US3968111A
Expired / Lapsed
US
⏱️ 0.0 years remaining
8,8-Disubstituted-6-methylergolines and related compounds
Assignee: Eli Lilly and Co
•
Filing: 1974-12-06
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Granted: 1976-07-06
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Expires: 1994-12-06
Abstract
Abstract 8,8-Disubstituted-6-methylergolines and 9-ergolenes, prepared by alkylation of lysergic, isolysergic or their 9,10-dihydro analogues, optionally followed by chemical modification of an 8-substituent.
Inventors
- 👤 Nicholas J. Bach
- 👤 Edmund C. Kornfeld
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:28
CPC Classifications
C; C07; C07D; C07D457/00; C07D457/04; A; A61; A61P; A61P25/00; A61P25/20; A61P35/00; C07D457/02
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
58 words
A compound of the formula ##SPC4## wherein R is alk, carbo(C 1 -C 3 )alkoxy, Cl or Br; R' is carboxyl, carbo(C 1 -C 3 )alkoxy, or CH 2 Z, wherein alk is (C 1 -C 3 ) alkyl and Z is H, OH, CN, OSO 2 alk, Y-phenyl or Y-alk; wherein Y is S or O; and
Claim 2
Dependent Claim
58 words
A compound of the formula ##SPC4## wherein R is alk, carbo(C 1 -C 3 )alkoxy, Cl or Br; R' is carboxyl, carbo(C 1 -C 3 )alkoxy, or CH 2 Z, wherein alk is (C 1 -C 3 ) alkyl and Z is H, OH, CN, OSO 2 alk, Y-phenyl or Y-alk; wherein Y is S or O; and
Claim 3
Dependent Claim
35 words
R" and R'" when taken singly are H; and, when taken together with the carbon atoms to which they are attached, form a double bond and pharmaceutically-acceptable acid addition salts thereof formed with non-toxic acids.
Claim 4
Dependent Claim
35 words
R" and R'" when taken singly are H; and, when taken together with the carbon atoms to which they are attached, form a double bond and pharmaceutically-acceptable acid addition salts thereof formed with non-toxic acids.
Claim 5
Dependent Claim
10 words
The compound according to claim 1, said compound being D-6-methyl-8α-cyanomethyl-8β-carbomethoxyergoline.
Claim 6
Dependent Claim
11 words
The compound according to claim 1, said compound being D-6, 8α-dimethyl-8β-mesyloxymethylergoline.
Claim 7
Dependent Claim
11 words
The compound according to claim 1, said compound being D-6, 8α-cyanomethyl-6,8β-dimethylergoline.
Claim 8
Dependent Claim
11 words
The compound according to claim 1, said compound being D-6, 8α-dimethyl-8β-cyanomethylergoline.
Claim 9
Dependent Claim
11 words
The compound according to claim 1, said compound being D-6, 8α-dimethyl-8β-carbomethoxyergoline.
Claim 10
Dependent Claim
11 words
The compound according to claim 1, said compound being D-6, 8α-dimethyl-8β-carbomethoxy-9-ergolene.
Claim 11
Dependent Claim
1 words
D-2,13-dibromo-6,8α-dimethyl-8β-carbomethoxyergoline.
Claim 12
Dependent Claim
1 words
D-2,13-dibromo-6,8α-dimethyl-8β-carbomethoxyergoline.
Claim 13
Dependent Claim
10 words
The compound according to claim 1, said compound being D-6,8,8-trimethylergoline.
References Cited (Backward Citations)
US3113133A
Cited
US2861074A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-06 | 1980-01-05 | 1980-07-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-06 | 1984-01-05 | 1984-07-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-06 | 1988-01-05 | 1988-07-06 | $7700.00 | Window Closed / Lapsed |