USRE30752E
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oxime carbonates
Assignee: Astellas Pharma Inc
•
Filing: 1979-02-21
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Granted: 1981-09-29
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Expires: 1999-02-21
Abstract
Abstract Novel carbonic acid esters are disclosed which are useful in a process for introducing esterified carboxy-type protective groups on amino and/or imino groups in amino and/or imino group-containing compounds for the temporary protection of said amino and/or imino groups. Additionally, processes for preparing said esters are also disclosed. .Iadd.
Inventors
- 👤 Masumi Itoh
- 👤 Takashi Kamiya
- 👤 Daijiro Hagiwara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:48
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
148 words
carbon atoms of lower alkyl for R' 1 is 4 or 5..]. .[.2. The compounds according claim 1 wherein Y' is cyano, nitro, carbamoyl, esterified carboxy, lower alkanoyl, aroyl, di-substituted carbamoyl, or aryl which may have substituents selected from the group consisting of lower alkoxy, nitro, cyano, and halo(lower)alkyl and Z' is aryl which may have substituents selected from the group consisting of lower alkoxy, nitro, cyano and halo(lower) alkyl..]. .[.3. The compounds according to claim 2, wherein R' 1 is lower alkyl which may have halogen, or ar(lower)alkyl which may have lower alkoxy, Y' is aryl or cyano and Z' is aryl; provided that when R' 1 is lower alkyl Y' is cyano and Z' is aryl, the number of carbon atoms of lower alkyl for R' 1 is 4 or 5..]. .[.4. The compounds according to claim 3, wherein R' 1 is lower alkyl which may
Claim 2
Dependent Claim
19 words
have halogen..]. 5. The compounds according to claim .[.4.]. .Iadd.30.Iaddend., wherein R' 1 is lower alkyl .Iadd.having four or
Claim 3
Dependent Claim
28 words
five carbon atoms.Iaddend.. 6. The compounds according to claim 5, wherein R' 1 is lower alkyl having 4 or 5 carbon atoms, Y' is cyano and Z' is
Claim 4
Dependent Claim
12 words
aryl. 7. The compounds according to claim 6, wherein R' 1 is
Claim 5
Dependent Claim
11 words
tert-butyl or 1-cyclopropylethyl and Z' is phenyl; or naphthyl. 8. The
Claim 6
Dependent Claim
12 words
compounds according to claim 7, wherein R' 1 is tert-butyl. 9. The
Claim 7
Dependent Claim
12 words
compound according to claim 8, wherein Z' is phenyl. 10. The compound
Claim 8
Dependent Claim
12 words
according to claim 8, wherein Z' is naphthyl. 11. The compound according
Claim 9
Dependent Claim
27 words
to claim 7, wherein R' 1 is 1-cyclopropylethyl and Z' is phenyl. 12. The compounds according to claim 5, wherein Y' is aryl and Z' is aryl.
Claim 10
Dependent Claim
12 words
The compound according to claim 12, wherein R' 1 is tert-butyl, Y'
Claim 11
Dependent Claim
33 words
is phenyl and Z' is phenyl. 14. The compounds according to claim .[.4.]. .Iadd.30.Iaddend., where R' 1 is lower alkyl having .[.halogen.]. .Iadd.at least one halogen substituent.Iaddend., Y' is cyano and Z' is
Claim 12
Dependent Claim
13 words
aryl. 15. The compounds according to claim 14, wherein R' 1 is ethyl
Claim 13
Dependent Claim
34 words
having chlorine and Z' is phenyl. 16. The compound according to claim 15, wherein R' 1 is 2,2,2-trichloroethyl. .[.17. The compounds according to claim 3, wherein R' 1 is ar(lower)alkyl which may have lower
Claim 14
Dependent Claim
23 words
alkoxy, Y' is cyano and Z' is aryl..]. 18. The compounds according to claim .[.17.]. .Iadd.29.Iaddend., wherein R' 1 is benzyl which may
Claim 15
Dependent Claim
20 words
have methoxy .Iadd.substituents .Iaddend.and Z' is phenyl. 19. The compounds according to claim 18, wherein R' 1 is benzyl or
Claim 16
Dependent Claim
11 words
4-methoxybenzyl. 20. The compound according to claim 19, wherein R' 1
Claim 17
Dependent Claim
13 words
is benzyl. 21. The compound according to claim 19, wherein R' 1 is
Claim 18
Dependent Claim
22 words
methoxybenzyl. 22. The compounds according to claim .[.1,.]. .Iadd.27 .Iaddend.wherein R' 1 is lower alkyl, Y' is cyano and Z' is aryl
Claim 19
Dependent Claim
23 words
having halogen. 23. The compounds according to claim 22, wherein R' 1 is tert-butyl and Z' is phenyl having .[.chlorine.]. .Iadd.at least one
Claim 20
Dependent Claim
161 words
chlorine substituent.Iaddend.. 24. The compound according to claim 23, wherein Z' is 4-chlorophenyl. .Iadd. 25. Carbonic acid esters of the formula: R'.sub.1 OCOOR'.sub.2 wherein R' 1 is lower alkyl which may have substituents selected from the group consisting of halogen, lower alkoxy and aryloxy, or ar(lower) alkyl, the aryl moiety of said ar(lower)alkyl may have substituents selected from the group consisting of lower alkoxy, halogen, nitro and cyano, R' 2 is a group represented by the formula: ##STR7##.Iaddend. wherein Y' is selected from the group consisting of cyano, nitro, carbamoyl, lower alkanoyl, or aryl, and said aryl may have substituents selected from the group consisting of halogen, lower alkoxy, nitro, cyano and halo (lower) alkyl, and Z' is aryl which may have substituents selected from the group consisting of halogen, lower alkoxy, nitro, cyano and halo (lower) alkyl; provided that when R' 1 is lower alkyl, Y' is aryl or cyano, and Z' is aryl, the number of carbon atoms of
Claim 21
Dependent Claim
214 words
lower alkyl for R' 1 is 4 or 5. .Iadd. 26. The compounds according to claim 25, wherein Y' is cyano, nitro, carbamoyl, lower alkanoyl, or aryl and said aryl may have substituents selected from the group consisting of lower alkoxy, nitro, cyano, and halo (lower) alkyl and Z' is aryl which may have substituents selected from the group consisting of lower alkoxy, nitro, cyano and halo (lower) alkyl. .Iaddend. .Iadd. 27. The compounds according to claim 25, wherein R' 1 is lower alkyl which may have halogen substituents, or ar(lower)alkyl, the aryl moiety of said ar(lower)alkyl may have lower alkoxy substituents Y' is cyano or aryl and Z' is aryl which may have halogen substituents; provided that when R' 1 is lower alkyl, Y' is aryl or cyano, and Z' is aryl, the number of carbon atoms of lower alkyl for R' 1 is 4 or 5. .Iaddend..Iadd. 28. The compounds according to claim 27, wherein Z' is aryl. .Iaddend..Iadd. 29. The compounds according to claim 28, wherein R' 1 is ar(lower) alkyl, the aryl moiety of which may have lower alkoxy substituents, Y' is cyano and Z' is aryl. .Iaddend..Iadd. 30. The compounds according to claim 28, wherein R' 1 is lower alkyl which may have one or more halogen substituents. .Iaddend.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-09-28 | 1985-03-30 | 1985-09-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-09-28 | 1989-03-30 | 1989-09-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-09-28 | 1993-03-30 | 1993-09-29 | $7700.00 | Window Closed / Lapsed |