US5045550A
Expired / Lapsed
US
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Substituted tetrahydropyridines as central nervous system agents
Assignee: Warner Lambert Co LLC
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Filing: 1990-09-20
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Granted: 1991-09-03
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Expires: 2010-09-20
Abstract
Abstract Substituted tetrahydropyridines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
Inventors
- 👤 Juan C. Jaen
- 👤 David G. Nickell
- 👤 Donna M. Reynolds
- 👤 Sarah J. Smith
- 👤 Lawrence D. Wise
- 👤 David J. Wustrow
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 22:04
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06; C07D401/14; C07D409/00; C07D409/14
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
37 words
A compound of Formula I ##STR11## wherein R is ##STR12## X is ##STR13## or --CH 2 --; n is an integer of 2 to 4; R 1 is aryl; or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
37 words
A compound of Formula I ##STR11## wherein R is ##STR12## X is ##STR13## or --CH 2 --; n is an integer of 2 to 4; R 1 is aryl; or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
19 words
A compound according to claim 3 selected from the group consisting of: 4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-1-(3-pyridinyl)-1-butanone; 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]pyridine; 4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)-1-(4-pyridinyl)-1-butanone; 4-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]pyridine; 4-[3-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)propyl]pyridine; and 4-[5-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)pentyl]pyridine.
Claim 4
Dependent Claim
40 words
A method of treating psychoses, depression, hypertension, galactorrhead, amenorrhead, menstrual disorders, sexual dysfunction, Parkinson's disease, or Huntington's chorea comprising administering to a host suffering therefrom a therapeutic effective amount of a compound according to claim 1 in unit dosage form.
Claim 5
Dependent Claim
27 words
A method of treating schizophrenia comprising administering to a host suffering therefrom a therapeutic effective amount of a compound according to claim 1 in unit dosage form.
Claim 6
Dependent Claim
27 words
A method of treating depression comprising administering to a host suffering therefrom a therapeutic effective amount of a compound according to claim 1 in unit dosage form.
Claim 7
Dependent Claim
36 words
A pharmaceutical composition adapted for administration as a dopaminergic, antipsychotic, antihypertensive or antidepressant agent comprising a therapeutic effective amount of a compound according to claim 1 in admixture with a pharmaceutically acceptable excipient, diluent or carrier.
References Cited (Backward Citations)
US4665187A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-09-02 | 1995-03-04 | 1995-09-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-02 | 1999-03-04 | 1999-09-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-02 | 2003-03-04 | 2003-09-03 | $7700.00 | Window Closed / Lapsed |