Patent USRE30219E successfully refreshed from Google Patents.
USRE30219E
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US
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Method of preparing 8,8-disubstituted-6-methylergolines and related compounds
Assignee: Eli Lilly and Co
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Filing: 1979-02-05
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Granted: 1980-02-19
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Expires: 1999-02-05
Abstract
Abstract 8,8-Disubstituted-6-methylergolines and 9-ergolenes, are prepared by alkylation of lysergic, or isolysergic acid or their 9,10-dihydro analogues.
Inventors
- 👤 Nicholas J. Bach
- 👤 Edmund C. Kornfeld
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:05
CPC Classifications
C; C07; C07D; C07D457/00; C07D457/04; C07D457/02
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
133 words
The process which comprises reacting a (C 1 -C 3 ) alkyl dihydrolysergate of the formula ##STR5## with at least 2 moles of non-hydrolytic base of the class consisting of lithium tetramethylpiperidide and potassium diisopropyl amide in an inert solvent to form a 1,8-dianion of the said (C 1 -C 3 )alkyl dihydrolysergate, and then reacting said dianion with not more than one mole of an alkylating agent, R""(CH 2 ) n X wherein R"" is CH 3 , CH 2 , CN or ##STR6## X is halogen and n is 0, 1 or 2 to yield a (C 1 -C 3 )alkyl 8-R"" dihydrolysergate substantially free from any 1,8-di R"" dihydrolysergate and then isolating the thus formed (C 1 -C 3 )alkyl 8-R"" dihydrolysergate in substantially pure form from the reaction mixture.
Claim 2
Dependent Claim
133 words
The process which comprises reacting a (C 1 -C 3 ) alkyl dihydrolysergate of the formula ##STR5## with at least 2 moles of non-hydrolytic base of the class consisting of lithium tetramethylpiperidide and potassium diisopropyl amide in an inert solvent to form a 1,8-dianion of the said (C 1 -C 3 )alkyl dihydrolysergate, and then reacting said dianion with not more than one mole of an alkylating agent, R""(CH 2 ) n X wherein R"" is CH 3 , CH 2 , CN or ##STR6## X is halogen and n is 0, 1 or 2 to yield a (C 1 -C 3 )alkyl 8-R"" dihydrolysergate substantially free from any 1,8-di R"" dihydrolysergate and then isolating the thus formed (C 1 -C 3 )alkyl 8-R"" dihydrolysergate in substantially pure form from the reaction mixture.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-02-18 | 1983-08-20 | 1984-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-02-18 | 1987-08-20 | 1988-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-02-18 | 1991-08-20 | 1992-02-19 | $7700.00 | Window Closed / Lapsed |