Patent EP0708102A1 successfully refreshed from Google Patents.
EP0708102A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
5-HT1F agonists for the treatment of migraine
Assignee: Eli Lilly and Co
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Filing: 1995-10-03
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Granted: —
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Expires: 2015-10-03
Abstract
Abstract This invention provides novel 5-HT 1F agonists which are useful for the treatment of migraine and associated disorders, of the following formula in which A-B is -CH-CH₂- or -C=CH-; X is H, halo, C₁-C₄ alkyl, C₁-C₄ alkoxy, C₁-C₄ alkylthio, benzyloxy, hydroxy or carboxamido; n is 1-4; Ar is pyrrolyl or a structure of Formula II: where R¹ is H, C₁-C₆ alkyl, C₃-C₇ cycloalkyl, C₃-C₇ cycloalkylmethyl, benzyl, phenyl or substituted phenyl or a pharmaceutically acceptable acid addition salt or hydrate thereof.
Inventors
- 👤 James Edmund Audia
- 👤 Jeffrey Scott Nissen
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 22:28
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/14; A; A61; A61P; A61P25/00; A61P25/04; A61P25/06
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
63 words
A compound of Formula I: in which A-B is -CH-CH₂- or -C=CH-; X is H, halo, C₁-C₄ alkyl, C₁-C₄ alkoxy, C₁-C₄ alkylthio, benzyloxy, hydroxy or carboxamido; n is 1-4; Ar is pyrrolyl or a structure of Formula II: where R¹ is H, C₁-C₆ alkyl, C₃-C₇ cycloalkyl, C₃-C₇ cycloalkylmethyl, benzyl, phenyl or substituted phenyl or a pharmaceutically acceptable acid addition salt or hydrate thereof.
Claim 2
Dependent Claim
10 words
A compound of Claim 1, in which A-B is -C=CH-.
Claim 3
Dependent Claim
10 words
A compound of Claim 1, in which A-B is -CH-CH₂-.
Claim 4
Dependent Claim
16 words
A compound of any of Claims 1-3, in which Ar is a structure of Formula II.
Claim 5
Dependent Claim
14 words
A compound of any of Claims 1-4, in which n is 2 or 3.
Claim 6
Dependent Claim
27 words
A pharmaceutical formulation comprising as an active ingredient, a compound as claimed in any one of claims 1-5, associated with one or more pharmaceutically acceptable carriers therefor.
Claim 7
Dependent Claim
71 words
A compound of Formula III: in which A-B is -CH-CH₂- or -C=CH-; X is H, halo, C₁-C₄ alkyl, C₁-C₄ alkoxy, C₁-C₄ alkylthio, benzyloxy, hydroxy or carboxamido; n is 1-4; Ar is pyridinyl, pyrrolyl or a structure of Formula II: where R¹ is H, C₁-C₆ alkyl, C₃-C₇ cycloalkyl, C₃-C₇ cycloalkylmethyl, benzyl, phenyl or substituted phenyl and pharmaceutically acceptable acid addition salts thereof, for use in the treatment of migraine and associated disorders.
Claim 8
Dependent Claim
18 words
A compound as claimed in Claim 7, for use in the inhibition of neuronal protein extravasation in mammals.
Claim 9
Dependent Claim
18 words
A compound as claimed in Claim 7, for use in the activation of 5-HT 1F receptors in mammals.
References Cited (Backward Citations)
EP0303506A2
Cited
US5045550A
Cited
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