EP0338418A1 — A blood compatible, lubricious article and compos…

Claim 1

Independent Claim 87 words

A composition for coating a polymeric surface comprising a mixture of a quanternary ammonium complex of heparin and about 2 to 75% by weight of a lubricating silicone, said complex having the formula wherein R₁, R₂, R₃ and R₄ are independently selected from the group consisting of an alkyl group of 1 to about 18 carbon atoms and an aralkyl group of about 7 to 18 carbon atoms and H⁻ is a negative ion of heparin, said silicone having a viscosity of about 20 to 1,000,000 centistokes.

Claim 2

Dependent Claim 87 words

A composition for coating a polymeric surface comprising a mixture of a quanternary ammonium complex of heparin and about 2 to 75% by weight of a lubricating silicone, said complex having the formula wherein R₁, R₂, R₃ and R₄ are independently selected from the group consisting of an alkyl group of 1 to about 18 carbon atoms and an aralkyl group of about 7 to 18 carbon atoms and H⁻ is a negative ion of heparin, said silicone having a viscosity of about 20 to 1,000,000 centistokes.

Claim 3

Dependent Claim 12 words

The composition of Claim 1 wherein said silicone is a polydialkyl siloxane.

Claim 4

Dependent Claim 25 words

The composition of Claim 1 wherein R₁, R₂ and R₃ are independently alkyl groups selected from the group having from 8 to 18 carbon atoms.

Claim 5

Dependent Claim 37 words

A composition for coating a surface comprising a mixture of an anticoagulant and about 2 to 75% by weight of a water insoluble lubricating silicone, said silicone having a viscosity of from about 20 to 1,000,000 centistokes.

Claim 6

Dependent Claim 37 words

A composition for coating a surface comprising a mixture of an anticoagulant and about 2 to 75% by weight of a water insoluble lubricating silicone, said silicone having a viscosity of from about 20 to 1,000,000 centistokes.

Claim 7

Dependent Claim 25 words

The composition of Claim 4 wherein said anticoagulant is selected from the group consisting of heparin, prostaglandins, urokinase, streptokinase, tissue plasminogen activator and a heparinoid.

Claim 8

Dependent Claim 85 words

A composition for coating a polymeric surface comprising a mixture of a lubricating oil and an ammonium complex of heparin, said complex having the formula wherein R₁ is selected from the group consisting of an alkyl group of about 7 to 18 carbon atoms and R₂, R₃ and R₄ are independently selected from the group consisting of hydrogen, an alkyl group of 1 to 18 carbon atoms and an aralkyl group of 7 to 18 carbon atoms, and H⁻ is a negative ion of heparin.

Claim 9

Dependent Claim 85 words

A composition for coating a polymeric surface comprising a mixture of a lubricating oil and an ammonium complex of heparin, said complex having the formula wherein R₁ is selected from the group consisting of an alkyl group of about 7 to 18 carbon atoms and R₂, R₃ and R₄ are independently selected from the group consisting of hydrogen, an alkyl group of 1 to 18 carbon atoms and an aralkyl group of 7 to 18 carbon atoms, and H⁻ is a negative ion of heparin.

Claim 10

Dependent Claim 97 words

A medical device for contact with a blood stream comprising an article having coated thereon a composition comprising a mixture of a quaternary ammonium complex of heparin and about 2 to 75% by weight of a lubricating silicone, said complex having the formula wherein R₁, R₂, R₃ and R₄ are independently selected from the group consisting of an alkyl group of 1 to about 18 carbon atoms and an aralkyl group of about 7 to 18 carbon atoms and H⁻ is a negative ion of heparin, said silicone having a viscosity of about 20 to 1,000,000 centistokes.

Claim 11

Dependent Claim 97 words

A medical device for contact with a blood stream comprising an article having coated thereon a composition comprising a mixture of a quaternary ammonium complex of heparin and about 2 to 75% by weight of a lubricating silicone, said complex having the formula wherein R₁, R₂, R₃ and R₄ are independently selected from the group consisting of an alkyl group of 1 to about 18 carbon atoms and an aralkyl group of about 7 to 18 carbon atoms and H⁻ is a negative ion of heparin, said silicone having a viscosity of about 20 to 1,000,000 centistokes.

Claim 12

Dependent Claim 105 words

A medical device for contact with a blood stream comprising a shaped article having coated thereon a composition comprising a mixture of a quanternary ammonium complex of heparin and about 20 to 50% by weight of a lubricating polydimethylsiloxane, said complex having the formula wherein R₁, R₂ and R₃ are independently selected from the group consisting of a straight chain alkyl group of 8 to 18 carbon atoms, R₄ is selected from the group consisting of a lower alkyl group of 1 to 4 carbon atoms and H⁻ is a negative ion of heparin, said polydimethylsiloxane having a viscosity of about 1,000 to 60,000 centistokes.

Claim 13

Dependent Claim 105 words

A medical device for contact with a blood stream comprising a shaped article having coated thereon a composition comprising a mixture of a quanternary ammonium complex of heparin and about 20 to 50% by weight of a lubricating polydimethylsiloxane, said complex having the formula wherein R₁, R₂ and R₃ are independently selected from the group consisting of a straight chain alkyl group of 8 to 18 carbon atoms, R₄ is selected from the group consisting of a lower alkyl group of 1 to 4 carbon atoms and H⁻ is a negative ion of heparin, said polydimethylsiloxane having a viscosity of about 1,000 to 60,000 centistokes.

Claim 14

Independent Claim 101 words

A method for rendering a surface of a medical article both antithrombogenic and lubricious comprising preparing a composition by mixing a quanternary ammonium complex of heparin and a lubricating silicone, said complex having the formula wherein R₁, R₂ and R₃ and R₄ are independently selected from the group consisting of an alkyl group of 1 to about 18 carbon atoms and an aralkyl group of about 7 to 18 carbon atoms and H⁻ is a negative ion of heparin, said silicone having a viscosity of about 20 to 1,000,000 centistokes, and applying said composition to said surface of said medical article.

Claim 15

Independent Claim 101 words

A method for rendering a surface of a medical article both antithrombogenic and lubricious comprising preparing a composition by mixing a quanternary ammonium complex of heparin and a lubricating silicone, said complex having the formula wherein R₁, R₂ and R₃ and R₄ are independently selected from the group consisting of an alkyl group of 1 to about 18 carbon atoms and an aralkyl group of about 7 to 18 carbon atoms and H⁻ is a negative ion of heparin, said silicone having a viscosity of about 20 to 1,000,000 centistokes, and applying said composition to said surface of said medical article.

Claim 16

Dependent Claim 25 words

The method in accordance with Claim 9 wherein said mixing is performed by dissolving said complex and silicone in a solvent to provide a solution.

Claim 17

Dependent Claim 35 words

The method in accordance with Claim 10 wherein said applying is performed by immersing said article in said solution, withdrawing said article from said solution and evaporating said solvent from the surface of said article.

A blood compatible, lubricious article and composition and method therefor

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