EP0184465A2
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EP
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A thermoplastic polyurethane product
Assignee: Deseret Medical Inc
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Filing: 1985-12-06
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Granted: —
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Expires: 2005-12-06
Abstract
Abstract An antithrombogenic thermoplastic polyurethane product, and process for preparing the same, the product comprising a substrate and at least one layer of a polyurethane alloy complex comprising a thermoplastic polyurethane and completely dispersed therein a preformed complex of an antithrombogenic material and/or an antibiotic agent ionically bonded with a quaternary ammonium compound.
Inventors
- 👤 Charles W. Mcgary
- 👤 Donald D. Solomon
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 22:35
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L27/00; A61L27/50; A61L27/54; A61L29/00; A61L29/14; A61L29/16; C; C08; C08K; C08K5/00; C08K5/0008; C08K5/16; C08K5/17; C08K5/19; C09; C09D; C09D175/00; C09D175/04; A61L2300/00; A61L2300/20; A61L2300/204; A61L2300/208; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/42; A61L2300/45; Y; Y10; Y10S; Y10S128/00; Y10S128/22
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
53 words
A thermoplastic polyurethane product which comprises a substrate and at least one layer of a polyurethane alloy complex comprising a thermoplastic polyurethane and, completely dispersed therein, a preformed complex of a material chosen from an antithrombogenic material, an antibiotic agent and mixtures thereof, said material being ionically bonded with a quaternary ammonium compound,
Claim 2
Dependent Claim
53 words
A thermoplastic polyurethane product which comprises a substrate and at least one layer of a polyurethane alloy complex comprising a thermoplastic polyurethane and, completely dispersed therein, a preformed complex of a material chosen from an antithrombogenic material, an antibiotic agent and mixtures thereof, said material being ionically bonded with a quaternary ammonium compound,
Claim 3
Dependent Claim
22 words
A thermoplastic polyurethane product according to Claim 1, wherein the antithrombogenic material is chosen from heparin, prostaglandins, sulphated polysaccharide, and mixtures thereof.
Claim 4
Dependent Claim
31 words
A thermoplastic polyurethane product according to Claim 1, wherein the antibiotic material is chosen from: penicillin, oxacillin, ticarcillin, carbenicillin, cephalosporins, cefoxitin, cefazolin, dicloxacall- in, cloxacillin, and clavulanic acid and mixtures thereof.
Claim 5
Dependent Claim
33 words
A thermoplastic polyurethane product according to Claim 1, 2 or 3, wherein an organic solvent is employed in the formation of the polyurethane complex, the substrate being substantially insoluble in the organic solvent.
Claim 6
Dependent Claim
38 words
A thermoplastic polyurethane product according to any preceding claim, wherein the quaternary ammonium compound is a long-chain alkyl quaternary ammonium salt having from 2 to 4 alkyl groups each alkyl group having from 10 to 30 carbon atoms.
Claim 7
Dependent Claim
27 words
A thermoplastic polyurethane product according to any preceding claim, wherein the quaternary ammonium compound is chosen from tridodecylmethyl ammonium salts, tetradodecyl ammonium salts and tridodecylbenzyl ammonium salts.
Claim 8
Dependent Claim
23 words
A thermoplastic polyurethane product according to any preceding claim, wherein a crosslinking agent is employed to render the polyurethane product thermosetting in nature.
Claim 9
Independent Claim
90 words
A method for preparing a slow release antithrombogenic/antibiotic thermoplastic polyurethane product, which comprises: contacting a preformed substrate with an organic solvent having dissolved therein (a) a thermoplastic polyurethane and (b) a preformed complex of (i) a material chosen from an antithrombogenic material, an antibiotic material and mixtures thereof and (ii) a quaternary ammonium compound, wherein contacting is performed for a time sufficient to form a thin film of the complex upon the substrate; and removing the solvent from the thermoplastic polyurethane layer to form the slow release thermoplastic polyurethane product.
Claim 10
Independent Claim
90 words
A method for preparing a slow release antithrombogenic/antibiotic thermoplastic polyurethane product, which comprises: contacting a preformed substrate with an organic solvent having dissolved therein (a) a thermoplastic polyurethane and (b) a preformed complex of (i) a material chosen from an antithrombogenic material, an antibiotic material and mixtures thereof and (ii) a quaternary ammonium compound, wherein contacting is performed for a time sufficient to form a thin film of the complex upon the substrate; and removing the solvent from the thermoplastic polyurethane layer to form the slow release thermoplastic polyurethane product.
Claim 11
Dependent Claim
21 words
A method according to Claim 8, wherein the antithrombogenic material is chosen from heparin , prostaglandins, sulphated polysaccharide, and mixtures thereof.
Claim 12
Dependent Claim
28 words
A method according to Claim 8, wherein the antibiotic material is chosen from penicillin, oxacillin, ticarcillin, carbenicillin, cephalosporins, cefoxitin, cefazolin, dicloxacillin, cloxacillin, and clavulanic acid, and mixtures thereof.
Claim 13
Dependent Claim
30 words
A method according to Claim 8, 9 or 10, wherein the substrate is substantially insoluble in the organic solvent used to dissolve the thermoplastic polyurethane and the antithrombogenic antibiotic material.
Claim 14
Dependent Claim
40 words
A method according to Claim 8, 9, 10 or 11, wherein the quaternary ammonium compound is a long chain alkyl quaternary ammonium salt having from 2 to 4 alkyl groups each alkyl group having from 10 to 30 carbon atoms.
Claim 15
Independent Claim
29 words
A method according to any one of Claims 8 to 12, wherein the quaternary ammonium compound is chosen from tridodecylmethyl ammonium salts, tetradodecyl ammonium salts, and tridodecylbenzyl ammonium salts.
Claim 16
Independent Claim
31 words
A method according to any one of Claims 8 to 13, wherein the contacting is performed by dipping the substrate into the organic solvent containing the thermoplastic polyurethane and preformed complex.
Claim 17
Independent Claim
25 words
A method according to any one of Claims 8 to 13, wherein the solvent is removed by heating the contacted substrate to volatize the solvent.
Claim 18
Dependent Claim
26 words
A thermoplastic polyurethane product according to any one of Claims 1 to 7, in the form of a vascular catheter, wherein the substrate is a catheter.
Claim 19
Independent Claim
90 words
A method for preparing a slow release antithrombogenic/antibiotic thermoplastic polyurethane product, which comprises: contacting a preformed substrate with an organic solvent having dissolved therein (a) a thermoplastic polyurethane and b) a preformed complex of (i) a material chosen from an antithrombogenic material, an antibiotic material and mixtures thereof and (ii) a quaternary .ammonium compound, wherein contacting is performed for a time sufficient to form a thin film of the complex upon the substrate, and removing the solvent from the thermoplastic polyurethane layer to form the slow release thermoplastic polyurethane product.
Claim 20
Independent Claim
90 words
A method for preparing a slow release antithrombogenic/antibiotic thermoplastic polyurethane product, which comprises: contacting a preformed substrate with an organic solvent having dissolved therein (a) a thermoplastic polyurethane and b) a preformed complex of (i) a material chosen from an antithrombogenic material, an antibiotic material and mixtures thereof and (ii) a quaternary .ammonium compound, wherein contacting is performed for a time sufficient to form a thin film of the complex upon the substrate, and removing the solvent from the thermoplastic polyurethane layer to form the slow release thermoplastic polyurethane product.
Claim 21
Dependent Claim
20 words
A method according to Claim 2, wherein the antithrombogenic material is chosen from heparin, prostaglandins, sulphated polysaccharide, and mixtures thereof.
Claim 22
Dependent Claim
28 words
A method according to Claim 1, wherein the antibiotic material is chosen from penicillin, oxacillin, ticarcillin, carbenicillin, cephalosporins, cefoxitin, cefazolin, dicloxacillin, cloxacillin, and clavulanic acid, and mixtures thereof.
Claim 23
Dependent Claim
30 words
A method according to Claim 1, 2 or 3, wherein the substrate is substantially insoluble in the organic solvent used to dissolve the thermoplastic polyurethane and the antithrombogenic antibiotic material.
Claim 24
Dependent Claim
40 words
A method according to Claim 1, 2, 3 or 4, wherein the quaternary ammonium compound is a long chain alkyl quaternary ammonium salt having from 2 to 4 alkyl groups each alkyl group having from 10 to 30 carbon atoms.
Claim 25
Independent Claim
29 words
A method according to any one of Claims 1 to 5, wherein the quaternary ammonium compound is chosen from tridodecylmethyl ammonium salts, tetradodecyl ammonium salts, and tridodecylbenzyl ammonium salts.
Claim 26
Independent Claim
31 words
A method according to any one of Claims 1 to 6, wherein the contacting is performed by dipping the substrate into the organic solvent containing the thermoplastic polyurethane and preformed complex.
Claim 27
Independent Claim
25 words
A method according to any one of Claims 1 to 7 wherein the solvent is removed by heating the contacted substrate to volatize the solvent.
Claim 28
Independent Claim
21 words
A method according to any preceding claim, wherein a crosslinking agent is employed to render the polyurethane product thermosetting in nature.
Claim 29
Dependent Claim
27 words
10 A method according to any preceding claim, wherein the thermoplastic polyurethane product is in the form of a vascular catheter and the substrate is a catheter.
References Cited (Backward Citations)
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