Patent EP0249343A1 successfully refreshed from Google Patents.
EP0249343A1
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EP
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Moisture activation of transdermal drug delivery system
Assignee: Alza Corp
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Filing: 1987-05-14
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Granted: —
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Expires: 2007-05-14
Abstract
Abstract A diffusional drug delivery device is described which an provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continous administration over extended time periods.
Inventors
- 👤 Eun Soo Lee
- 👤 Patrick S.L. Wong
- 👤 Felix Theeuwes
- 👤 Su Il Yum
- 👤 Alejandro Zaffaroni
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 07:35
CPC Classifications
A; A61; A61M; A61M35/00; A61M35/003; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; A61K9/7038; A61K9/7046; A61K9/7069; A61K9/7092
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
132 words
In a controlled release medical device for delivering at least one agent to a biological environment, said device comprising an agent-containing reservoir having a surface through which said agent is released to said biological environment, the improvement whereby the onset of agent delivery at a therapeutically effective rate is delayed for a predetermined time after placement of said device in said biological environment, which improvement comprises: a delay means disposed between the biological environment and said reservoir, said delay means being substantially impermeable to said agent in a first state and permeable thereto in a second state; whereby the rate of release of said agent from said reservoir to said environment at said therapeutically effective rate is delayed until the delay means is converted from its first state to its second state.
Claim 2
Dependent Claim
132 words
In a controlled release medical device for delivering at least one agent to a biological environment, said device comprising an agent-containing reservoir having a surface through which said agent is released to said biological environment, the improvement whereby the onset of agent delivery at a therapeutically effective rate is delayed for a predetermined time after placement of said device in said biological environment, which improvement comprises: a delay means disposed between the biological environment and said reservoir, said delay means being substantially impermeable to said agent in a first state and permeable thereto in a second state; whereby the rate of release of said agent from said reservoir to said environment at said therapeutically effective rate is delayed until the delay means is converted from its first state to its second state.
Claim 3
Dependent Claim
15 words
The device of claim 1 wherein said delay means is substantially free of undissolved agent.
Claim 4
Dependent Claim
17 words
The device of claim 1 wherein said first state is dry and said second state is wet.
Claim 5
Dependent Claim
14 words
The device of claim 3 wherein said delay means is moistened by cutaneous liquids.
Claim 6
Independent Claim
76 words
The device as claimed in any preceding claim wherein said improvement further comprises: a second agent-containing reservoir having an agent releasing surface through which agent from said first and said second reservoirs is released to the biological environment, said delay means being disposed between the agent releasing surfaces of said first and said second reservoirs; whereby delivery of agent from said first reservoir will be delayed with respect to delivery of agent from said second reservoir.
Claim 7
Dependent Claim
79 words
The device of claim 5 wherein said improvement further comprises: a second delay means disposed between the biological environment and said second reservoir, said delay means being substantially impermeable to said agent in a first state and permeable thereto in a second state; whereby the rate of release of said agent from said second reservoir to said environment at said therapeutically effective rate is delayed until the delay means is converted from its first state to its second state.
Claim 8
Independent Claim
30 words
The device as claimed in any preceding claim wherein said first and/or second delay means is a polymer membrane selected from the group consisting of hydrophilic polymers and semihydrophilic polymers.
Claim 9
Dependent Claim
27 words
The device of claim 7 wherein said polymer membrane is selected from the group consisting of polyvinylalcohol, polyvinylpyrolidone, hydroxypropylmethyl cellulose, polyacrylamide, hydroxyethycellulose, hydroxymethylcellulose, polyacrylic acid and hydroxyethylmethyacrylate.
Claim 10
Independent Claim
35 words
The device as claimed in any preceding claim wherein said device further comprises: a rate controlling means for controlling the rate at which said delay means becomes hydrated when placed at its environment of use.
Claim 11
Dependent Claim
20 words
The device of claim 9 wherein a rate controlling means is disposed between said first and said second delay means.
Claim 12
Dependent Claim
21 words
The device of claim 9 wherein a rate controlling means is disposed between said second delay means and the biological environment.
Claim 13
Dependent Claim
20 words
The device of claim 10 wherein a delay means is disposed between said second delay means and the biological environment.
Claim 14
Independent Claim
17 words
The device of any preceding claim wherein said first and said second reservoirs contain the same agent.
Claim 15
Independent Claim
20 words
The device of anyone of claims 1 to 12 wherein said first reservoir and said second reservoir contain different agents.
Claim 16
Independent Claim
14 words
The device of any preceding claim wherein said agent is a nitrate, and/or nitroglycerin.
Claim 17
Independent Claim
17 words
The device as claimed in any preceding claim wherein said first reservoir contains a nitrate and/or nitroglycerin.
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