US3966737A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fluoro-substituted dibenso[b,f] thiepins
Assignee: Hoffmann La Roche Inc
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Filing: 1974-05-17
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Granted: 1976-06-29
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Expires: 1994-05-17
Abstract
Abstract Compounds of the formulas WHEREIN R, R1, R2, R3, R4 and n are as hereinafter set forth, ARE DESCRIBED. The compounds of formulas I and Ia are prepared inter alia by the reaction of the corresponding dibenzo[b,f] thiepin and the corresponding piperazine compound. The end products are useful as neuroleptic agents.
Inventors
- 👤 Max Gerecke
- 👤 Jean-Pierre Kaplan
- 👤 Emilio Kyburz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 02:23
CPC Classifications
C; C07; C07D; C07D337/00; C07D337/02; C07D337/06; C07D337/10; C07D337/14; C07C; C07C323/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
105 words
A Compound of the formula ##SPC11## wherein n is an integer from 1 to 3; R is hydrogen or, when n is 2 or 3, is hydroxy or an alkanoyloxy group of 2-18 carbon atoms; one of R 1 and R 2 is hydrogen and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, fluoro, chloro or trifluoromethyl; and one of R 3 and R 4 is hydrogen, and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, fluoro, chloro or trifluoromethyl, provided that at least one of R 1 , R 2 , R 3 and R 4 is fluoro, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
105 words
A Compound of the formula ##SPC11## wherein n is an integer from 1 to 3; R is hydrogen or, when n is 2 or 3, is hydroxy or an alkanoyloxy group of 2-18 carbon atoms; one of R 1 and R 2 is hydrogen and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, fluoro, chloro or trifluoromethyl; and one of R 3 and R 4 is hydrogen, and the other is methyl, methoxy, methylthio, dimethylsulfamoyl, fluoro, chloro or trifluoromethyl, provided that at least one of R 1 , R 2 , R 3 and R 4 is fluoro, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
17 words
A compound in accordance with claim 1, wherein R 3 is chloro and R 4 is fluoro.
Claim 4
Dependent Claim
28 words
A compound in accordance with claim 1, wherein R 1 or R 2 is methyl, methoxy, methylthio, dimethylsulfamoyl or trifluoromethyl, and R 3 or R 4 is fluoro.
Claim 5
Dependent Claim
19 words
A compound in accordance with claim 3, wherein the group --(CH 2 ) n --R is methyl or hydroxypropyl.
Claim 6
Dependent Claim
8 words
A compound in accordance with claim 1, 1-(2-chloro-7-fluoro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methylpiperazine.
Claim 7
Dependent Claim
8 words
A compound in accordance with claim 1, 1-(3-chloro-8-fluoro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methylpiperazine.
Claim 8
Dependent Claim
8 words
A compound in accordance with claim 1, 4-(2-chloro-8-fluoro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-1-piperazinepropanol.
Claim 9
Dependent Claim
8 words
A compound in accordance with claim 1, 1-(8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]thiepin-10-yl)-4-methylpiperazine.
Claim 10
Dependent Claim
15 words
A compound in accordance with claim 1, wherein R 3 or R 4 is fluoro.
References Cited (Backward Citations)
GB1093910A
Cited
US3600391A
Cited
US3681354A
Cited
US3583989A
Cited
US3563993A
Cited
US3699104A
Cited
US3725409A
Cited
US3787444A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-29 | 1979-12-29 | 1980-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-29 | 1983-12-29 | 1984-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-29 | 1987-12-29 | 1988-06-29 | $7700.00 | Window Closed / Lapsed |