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US4036833A
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7-[(5'-N-methylthioacetamido)-adipoamido] cephalosporin derivatives
Assignee: Individual
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Filing: 1975-05-27
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Granted: 1977-07-19
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Expires: 1995-05-27
Abstract
Abstract New N-substituted thio (or sulfinyl) aliphatic acylcephalosporin C and their derivatives at the 3rd position have been prepared. The compounds are useful as intermediates for recovering cephalosporin C and deacetoxycephalosporin C from their fermentation broth and also for preparing 7-aminocephalosporanic acid and its derivatives at the 3rd position.
Inventors
- 👤 Toshiyasu Ishimaru
- 👤 Mariko Kawabata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 14:44
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/02; C07D501/12
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
51 words
A compound of the formula ##STR15## wherein R 1 is a lower alkyl, phenyl or benzyl group, R 2 is a lower alkylene group, Y is a sulfur atom or a sulfinyl group and R 3 is a thiadiazolyl, tetrazolyl or oxadiazolyl group; or a pharmaceutically acceptable salt or adduct thereof.
Claim 2
Dependent Claim
51 words
A compound of the formula ##STR15## wherein R 1 is a lower alkyl, phenyl or benzyl group, R 2 is a lower alkylene group, Y is a sulfur atom or a sulfinyl group and R 3 is a thiadiazolyl, tetrazolyl or oxadiazolyl group; or a pharmaceutically acceptable salt or adduct thereof.
Claim 3
Dependent Claim
14 words
The compound of claim 1, wherein R 3 is substituted by a methyl group.
Claim 4
Dependent Claim
7 words
7-[(5'-N-Methylthioacetamido)-adipoamido]-3-(1"-methyltetrazol-5"-yl)-thiomethyl-3-cephem-4-carboxylic acid in accordance with claim 1.
Claim 5
Dependent Claim
7 words
7-[(5-N-Methylthioacetamido)-adipoamido]-3-(5"-methyl-1",3",4"-thiadiazol-2"-yl)-thiomethyl-3-cephem-4-carboxylic acid in accordance with claim 1.
Claim 6
Dependent Claim
8 words
7-[(5'-N-Methylthioacetamido)-adipoamido]-3-(1',3', 4'-thiadiazol-2'-yl)-thiomethyl-3-cephem-4-carboxylic acid in accordance with claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-07-18 | 1981-01-17 | 1981-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-07-18 | 1985-01-17 | 1985-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-07-18 | 1989-01-17 | 1989-07-19 | $7700.00 | Window Closed / Lapsed |