Patent US8396526B2 successfully refreshed from Google Patents.
US8396526B2
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US
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Method for spectrophotometric blood oxygenation monitoring
Assignee: BD Switzerland SARL
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Filing: 2006-05-10
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Granted: 2013-03-12
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Expires: 2026-05-10
Abstract
Abstract According to the present invention, a method and apparatus for non-invasively determining the blood oxygen saturation level within a subject's tissue is provided. The method comprises the steps of: 1) providing a near infrared spectrophotometric sensor operable to transmit light along a plurality of wavelengths into the subject's tissue; 2) sensing the light transmitted into the subject's tissue using the sensor, and producing signal data representative of the light sensed from the subject's tissue; 3) processing the signal data to account for physical characteristics of the subject; and 4) determining the blood oxygen saturation level within the subject's tissue using a difference in attenuation between the wavelengths. The apparatus includes a sensor having a light source and at least one light detector, which sensor is operably connected to a processor. The sensor is operable to transmit light along a plurality of wavelengths into the subject's tissue, and produce signal data representative of the light sensed from the subject's tissue. The algorithm is operable to process the signal data to account for the physical characteristics of the subject being sensed.
Inventors
- 👤 Paul Benni
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 20:30
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/14551; A61B5/14553; A61B5/02; A61B5/0205; A61B5/026; A61B5/0261; A61B5/14546; A61B5/14552; A61B5/1495; A61B5/68; A61B5/6801; A61B5/6813; A61B5/6814; G; G01; G01N; G01N21/00; G01N21/17; G01N21/25; G01N21/31; G01N21/35; G01N21/359; G01N21/47; G01N21/49; G01N21/314; G01N2021/3144
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
105 words
A method for non-invasively determining a blood oxygen saturation level of the microvasculature within a subject's tissue, comprising the steps of: providing a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light; detecting light after passage through the subject's tissue using the sensor, and producing initial signal data from the light sensed; calibrating the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed; and subsequent to calibrating the sensor, using the calibrated sensor to determine the blood oxygen saturation level within the subject's tissue.
Claim 2
Independent Claim
105 words
A method for non-invasively determining a blood oxygen saturation level of the microvasculature within a subject's tissue, comprising the steps of: providing a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light; detecting light after passage through the subject's tissue using the sensor, and producing initial signal data from the light sensed; calibrating the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed; and subsequent to calibrating the sensor, using the calibrated sensor to determine the blood oxygen saturation level within the subject's tissue.
Claim 3
Dependent Claim
24 words
The method of claim 1 , wherein the physical characteristics of the subject's tissue include pigmentation of skin and tissue disposed below the skin.
Claim 4
Dependent Claim
23 words
The method of claim 2 , wherein the processing calibrating step includes the use of absorption coefficients for pigmentation in the subject's tissue.
Claim 5
Dependent Claim
43 words
The method of claim 3 , wherein the calibrating step includes determining one or more calibration constants using the absorption coefficients for pigmentation, which calibration constants are used to within the step of determining the blood oxygen saturation level within the subject's tissue.
Claim 6
Independent Claim
116 words
A method for non-invasively determining a blood oxygen saturation level of the microcirculation within a subject's tissue using a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light, the method comprising the steps of: sensing the subject's tissue using the sensor, and producing initial signal data there from, which signal data is attributable to non-pulsatile blood flow within the microcirculation of the subject's tissue; calibrating the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed; and subsequent to calibrating the sensor, determining the blood oxygen saturation level within the subject's tissue using the calibrated sensor.
Claim 7
Independent Claim
116 words
A method for non-invasively determining a blood oxygen saturation level of the microcirculation within a subject's tissue using a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light, the method comprising the steps of: sensing the subject's tissue using the sensor, and producing initial signal data there from, which signal data is attributable to non-pulsatile blood flow within the microcirculation of the subject's tissue; calibrating the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed; and subsequent to calibrating the sensor, determining the blood oxygen saturation level within the subject's tissue using the calibrated sensor.
Claim 8
Dependent Claim
24 words
The method of claim 5 , wherein the physical characteristics of the subject's tissue comprise pigmentation of skin and tissue disposed below the skin.
Claim 9
Dependent Claim
22 words
The method of claim 6 , wherein the calibrating step includes the use of absorption coefficients for pigmentation in the subject's tissue.
Claim 10
Dependent Claim
30 words
The method of claim 5 , wherein the step of determining the blood oxygen saturation level within the subject's tissue comprises processing signal data other than the initial signal data.
Claim 11
Dependent Claim
37 words
The method of claim 8 , wherein the blood oxygen saturation level within the subject's tissue is determined using a difference in attenuation between a first of the wavelengths and each of the other of the wavelengths.
Claim 12
Independent Claim
124 words
A method for non-invasively determining a hemoglobin concentration level of the microcirculation within a subject's tissue, comprising the steps of: providing a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light; sensing the subject's tissue using the sensor, and producing initial signal data from the sensing, which initial signal data is attributable to non-pulsatile blood flow within the microcirculation of the subject's tissue; and calibrating the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed; and subsequent to calibrating the sensor, determining the concentration of at least one of oxyhemoglobin and deoxyhemoglobin of the microvasculature within the subject's tissue using the calibrated sensor.
Claim 13
Independent Claim
124 words
A method for non-invasively determining a hemoglobin concentration level of the microcirculation within a subject's tissue, comprising the steps of: providing a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light; sensing the subject's tissue using the sensor, and producing initial signal data from the sensing, which initial signal data is attributable to non-pulsatile blood flow within the microcirculation of the subject's tissue; and calibrating the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed; and subsequent to calibrating the sensor, determining the concentration of at least one of oxyhemoglobin and deoxyhemoglobin of the microvasculature within the subject's tissue using the calibrated sensor.
Claim 14
Dependent Claim
34 words
The method of claim 10 , further including the step of determining a blood oxygen saturation level within the subject's tissue using the determined concentrations of oxyhemoglobin and deoxyhemoglobin and the initial signal data.
Claim 15
Independent Claim
203 words
An apparatus for non-invasively determining a blood oxygen saturation level of the microcirculation within a subject's tissue, comprising: at least one spectrophotometric sensor having at least one light source and at least one light detector, wherein the light source is operable to transmit light along a plurality of wavelengths into the subject's tissue, and the light detector is operable to detect light from the light source after the light has traveled through the subject's tissue, and the sensor is operable to produce signal data attributable to non-pulsatile blood flow within the microcirculation of the subject's tissue from the detected light; and a processor operably connected to the at least one sensor, wherein the processor is adapted to sense the subject's tissue using the sensor, and produce initial signal data from the sensing, which initial signal data is attributable to non-pulsatile blood flow within the microcirculation of the subject's tissue, and to calibrate the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed, and subsequent to calibrating the sensor, determine the concentration of the blood oxygen saturation level of the microvasculature within the subject's tissue using the calibrated sensor.
Claim 16
Independent Claim
203 words
An apparatus for non-invasively determining a blood oxygen saturation level of the microcirculation within a subject's tissue, comprising: at least one spectrophotometric sensor having at least one light source and at least one light detector, wherein the light source is operable to transmit light along a plurality of wavelengths into the subject's tissue, and the light detector is operable to detect light from the light source after the light has traveled through the subject's tissue, and the sensor is operable to produce signal data attributable to non-pulsatile blood flow within the microcirculation of the subject's tissue from the detected light; and a processor operably connected to the at least one sensor, wherein the processor is adapted to sense the subject's tissue using the sensor, and produce initial signal data from the sensing, which initial signal data is attributable to non-pulsatile blood flow within the microcirculation of the subject's tissue, and to calibrate the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed, and subsequent to calibrating the sensor, determine the concentration of the blood oxygen saturation level of the microvasculature within the subject's tissue using the calibrated sensor.
Claim 17
Dependent Claim
16 words
The apparatus of claim 12 , wherein the physical characteristics of the subject's tissue comprise pigmentation.
Claim 18
Dependent Claim
18 words
The apparatus of claim 13 , wherein the algorithm utilizes absorption coefficients for pigmentation in the subject's tissue.
Claim 19
Dependent Claim
46 words
The apparatus of claim 14 , wherein the algorithm is operable to process the signal data to determine one or more calibration constants using the absorption coefficients for pigmentation, and operable to determine the blood oxygen saturation level within the subject's tissue using the calibration constants.
Claim 20
Dependent Claim
38 words
The apparatus of claim 15 , wherein the algorithm is operable to determine the blood oxygen saturation level within the subject's tissue using signal data other than that used to create to the one or more calibration constants.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2016-03-11 | 2016-09-10 | 2017-03-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2020-03-11 | 2020-09-10 | 2021-03-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2024-03-11 | 2024-09-10 | 2025-03-12 | $7700.00 | Window Closed / Lapsed |