Dibenzo(b,f)thiepin-10-carboxylic acids
Abstract
Abstract A NEW PROCESS FOR THE PRODUCTION OF N-SUBSTITUTED DIBENZO(B,F)THIEPIN-10-METHYLAMINES AND CLOSELY RELATED COMPOUNDS IS PROVIDED, WHICH PROCESS CONSISTS ESSENTIALLY IN REDUCING CORRESPONDING AMIDES OF DIBENZO(B,F)THIEPIN10-CARBOXYLIC ACIDS WITH COMPLEX HYDRIDES. FURTHER ARE PROVIDED PROCESSES FOR THE PRODUCTION OF DIBENZO(B,F) THEIPIN-10-CARBOXYLIC ACIDS USED FOR THE PREPARATION OF SAID AMIDES. THE DIBENZO(B,F)THIEPIN-10-CARBOXYLIC ACIDS ARE NOVEL COMPOUNDS WHICH ALSO PROCESSES PHARMACOLOGICAL, PARTICULARLY ANTI-INFLAMMATORY PROPERTIES AND ARE ACTIVE INGREDIENTS FOR PHARMACEUTICAL COMPOSITIONS. A TYPICAL EMBODIMENT IS THE CONDENSATION OF O-(PHENYLTHIO)-BENZALDEHYDE WITH HIPPURIC ACID, WHICH LEADS WITH OR WITHOUT ISOLATION OF INTERMEDIATES TO DIBENZO(B,F)THIEPIN-10-CARBOXYLIC ACID, CONVERSION THEREOF INTO ITS CHLORIDE, REACTION OF THE LATTER WITH DIMETHYLAMINE AND REDUCTION OF THE DIMETHYLAMIDE OBTAINED WITH LITHIUM ALUMINIUM HYDRIDE IN THE PRESENCE OF AN ETHEREAL SOLVENT TO N,N-DIMETHYLDIBENZO(B,F)THIEPIN-10-METHYLAMINE.
Inventors
- 👤 J Gosteli
Bibliographic Details
Claims Analysis
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