US20060025815A1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Lung device with sealing features
Assignee: Ekos LLC
•
Filing: 2005-07-08
•
Granted: —
•
Expires: 2025-07-08
Abstract
Abstract This invention relates generally to a design of lung devices for safely performing a transthoracic procedure. In particular, the invention provides devices and methods of using these devices to access the thoracic cavity with minimal risk of causing pneumothorax or hemothorax. More specifically, the invention enables diagnostic and therapeutic access to a thoracic cavity using large bore instruments. This invention also provides a method for diagnostic and therapeutic procedures using a device capable of sealing the wound upon withdrawal of the device. The invention includes a device comprising an elongated body adapted to make contact with a tissue of a subject through an access hole, and a sealant delivery element. The invention also includes a method of performing tissue treatment or diagnosis in a subject.
Inventors
- 👤 Erin McGurk
- 👤 Ronald Dieck
- 👤 Mark Mathis
- 👤 Charles Wartchow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:58
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/00491; A61B17/0057; A61B17/32; A61B17/320016; A61B17/32002; A61B17/34; A61B17/3415; A61B17/00234; A61B2017/00238; A61B2017/00278; A61B2017/00495; A61B2017/00637; A61B2017/00641; A61B2017/00743; A61B2017/00809
Claims Analysis
Total Claims: 69
Claim 1
Independent Claim
42 words
1 . A system comprising an elongated body adapted to provide access to target tissue of a subject through an access hole, a cross-linked tissue sealant, and a sealant delivery element adapted to deliver the cross-linked tissue sealant through the access hole.
Claim 2
Dependent Claim
42 words
1 . A system comprising an elongated body adapted to provide access to target tissue of a subject through an access hole, a cross-linked tissue sealant, and a sealant delivery element adapted to deliver the cross-linked tissue sealant through the access hole.
Claim 3
Dependent Claim
18 words
2 . The system of claim 1 wherein the system is adapted to deliver therapy to the subject.
Claim 4
Dependent Claim
18 words
3 . The system of claim 1 wherein the system is adapted to perform diagnostics on the subject.
Claim 5
Dependent Claim
30 words
4 . The system of claim 1 wherein the sealant delivery element is adapted to deliver sealant to the target tissue prior to performing a therapy on the target tissue.
Claim 6
Dependent Claim
27 words
5 . The system of claim 1 wherein the sealant delivery element is adapted to deliver a sealant to the access hole upon removal of the system.
Claim 7
Dependent Claim
29 words
6 . The system of claim 1 wherein the sealant delivery element is adapted to deliver a sealant to target tissue prior to performing diagnostics on the target tissue.
Claim 8
Dependent Claim
30 words
7 . The system of claim 1 , wherein the elongated body has a distal end and a proximal end, said distal end comprising a cutting element for excising tissue.
Claim 9
Dependent Claim
44 words
8 . The system of claim 7 , wherein the cutting element comprises an element selected from the group consisting of needle, grasper, forceps, scalpel, scraper, scissors, brush, ablation tools, RF loops, heaters, laser ablation, probes, mechanical excision devices, x-ray, radiation, and cryosurgical probes.
Claim 10
Dependent Claim
18 words
9 . The system of claim 1 , wherein the system is adapted for imaging the target tissue.
Claim 11
Dependent Claim
22 words
10 . The system of claim 1 , wherein the system is adapted to deliver a pharmaceutical composition to the target tissue.
Claim 12
Dependent Claim
19 words
11 . The system of claim 1 , further comprising a sleeve in which the elongated body is disposed.
Claim 13
Dependent Claim
16 words
12 . The system of claim 1 , wherein the cross-linked sealant accelerates a clotting cascade.
Claim 14
Dependent Claim
25 words
13 . The system of claim 1 , wherein the sealant comprises material selected from the group consisting of hydrogels, proteins, polymers and cross-linking agents.
Claim 15
Dependent Claim
29 words
14 . The system of claim 13 , wherein the hydrogel material comprises material selected from the group consisting of hyalurons, hyalyronic acid, alginates, chitins, chitosans, and derivatives thereof.
Claim 16
Dependent Claim
26 words
15 . The system of claim 13 , wherein the protein material comprises material selected from the group consisting of albumins, porcine albumins, collagens and gelatins.
Claim 17
Dependent Claim
24 words
16 . The system of claim 13 , wherein the polymer material comprises material selected from the group consisting of poly(lactic acid) and poly(glycolide).
Claim 18
Dependent Claim
25 words
17 . The system of claim 13 , wherein the cross-linking agent material comprises material selected from the group consisting of glutaraldehyde and stable polyaldehyde.
Claim 19
Dependent Claim
19 words
18 . The system of claim 1 wherein the cross-linked sealant has an adhesion force greater than 0.2 psi.
Claim 20
Dependent Claim
23 words
19 . The system of claim 1 , wherein the cross-linked sealant has an adhesion force of from 0.2 psi to 0.6 psi.
Claim 21
Dependent Claim
21 words
20 . The system of claim 1 wherein the cross-linked sealant has an adhesion force from 0.6 psi to 3.0 psi
Claim 22
Dependent Claim
18 words
21 . The system of claim 1 , wherein the cross-linked tissue sealant further comprises a detectable label.
Claim 23
Dependent Claim
22 words
22 . The system of claim 21 , wherein the detectable label is an enzyme, a radioactive isotope, or a luminescent substance.
Claim 24
Dependent Claim
19 words
23 . The system of claim 1 , wherein the cross-linked sealant has a viscosity greater than 1.1 centipoise.
Claim 25
Dependent Claim
56 words
24 . A lung device system comprising an elongated body adapted to make contact with an inner part of the lung or surrounding tissue of the lung through an access hole, a glutaraldehyde based sealant, and a hole closing element for closing the access hole adapted to deliver the glutaraldehyde based sealant through the access hole.
Claim 26
Dependent Claim
56 words
24 . A lung device system comprising an elongated body adapted to make contact with an inner part of the lung or surrounding tissue of the lung through an access hole, a glutaraldehyde based sealant, and a hole closing element for closing the access hole adapted to deliver the glutaraldehyde based sealant through the access hole.
Claim 27
Dependent Claim
16 words
25 . The lung device system of claim 24 wherein the glutaraldehyde based sealant is heat-treated.
Claim 28
Dependent Claim
32 words
26 . The lung device system of claim 24 , wherein the hole closing element is adapted to mitigate air or fluid leakage into a space between the lung and pleural membrane.
Claim 29
Dependent Claim
17 words
27 . The lung device system of claim 24 , wherein the hole closing element mitigates pneumothorax.
Claim 30
Dependent Claim
17 words
28 . The lung device system of claim 24 , wherein the hole closing element mitigates hemothorax.
Claim 31
Dependent Claim
18 words
29 . The lung device system of claim 24 , wherein the device is adapted for excising tissue.
Claim 32
Dependent Claim
19 words
30 . The lung device system of claim 24 , wherein the device is adapted for imaging bodily tissue.
Claim 33
Dependent Claim
20 words
31 . The lung device system of claim 24 , wherein the device delivers a pharmaceutical composition to the lung.
Claim 34
Dependent Claim
19 words
32 . The lung device system of claim 24 , wherein the sealant initiates or accelerates the clotting cascade.
Claim 35
Dependent Claim
29 words
33 . The lung device system of claim 24 , wherein the elongated body has a distal end and a proximal end, said distal end comprising a cutting element.
Claim 36
Dependent Claim
46 words
34 . The lung device system of claim 24 , wherein the cutting element comprises an element selected from the group consisting of needle, grasper, forceps, scalpel, scraper, scissors, brush, ablation tools, RF loops, heaters, laser ablation, probes, mechanical excision devices, x-ray, radiation, and cryosurgical probes.
Claim 37
Dependent Claim
21 words
35 . The lung device system of claim 24 , further comprising a sleeve in which the elongated body is disposed.
Claim 38
Dependent Claim
18 words
36 . The lung device system of claim 24 , wherein the hole closing element comprises a syringe.
Claim 39
Dependent Claim
18 words
37 . The lung device system of claim 24 , wherein the glutaraldehyde based sealant is tissue-bonding material.
Claim 40
Dependent Claim
22 words
38 . The lung device system of claim 24 wherein the glutaraldehyde based sealant has an adhesive force greater than 0.2 psi.
Claim 41
Dependent Claim
26 words
39 . The lung device system of claim 24 , wherein the glutaraldehyde based sealant has an adhesion force of from 0.2 psi to 0.6 psi.
Claim 42
Dependent Claim
25 words
40 . The lung device system of claim 24 wherein the glutaraldehyde based sealant has an adhesion force of from 0.6 psi to 3.0 psi.
Claim 43
Dependent Claim
20 words
41 . The lung device system of claim 24 , wherein the glutaraldehyde based sealant further comprises a detectable label.
Claim 44
Dependent Claim
24 words
42 . The lung device system of claim 41 , wherein the detectable label is an enzyme, a radioactive isotope, and a luminescent substance.
Claim 45
Dependent Claim
22 words
43 . The lung device system of claim 24 , wherein the glutaraldehyde based sealant has a viscosity greater than 1.1 centipoise.
Claim 46
Dependent Claim
27 words
44 . The lung device system of claim 24 , wherein the sealant comprises material selected from the group consisting of hydrogels, proteins, polymers and cross-linking agents.
Claim 47
Dependent Claim
31 words
45 . The lung device system of claim 44 , wherein the hydrogel material comprises material selected from the group consisting of hyalurons, hyalyronic acid, alginates, chitins, chitosans, and derivatives thereof.
Claim 48
Dependent Claim
28 words
46 . The lung device system of claim 44 , wherein the protein material comprises material selected from the group consisting of albumins, porcine albumins, collagens and gelatins.
Claim 49
Dependent Claim
26 words
47 . The lung device system of claim 44 , wherein the polymer material comprises material selected from the group consisting of poly(lactic acid) and poly(glycolide).
Claim 50
Dependent Claim
27 words
48 . The lung device system of claim 44 , wherein the cross-linking agent material comprises material selected from the group consisting of glutaraldehyde and stable polyaldehyde.
Claim 51
Dependent Claim
56 words
49 . A method of performing tissue treatment or diagnosis in a subject, comprising: delivering a device through an incision to a target site within the subject, the device comprising a sealant delivery element adapted to deliver a cross-linked sealant; performing treatment or diagnosis at the site; and delivering the cross-linked tissue sealant to the incision.
Claim 52
Dependent Claim
56 words
49 . A method of performing tissue treatment or diagnosis in a subject, comprising: delivering a device through an incision to a target site within the subject, the device comprising a sealant delivery element adapted to deliver a cross-linked sealant; performing treatment or diagnosis at the site; and delivering the cross-linked tissue sealant to the incision.
Claim 53
Dependent Claim
32 words
50 . The method of claim 49 further comprising the step of delivering a cross-linked tissue sealant through the incision prior to delivering the device through the incision to the target site.
Claim 54
Dependent Claim
15 words
51 . The method of claim 49 wherein the target site is a subject's lung.
Claim 55
Dependent Claim
25 words
52 . The method of claim 49 , further comprising removing the device while concurrently applying a biologically compatible cross-linked tissue sealant to the lung.
Claim 56
Dependent Claim
28 words
53 . The method of claim 49 , wherein the sealant delivery element is adapted to mitigate air leakage into a space between the lung and pleural membrane.
Claim 57
Dependent Claim
18 words
54 . The method of claim 49 , wherein the sealant delivery element is adapted to mitigate pneumothorax.
Claim 58
Dependent Claim
18 words
55 . The method of claim 49 , wherein the sealant delivery element is adapted to mitigate hemothorax.
Claim 59
Dependent Claim
16 words
56 . The method of claim 49 , wherein the device further comprises an imaging element.
Claim 60
Dependent Claim
25 words
57 . The method of claim 49 , wherein the device further comprises a delivery element adapted to deliver a pharmaceutical composition to the lung.
Claim 61
Dependent Claim
28 words
58 . The method of claim 49 , wherein the lung device comprises a distal end comprising a cutting element for excising tissue, the method comprising removing tissue.
Claim 62
Dependent Claim
21 words
59 . The method of performing a lung biopsy of claim 49 , wherein the sealant delivery element is a syringe.
Claim 63
Dependent Claim
21 words
60 . The method of performing a lung biopsy of claim 49 , wherein the sealant delivery element is a plunger.
Claim 64
Dependent Claim
23 words
61 . The method of performing a lung biopsy of claim 49 , wherein the biologically compatible cross-linked tissue sealant is tissue-bonding material.
Claim 65
Dependent Claim
25 words
62 . The method of claim 49 , wherein the sealant comprises material selected from the group consisting of hydrogels, proteins, polymers and cross-linking agents.
Claim 66
Dependent Claim
29 words
63 . The method of claim 62 , wherein the hydrogel material comprises material selected from the group consisting of hyalurons, hyalyronic acid, alginates, chitins, chitosans, and derivatives thereof.
Claim 67
Dependent Claim
26 words
64 . The method of claim 62 , wherein the protein material comprises material selected from the group consisting of albumins, porcine albumins, collagens and gelatins.
Claim 68
Dependent Claim
24 words
65 . The method of claim 62 , wherein the polymer material comprises material selected from the group consisting of poly(lactic acid) and poly(glycolide).
Claim 69
Dependent Claim
25 words
66 . The method of claim 62 , wherein the cross-linking agent material comprises material selected from the group consisting of glutaraldehyde and stable polyaldehyde.
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