US4011222A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fluoro-substituted dibenzo[b,f]thiepins
Assignee: Hoffmann La Roche Inc
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Filing: 1976-01-12
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Granted: 1977-03-08
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Expires: 1996-01-12
Abstract
Abstract Compounds of the formulas ##STR1## wherein R, R 1 , R 2 , R 3 , R 4 and n are as hereinafter set forth, are described. The compounds of formulas I and Ia are prepared inter alia by the reaction of the corresponding dibenzo[b,f] thiepin and the corresponding piperazine compound. The end products are useful as neuroleptic agents.
Inventors
- 👤 Max Gerecke
- 👤 Jean-Pierre Kaplan
- 👤 Emilio Kyburz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 00:52
CPC Classifications
C; C07; C07D; C07D337/00; C07D337/02; C07D337/06; C07D337/10; C07D337/14; C07C; C07C323/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
105 words
A compound of the formula ##STR11## wherein n is an integer from 1 to 3; R is hydrogen or, when n is 2 or 3, is hydroxy or an alkanoyloxy group of 2-18 carbon atoms; one of R 1 and R 2 is hydrogen and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, fluoro, chloro or trifluoromethyl; and one of R 3 and R 4 is hydrogen, and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, fluoro, chloro or trifluoromethyl, provided that at least one of R 1 , R 2 , R 3 and R 4 is fluoro, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
105 words
A compound of the formula ##STR11## wherein n is an integer from 1 to 3; R is hydrogen or, when n is 2 or 3, is hydroxy or an alkanoyloxy group of 2-18 carbon atoms; one of R 1 and R 2 is hydrogen and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, fluoro, chloro or trifluoromethyl; and one of R 3 and R 4 is hydrogen, and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, fluoro, chloro or trifluoromethyl, provided that at least one of R 1 , R 2 , R 3 and R 4 is fluoro, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
15 words
A compound in accordance with claim 1, wherein R 3 or R 4 is fluoro.
Claim 4
Dependent Claim
17 words
A compound in accordance with claim 1, wherein R 3 is chloro and R 4 is fluoro.
Claim 5
Dependent Claim
28 words
A compound in accordance with claim 1, wherein R 1 or R 2 is methyl, methoxy, methylthio, dimethylsulfamoyl or trifluoromethyl, and R 3 or R 4 is fluoro.
Claim 6
Dependent Claim
19 words
A compound in accordance with claim 4, wherein the group --(CH 2 ) n --R is methyl or hydroxypropyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-03-07 | 1980-09-06 | 1981-03-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-03-07 | 1984-09-06 | 1985-03-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-03-07 | 1988-09-06 | 1989-03-08 | $7700.00 | Window Closed / Lapsed |