Patent US4014651A successfully refreshed from Google Patents.
US4014651A
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Method for determining thyroid function and reagent composition therefor
Assignee: Takeda GmbH
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Filing: 1975-05-15
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Granted: 1977-03-29
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Expires: 1995-05-15
Abstract
Abstract A complete and self-contained in vitro diagnostic reagent composition for use in determining thyroid function comprises a buffered aqueous suspension of finely divided, amorphous silicon dioxide, having combined therewith a nonionic surfactant and a thyroid hormone substance tagged or labeled with radioisotopic iodine.
Inventors
- 👤 Ella M. Bettinger
- 👤 Everett K. Mincey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 21:01
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/74; G01N33/78; Y; Y10; Y10S; Y10S436/00; Y10S436/804; Y10S436/825; Y10S436/826
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
62 words
A diagnostic reagent composition for use in the in vitro determination of thyroid function comprising a buffered aqueous suspension containing: a. finely divided, amorphous silicon dioxide; b. a thyroid hormone substance tagged with radioactive iodine; and c. a nonionic surfactant; the weight to weight ratio of said amorphous silica to said nonionic surfactant being in the range of approximately 10:1 to 50:1.
Claim 2
Dependent Claim
62 words
A diagnostic reagent composition for use in the in vitro determination of thyroid function comprising a buffered aqueous suspension containing: a. finely divided, amorphous silicon dioxide; b. a thyroid hormone substance tagged with radioactive iodine; and c. a nonionic surfactant; the weight to weight ratio of said amorphous silica to said nonionic surfactant being in the range of approximately 10:1 to 50:1.
Claim 3
Dependent Claim
25 words
A diagnostic reagent composition as set forth in claim 1 wherein said thyroid hormone substance is selected from the group consisting of L-thyroxine and L-triiodothyronine.
Claim 4
Dependent Claim
36 words
A diagnostic reagent composition as set forth in claim 1 wherein said nonionic surfactant is selected from the group consisting of polyoxyethylene alcohols, polyoxyethylene sorbitan fatty acid esters, nonylphenoxypoly (ethyleneoxy) ethanols and sorbitan fatty acid esters.
Claim 5
Independent Claim
98 words
The method for the in vitro determination of thyroid function which comprises the steps of mixing a blood serum sample with a measured amount of a reagent composition comprising a buffered aqueous suspension containing a. finely divided amorphous silicon dioxide; b. a thyroid hormone substance tagged with radioactive iodine; and c. a nonionic surfactant; the weight to weight ratio of said amorphous silica to said nonionic surfactant being in the range of approximately 10:1 to 50:1; separating the silicon dioxide from the resulting suspension; and measuring the radioactivity of the separated silicon dioxide residue or the supernatant liquid.
Claim 6
Independent Claim
98 words
The method for the in vitro determination of thyroid function which comprises the steps of mixing a blood serum sample with a measured amount of a reagent composition comprising a buffered aqueous suspension containing a. finely divided amorphous silicon dioxide; b. a thyroid hormone substance tagged with radioactive iodine; and c. a nonionic surfactant; the weight to weight ratio of said amorphous silica to said nonionic surfactant being in the range of approximately 10:1 to 50:1; separating the silicon dioxide from the resulting suspension; and measuring the radioactivity of the separated silicon dioxide residue or the supernatant liquid.
Claim 7
Dependent Claim
23 words
The method as set forth in claim 4 wherein said thyroid hormone substance is selected from the group consisting of L-thyroxine and L-triiodothyronine.
Claim 8
Dependent Claim
34 words
The method as set forth in claim 4 wherein said nonionic surfactant is selected from the group consisting of polyoxyethylene alcohols, polyoxyethylene sorbitan fatty acid esters, nonylphenoxypoly (ethyleneoxy) ethanols and sorbitan fatty acid esters.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-03-28 | 1980-09-27 | 1981-03-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-03-28 | 1984-09-27 | 1985-03-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-03-28 | 1988-09-27 | 1989-03-29 | $7700.00 | Window Closed / Lapsed |