US5752974A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
Assignee: Angiotech Pharmaceuticals Inc
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Filing: 1995-12-18
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Granted: 1998-05-19
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Expires: 2015-12-18
Abstract
Abstract Methods for completely or partially blocking, augmenting, sealing, or filling various biological lumens and voids within the body of a patient are disclosed. Lumens include arteries, veins, intestines, Fallopian tubes, and trachea. Voids include various lesions, fissures, diverticulae, cysts, fistulae, aneurysms, or other undesirable voids that may exist within a patient's body. In the most general method of the invention, an effective amount of a biomaterial is administered (e.g., via injection, catheter, or surgical implantation) into the lumen or void. Preferred biomaterial compositions for use in the present invention are disclosed.
Inventors
- 👤 Woonza M. Rhee
- 👤 Richard A. Berg
- 👤 George H. Chu
- 👤 Frank A. Delustro
- 👤 Dan M. Jolivette
- 👤 Kimberly A. McCullough
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:04
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/04; A61L31/043; A61L31/044; A61L24/00; A61L24/04; A61L24/043; A61L24/10; A61L24/102; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; A61L27/00; A61L27/14; A61L27/18; A61L27/20; A61L27/22; A61L27/24; A61L27/26; A61L31/041; A61P; A61P15/00; A61P15/18; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2400/00; A61L2400/06; A61L2430/00; A61L2430/36
Claims Analysis
Total Claims: 51
Claim 1
Independent Claim
82 words
A method for completely or partially blocking, augmenting, sealing, or filling a lumen or void within the body comprising the steps of: a) providing a polymer and a hydrophilic crosslinking agent in suspension or solution to form an injectable or implantable biomaterial; b) injecting or implanting the biomaterial into a lumen or void within the body; and c) allowing the biomaterial to anchor to body tissue surrounding the lumen or void to totally or partially block or fill the lumen or void.
Claim 2
Independent Claim
82 words
A method for completely or partially blocking, augmenting, sealing, or filling a lumen or void within the body comprising the steps of: a) providing a polymer and a hydrophilic crosslinking agent in suspension or solution to form an injectable or implantable biomaterial; b) injecting or implanting the biomaterial into a lumen or void within the body; and c) allowing the biomaterial to anchor to body tissue surrounding the lumen or void to totally or partially block or fill the lumen or void.
Claim 3
Dependent Claim
30 words
The method of claim 1 wherein the polymer is selected from the group consisting of a protein, a synthetic polypeptide, a glycosaminoglycan, a proteoglycan, a polymeric hydrogel, and mixtures thereof.
Claim 4
Dependent Claim
26 words
The method of claim 2, wherein the polymer is crosslinked with the crosslinking agent prior to step b), thereby to form a biomaterial which is crosslinked.
Claim 5
Dependent Claim
50 words
The method of claim 3, wherein the crosslinked biomaterial is dehydrated prior to step b), and wherein, in step c), the biomaterial rehydrates and swells, thereby allowing the biomaterial to anchor to body tissue surrounding the lumen or void to totally or partially block or fill the lumen or void.
Claim 6
Dependent Claim
31 words
The method of claim 4, wherein the dehydrated crosslinked biomaterial is present in particulate form, suspended in a pharmaceutically acceptable nonaqueous carrier, and administered by injection into the lumen or void.
Claim 7
Dependent Claim
28 words
The method of claim 4, wherein the dehydrated crosslinked biomaterial is present in rod form and administered into the lumen or void via a catheter or an endoscope.
Claim 8
Dependent Claim
21 words
The method of claim 3, wherein the crosslinking agent is selected from the group consisting of aldehydes, carbodiimides, epoxides, and imidazoles.
Claim 9
Dependent Claim
14 words
The method of claim 3, wherein the crosslinking agent is a synthetic hydrophilic polymer.
Claim 10
Dependent Claim
16 words
The method of claim 8, wherein the synthetic hydrophilic polymer is a functionally activated polyethylene glycol.
Claim 11
Dependent Claim
16 words
The method of claim 9, wherein the synthetic hydrophilic polymer is a difunctionally activated polyethylene glycol.
Claim 12
Dependent Claim
11 words
The method of claim 2, wherein the polymer is a protein.
Claim 13
Dependent Claim
10 words
The method of claim 11, wherein the protein is collagen.
Claim 14
Dependent Claim
11 words
The method of claim 12, wherein the collagen is fibrillar collagen.
Claim 15
Dependent Claim
20 words
The method of claim 13, wherein the collagen comprises a mixture of particulate crosslinked fibrillar collagen and noncrosslinked fibrillar collagen.
Claim 16
Dependent Claim
35 words
The method of claim 14, wherein the particulate crosslinked fibrillar collagen comprises between about 25% to about 95% and the noncrosslinked fibrillar collagen comprises between about 5% to about 75% by weight of the composition.
Claim 17
Dependent Claim
11 words
The method of claim 12, wherein the collagen is nonfibrillar collagen.
Claim 18
Dependent Claim
12 words
The method of claim 16, wherein the nonfibrillar collagen is methylated collagen.
Claim 19
Dependent Claim
11 words
The method of claim 12, wherein the collagen is denatured collagen.
Claim 20
Dependent Claim
36 words
The method of claim 2, wherein the polymer is a glycosaminoglycan selected from the group consisting of hyaluronic acid, chondroitin sulfate A, chondroitin sulfate C, dermatan sulfate, keratan sulfate, keratosulfate, chitin, chitosan, heparin, and derivatives thereof.
Claim 21
Dependent Claim
11 words
The method of claim 19, wherein the glycosaminoglycan is hyaluronic acid.
Claim 22
Dependent Claim
21 words
The method of claim 1, wherein the polymer comprises a crosslinked mixture of collagen and one or more species of glycosaminoglycan.
Claim 23
Dependent Claim
45 words
The method of claim 1, wherein the biomaterial further comprises one or more biocompatible fluid lubricant selected from the group consisting of hyaluronic acid, dextran sulfate, dextran, succinylated noncrosslinked collagen, methylated noncrosslinked collagen, glycogen, glycerol, dextrose, maltose, triglycerides of fatty acids, and egg yolk phospholipid.
Claim 24
Dependent Claim
47 words
The method of claim 1, wherein the biomaterial further comprises a particulate material selected from the group consisting of ceramic particles, crosslinked or noncrosslinked particulate fibrillar collagen, gelatin beads, polytetrafluoroethylene beads, silicone rubber beads, beads of various hydrogel polymers, silicon carbide beads, glass beads, and mixtures thereof.
Claim 25
Dependent Claim
36 words
The method of claim 1, wherein the biomaterial further comprises an effective amount of one or more biologically active agent selected from the group consisting of a wound healing agent, an antibiotic, and an antimicrobial agent.
Claim 26
Dependent Claim
53 words
The method of claim 24, wherein the biologically active agent is a wound healing agent selected from the group consisting of: transforming growth factors (TGFs), fibroblast growth factors (FGFs), platelet derived growth factors (PDGFs), epidermal growth factors (EGFs), connective tissue activated peptides (CTAPs), osteogenic factors, and biologically active analogs, fragments, and derivatives thereof.
Claim 27
Dependent Claim
37 words
The method of claim 1, wherein the method further comprises the step of selecting a lumen from the group consisting of a Fallopian tube, a trachea, an artery, a vein, and an intestine prior to step b).
Claim 28
Dependent Claim
35 words
The method of claim 1, wherein the method further comprises the step of selecting a void from the group consisting of aneurysms, lesions, fissures, fistulae, cysts, and diverticulae of any organ prior to step b).
Claim 29
Dependent Claim
31 words
The method of claim 1, wherein the method further comprises selecting a void caused by a surgical, chemical, or biological removal of growths, fluids, cells, or tissues prior to step b).
Claim 30
Dependent Claim
65 words
The method of claim 1, wherein the polymer and the crosslinking agent are administered by injection into the lumen or void before substantial crosslinking has occurred between the polymer and the crosslinking agent, and wherein crosslinking of the polymer and crosslinking agent is completed after administration to the lumen or void, thereby permitting the biomaterial to anchor to body tissue surrounding the lumen or void.
Claim 31
Dependent Claim
41 words
The method of claim 1 wherein the polymer and the hydrophilic crosslinking agent are crosslinked after injection or implantation of the biomaterial into the lumen or void, thereby permitting the biomaterial to anchor to body tissue surrounding the lumen or void.
Claim 32
Dependent Claim
12 words
The method of claim 1 wherein the polymer is a synthetic polymer.
Claim 33
Dependent Claim
11 words
The method of claim 1 wherein the polymer comprises polyethylene glycol.
Claim 34
Dependent Claim
16 words
The method of claim 32 wherein the hydrophilic crosslinking agent comprises a functionally activated polyethylene glycol.
Claim 35
Dependent Claim
18 words
The method of claim 1 wherein the biomaterial is injected or implanted within a lumen in the body.
Claim 36
Independent Claim
49 words
A method for completely or partially blocking, augmenting, sealing, or filling a biological lumen or void within the body of a patient comprising administering an effective amount of a biomaterial into the lumen or void; wherein the biomaterial is crosslinked using a mixture of hydrophilic and hydrophobic crosslinking agents.
Claim 37
Independent Claim
49 words
A method for completely or partially blocking, augmenting, sealing, or filling a biological lumen or void within the body of a patient comprising administering an effective amount of a biomaterial into the lumen or void; wherein the biomaterial is crosslinked using a mixture of hydrophilic and hydrophobic crosslinking agents.
Claim 38
Dependent Claim
16 words
The method of claim 35, wherein the hydrophilic crosslinking agent is a functionally activated polyethylene glycol.
Claim 39
Dependent Claim
27 words
The method of claim 35, wherein the hydrophobic crosslinking agent is a hydrophobic polymer which contains two or more succinimidyl groups prior to bonding with the biomaterial.
Claim 40
Dependent Claim
29 words
The method of claim 37, wherein the hydrophobic polymer is selected from the group consisting of: disuccinimidyl suberate, bis(sulfosuccinimidyl) suberate, dithiobis(succinimidylpropionate), bis(2-succinimidooxycarbonyloxy)ethyl sulfone, 3,3'-dithiobis(sulfosuccinimidyl)propionate, and analogs and derivatives thereof.
Claim 41
Dependent Claim
11 words
The method of claim 35, wherein the biomaterial is a protein.
Claim 42
Dependent Claim
10 words
The method of claim 39, wherein the protein is collagen.
Claim 43
Dependent Claim
11 words
The method of claim 40, wherein the collagen is fibrillar collagen.
Claim 44
Dependent Claim
11 words
The method of claim 35, wherein the biomaterial comprises a glycosaminoglycan.
Claim 45
Dependent Claim
20 words
The method of claim 35, wherein the biomaterial further comprises an effective amount of one or more biologically active agent.
Claim 46
Dependent Claim
37 words
The method of claim 35, wherein the method further comprises the step of selecting a lumen from the group consisting of a Fallopian tube, a trachea, an artery, a vein, and an intestine prior to step b).
Claim 47
Dependent Claim
33 words
The method of claim 35, wherein the biomaterial and the crosslinking agent are administered by injection into the lumen or void before substantial crosslinking has occurred between the biomaterial and the crosslinking agent.
Claim 48
Independent Claim
90 words
A method for completely or partially blocking, augmenting, sealing, or filling a biological lumen or void within the body of a patient comprising administering an effective amount of a biomaterial into the lumen or void; wherein the biomaterial is a polymeric hydrogel which comprises a first synthetic polymer crosslinked using a second synthetic polymer, wherein the first synthetic polymer contains two or more nucleophilic groups, and the second synthetic polymer contains two or more electrophilic groups capable of forming covalent bonds with the nucleophilic groups on the first synthetic polymer.
Claim 49
Independent Claim
90 words
A method for completely or partially blocking, augmenting, sealing, or filling a biological lumen or void within the body of a patient comprising administering an effective amount of a biomaterial into the lumen or void; wherein the biomaterial is a polymeric hydrogel which comprises a first synthetic polymer crosslinked using a second synthetic polymer, wherein the first synthetic polymer contains two or more nucleophilic groups, and the second synthetic polymer contains two or more electrophilic groups capable of forming covalent bonds with the nucleophilic groups on the first synthetic polymer.
Claim 50
Dependent Claim
10 words
The method of claim 46, wherein the biomaterial comprises collagen.
Claim 51
Dependent Claim
14 words
The method of claim 46, wherein the biomaterial further comprises a biologically active agent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-05-18 | 2001-11-17 | 2002-05-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-05-18 | 2005-11-17 | 2006-05-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-05-18 | 2009-11-17 | 2010-05-19 | $7700.00 | Window Closed / Lapsed |