Indole derivatives

Abstract

Abstract Compounds are disclosed of formula (I) wherein R₁ represents H or C₁₋₆ alkyl; R₂ represents H, C₁₋6 alkyl, C₃₋₇ cycloalkyl, C₃₋₆ alkenyl, phenyl or phen(C₁₋₃)alkyl in which the phenyl ring is optionally substituted by halogen, C₁₋₄ alkoxy, hydroxy or C₁₋₃ alkyl; R₃ represents H, C₁₋₃ alkyl, -CO₂R₅, -COR₅, -COCO₂R₅ or -CONHR₅ where R₅ represents H, C₁₋₄ alkyl, C₃₋₇ cycloalkyl, C₂₋₄ alkenyl, aryl or ar(C₁₋₄)alkyl in which the aryl group is optionally substituted by halogen, C₁₋₄ alkoxy, C₁₋₄ alkyl or hydroxy) (provided that where R₃ represents -CO₂R₅, R₅ is other than H); R₄ represents H, C₁₋₃ alkyl, C₃₋₆ alkenyl, phenyl or phen(C₁₋₃)alkyl; A-B represents CH-CH₂- or C=CH- D represents -CO- or -SO₂- n represents 0, 1-5; provided that when D represents -SO₂, n is 2, R₃ represents H and R₄ represents H or C₁₋₃ alkyl, R₂ is other than H or C₁₋₆ alkyl; and pharmaceutically acceptable salts and solvates (for example hydrates) thereof. The compounds are indicated as useful for the treatment of migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders. Processes and intermediates for their preparation and pharmaceutical compositions containing them are also disclosed.

Inventors

• 👤 Alexander William Oxford
• 👤 Ian Harold Coates
• 👤 Darko Butina

Bibliographic Details