
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
66 words
A method for detecting the presence of breast cancer in humans which comprises incubating a measured amount of a patient's blood leukocytes with aqueous basic extracts of human breast tumor, then determining the leukocyte non-adherence index by comparison to a non-specific antigen control, and concluding that breast cancer is present if the non-adherence index of the patient being tested is higher than the control non-adherence index.
Claim 2
Independent Claim
66 words
A method for detecting the presence of breast cancer in humans which comprises incubating a measured amount of a patient's blood leukocytes with aqueous basic extracts of human breast tumor, then determining the leukocyte non-adherence index by comparison to a non-specific antigen control, and concluding that breast cancer is present if the non-adherence index of the patient being tested is higher than the control non-adherence index.
Claim 3
Dependent Claim
20 words
The method of claim 1 wherein the breast tumor extract is from a breast tumor of the patient being tested.
Claim 4
Dependent Claim
21 words
The method of claim 2 wherein the breast tumor extract is from a breast tumor of a patient not being tested.
Claim 5
Dependent Claim
17 words
The process of claim 1 wherein the breast tumor extract is an aqueous extract at pH 7.3.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-12-28 | 1980-06-28 | 1980-12-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-12-28 | 1984-06-28 | 1984-12-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-12-28 | 1988-06-28 | 1988-12-28 | $7700.00 | Window Closed / Lapsed |