US6685626B2
Expired / Lapsed
US
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Compositions, devices, methods, and kits for induction of adhesions
Assignee: RTI Surgical Inc
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Filing: 2001-02-02
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Granted: 2004-02-03
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Expires: 2021-02-02
Abstract
Abstract Disclosed and claimed are compositions, devices, methods and kits that are useful in surgical procedures, specifically to induce adhesions for the purposes of stabilizing implants, closing apertures, and otherwise promoting the adhesion of implants and anatomical structures to one another. The invention pertains to a composition containing specific particulate components, wherein the particulates promote an inflammatory reaction that results in the formation of an adhesion.
Inventors
- 👤 John F. Wironen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:11
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61L; A61L24/00; A61L24/0047; A61L24/0073; A61L24/0084; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/44; A61F2/442; A61F2002/4435; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
76 words
A surgical implant comprising: a. a generalized structure prepared from the group consisting of allograft, xenograft, autograft, processed or semi-processed products made from allograft, xenograft or autograft tissue, biomaterials, metals, synthetic polymers, and combinations thereof; and b. at least one sectioned adhesion-promoting area within said generalized structure comprising water-insoluble particles, wherein, at the site of implantation of said surgical implant, each sectioned adhesion-promoting area produces an adhesion to tissue in contact with said sectioned adhesion-promoting area.
Claim 2
Dependent Claim
76 words
A surgical implant comprising: a. a generalized structure prepared from the group consisting of allograft, xenograft, autograft, processed or semi-processed products made from allograft, xenograft or autograft tissue, biomaterials, metals, synthetic polymers, and combinations thereof; and b. at least one sectioned adhesion-promoting area within said generalized structure comprising water-insoluble particles, wherein, at the site of implantation of said surgical implant, each sectioned adhesion-promoting area produces an adhesion to tissue in contact with said sectioned adhesion-promoting area.
Claim 3
Dependent Claim
36 words
The implant according to claim 1 , wherein said water-insoluble particles are selected from the group consisting of fine particles of bone, fine particles of hydroxyapatite, non-osteoinductive demineralized bone matrix, collagen shards, insoluble salts, and talc.
Claim 4
Dependent Claim
14 words
The implant according to claim 1 , wherein said generalized structure is linearly shaped.
Claim 5
Dependent Claim
12 words
The implant according to claim 3 , which is a bladder sling.
Claim 6
Dependent Claim
23 words
The implant according to claim 4 , wherein said sectioned adhesion-promoting area is positioned at the middle top section of said bladder sling.
Claim 7
Dependent Claim
28 words
The implant according to claim 5 , wherein said sectioned adhesion-promoting area is adhered to the lower apical neck of the bladder upon implantation of said surgical implant.
Claim 8
Dependent Claim
23 words
The implant according to claim 2 , wherein said fine particles of hydroxyapatite range in particle size from 1 micrometer to 1,000 micrometers.
Claim 9
Dependent Claim
23 words
The implant according to claim 7 , wherein said fine particles of hydroxyapatite range in particle size from 1 micrometer to 70 micrometers.
Claim 10
Dependent Claim
21 words
The implant according to claim 2 , wherein said collagen shards range in particle size from 1 micrometer to 70 micrometers.
Claim 11
Independent Claim
79 words
A method of promoting the formation of an adhesion comprising: a. preparing a composition comprising water insoluble particles that promote formation of an adhesion, and b. injecting a quantity of said composition into a specified area of a living body, wherein said water-insoluble particles are selected from the group consisting of fine particles of bone, fine particles of hydroxyapatite, non-osteoinductive demineralized bone matrix, collagen shards, insoluble salts, and talc; and whereby an adhesion is formed at said specified area.
Claim 12
Independent Claim
79 words
A method of promoting the formation of an adhesion comprising: a. preparing a composition comprising water insoluble particles that promote formation of an adhesion, and b. injecting a quantity of said composition into a specified area of a living body, wherein said water-insoluble particles are selected from the group consisting of fine particles of bone, fine particles of hydroxyapatite, non-osteoinductive demineralized bone matrix, collagen shards, insoluble salts, and talc; and whereby an adhesion is formed at said specified area.
Claim 13
Dependent Claim
26 words
The method according to claim 10 , wherein the adhesion closes off an opening at or near the body area receiving the quantity of said composition.
Claim 14
Dependent Claim
31 words
The method according to claim 10 , wherein said composition comprises an aqueous gelatin solution suspended with ground bone fragments, wherein said bone fragments do not induce formation of new bone.
Claim 15
Dependent Claim
15 words
The method according to claim 10 , wherein the injecting is done with a syringe.
Claim 16
Dependent Claim
17 words
The method according to claim 11 , wherein said body area is the entrance of the uterus.
Claim 17
Dependent Claim
29 words
The method according to claim 14 , wherein injection of said composition at or near the entrance of the uterus produces a closure of said entrance of the uterus.
Claim 18
Independent Claim
95 words
A method of promoting formation of at least one adhesion comprising: a. preparing or obtaining an implant having at least one sectioned adhesion-promoting area, said area comprising a particulate material with adhesion-promoting properties affixed thereto, and b. surgically placing said implant in a living body wherein each said sectioned adhesion-promoting area is positioned adjacent to a specified tissue or organ area of said living body on which adhesion formation is desired, whereby formation of an adhesion is promoted between each said sectioned adhesion-promoting area and said specified tissue or organ area in said living body.
Claim 19
Independent Claim
95 words
A method of promoting formation of at least one adhesion comprising: a. preparing or obtaining an implant having at least one sectioned adhesion-promoting area, said area comprising a particulate material with adhesion-promoting properties affixed thereto, and b. surgically placing said implant in a living body wherein each said sectioned adhesion-promoting area is positioned adjacent to a specified tissue or organ area of said living body on which adhesion formation is desired, whereby formation of an adhesion is promoted between each said sectioned adhesion-promoting area and said specified tissue or organ area in said living body.
Claim 20
Dependent Claim
38 words
The method according to claim 16 , additionally comprising: c. affixing each sectioned adhesion-promoting area to each adjacent specified tissue or organ area, thereby stably positioning said specified tissue or organ area during the formation of an adhesion.
Claim 21
Dependent Claim
24 words
The method according to claim 17 , wherein step (c) comprises suturing each sectioned adhesion-promoting area to each adjacent specified tissue or organ area.
Claim 22
Dependent Claim
23 words
The method according to claim 17 , wherein step (c) further comprises inducing at least one enzyme that promotes adhesion through enzymatic catalysis.
Claim 23
Dependent Claim
12 words
The method according to claim 19 , wherein said enzyme is transglutaminase.
Claim 24
Dependent Claim
17 words
The method according to claim 17 , wherein step (c) is performed by using a polymerizable collagen.
Claim 25
Dependent Claim
92 words
A kit for implanting an implant that will form an adhesion with a tissue or organ in a living body, comprising: a. an implant comprising an implant structure having at least one sectioned adhesion-promoting area that is a means for formation of an adhesion to a tissue or organ of the living body; and b. instructions for placement of said implant, wherein upon proper surgical implantation, said at least one sectioned adhesion-promoting area forms at least one adhesion with at least one portion of a tissue or organ of the living body.
Claim 26
Dependent Claim
92 words
A kit for implanting an implant that will form an adhesion with a tissue or organ in a living body, comprising: a. an implant comprising an implant structure having at least one sectioned adhesion-promoting area that is a means for formation of an adhesion to a tissue or organ of the living body; and b. instructions for placement of said implant, wherein upon proper surgical implantation, said at least one sectioned adhesion-promoting area forms at least one adhesion with at least one portion of a tissue or organ of the living body.
Claim 27
Dependent Claim
100 words
An implant for treating incontinence in a patient having a bladder and a urethra comprising an elongated structure having two opposing ends for attachment in proximity to said bladder in said patient, said elongated structure having a first portion which contacts the urethra at the neck of said bladder in said patient, said first portion having thereon at least one sectioned adhesion-promoting area comprising adhesion forming particulates in a carrier for forming an adhesion between said first portion of said implant and said urethra at the neck of said bladder, whereby said implant applies pressure to said urethra without slippage.
Claim 28
Dependent Claim
100 words
An implant for treating incontinence in a patient having a bladder and a urethra comprising an elongated structure having two opposing ends for attachment in proximity to said bladder in said patient, said elongated structure having a first portion which contacts the urethra at the neck of said bladder in said patient, said first portion having thereon at least one sectioned adhesion-promoting area comprising adhesion forming particulates in a carrier for forming an adhesion between said first portion of said implant and said urethra at the neck of said bladder, whereby said implant applies pressure to said urethra without slippage.
Claim 29
Dependent Claim
12 words
The implant of claim 23 , wherein said particulates have sharp points.
Claim 30
Dependent Claim
20 words
The implant of claim 24 , wherein said particulates have a particle size from 1 micrometer to 1,000 micrometers (microns).
Claim 31
Dependent Claim
11 words
The implant of claim 25 , wherein said particulates are hydroxyapatite.
Claim 32
Dependent Claim
11 words
The implant of claim 24 , wherein said carrier is gelatin.
Claim 33
Dependent Claim
16 words
The implant of claim 23 , wherein said elongated material is an allograft, xenograft, or autograft.
Claim 34
Dependent Claim
12 words
The implant of claim 24 , wherein the particulate is collagen shards.
Claim 35
Dependent Claim
13 words
The implant of claim 24 , wherein the particulate is particles of bone.
Claim 36
Dependent Claim
20 words
The implant of claim 29 , wherein the collagen shards have a size range of 1 micrometer to 70 micrometers.
Claim 37
Dependent Claim
21 words
The implant of claim 30 , wherein the particles of bone have a size range of 1 micrometer to 70 micrometers.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2007-02-02 | 2007-08-04 | 2008-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2011-02-02 | 2011-08-04 | 2012-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2015-02-02 | 2015-08-04 | 2016-02-03 | $7700.00 | Window Closed / Lapsed |